| 2738 | Grin2b | glutamate ionotropic receptor NMDA type subunit 2B | ENCODES a protein that exhibits beta-catenin binding; cell adhesion molecule binding; D2 dopamine receptor binding; INVOLVED IN action potential; associative learning; auditory behavior; PARTICIPATES IN excitatory synaptic transmission pathway; long term potentiation; calcium/calmodulin dependent ki nase 2 signaling pathway; ASSOCIATED WITH alcohol use disorder; attention deficit hyperactivity disorder; Brain Hypoxia-Ischemia; FOUND IN apical dendrite; cell surface; cytoplasm; INTERACTS WITH (+)-pilocarpine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol | 4 | 170297811 | 170775420 | Rat | 698 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10687 | Grin2b | glutamate receptor, ionotropic, NMDA2B (epsilon 2) | Enables NMDA glutamate receptor activity and calcium channel activity. Involved in negative regulation of dendritic spine maintenance and regulation of synaptic plasticity. Acts upstream of or within several processes, including behavioral fear response; detection of mechanical stimulus involved in sensory perception of pain; and learning or memory. Located in several cellular components, including cytoplasmic vesicle; lysosome; and synaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including adipose tissue; central nervous system; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). [provided by Alliance of Genome Resources, Apr 2025] | 6 | 135690219 | 136150658 | Mouse | 767 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 731079 | GRIN2B | glutamate ionotropic receptor NMDA type subunit 2B | This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeab le component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017] | 12 | 13537337 | 13982134 | Human | 859 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8999814 | Grin2b | glutamate ionotropic receptor NMDA type subunit 2B | ENCODES a protein that exhibits beta-catenin binding (ortholog); calcium channel activity (ortholog); cell adhesion molecule binding (ortholog); INVOLVED IN action potential (ortholog); associative learning (ortholog); auditory behavior (ortholog); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; excitatory synaptic transmission pathway; long term potentiation; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); astigmatism (ortholog); FOUND IN apical dendrite (ortholog); cell surface (ortholog); ciliary tip (ortholog) | NW_004955413 | 10358931 | 10780004 | Chinchilla | 323 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11995063 | GRIN2B | glutamate ionotropic receptor NMDA type subunit 2B | ENCODES a protein that exhibits beta-catenin binding (ortholog); calcium channel activity (ortholog); cell adhesion molecule binding (ortholog); INVOLVED IN action potential (ortholog); associative learning (ortholog); auditory behavior (ortholog); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; excitatory synaptic transmission pathway; long term potentiation; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); astigmatism (ortholog); FOUND IN apical dendrite (ortholog); cell surface (ortholog); cytoplasm (ortholog) | 12 | 13543104 | 13987437 | Bonobo | 322 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12256628 | GRIN2B | glutamate ionotropic receptor NMDA type subunit 2B | ENCODES a protein that exhibits beta-catenin binding (ortholog); calcium channel activity (ortholog); cell adhesion molecule binding (ortholog); INVOLVED IN action potential (ortholog); associative learning (ortholog); auditory behavior (ortholog); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; excitatory synaptic transmission pathway; long term potentiation; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); astigmatism (ortholog); FOUND IN apical dendrite (ortholog); cell surface (ortholog); cytoplasm (ortholog) | 27 | 32470889 | 32883606 | Dog | 336 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12661197 | Grin2b | glutamate ionotropic receptor NMDA type subunit 2B | ENCODES a protein that exhibits beta-catenin binding (ortholog); calcium channel activity (ortholog); cell adhesion molecule binding (ortholog); INVOLVED IN action potential (ortholog); associative learning (ortholog); auditory behavior (ortholog); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; excitatory synaptic transmission pathway; long term potentiation; ASSOCIATED WITH alcohol use disorder (ortholog); astigmatism (ortholog); Ataxia (ortholog); FOUND IN apical dendrite (ortholog); cell surface (ortholog); cytoplasm (ortholog) | NW_004936587 | 3406055 | 3806956 | Squirrel | 326 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18903204 | Grin2b | glutamate ionotropic receptor NMDA type subunit 2B | ENCODES a protein that exhibits beta-catenin binding (ortholog); calcium channel activity (ortholog); cell adhesion molecule binding (ortholog); INVOLVED IN action potential (ortholog); associative learning (ortholog); auditory behavior (ortholog); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; excitatory synaptic transmission pathway; long term potentiation; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); astigmatism (ortholog); FOUND IN apical dendrite (ortholog); cell surface (ortholog); ciliary tip (ortholog) | | | | Naked Mole-Rat | 325 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625840181 | Grin2b | glutamate ionotropic receptor NMDA type subunit 2B | ENCODES a protein that exhibits beta-catenin binding (ortholog); calcium channel activity (ortholog); cell adhesion molecule binding (ortholog); INVOLVED IN action potential (ortholog); associative learning (ortholog); auditory behavior (ortholog); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; excitatory synaptic transmission pathway; long term potentiation; ASSOCIATED WITH alcohol use disorder (ortholog); astigmatism (ortholog); Ataxia (ortholog); FOUND IN apical dendrite (ortholog); cell surface (ortholog); ciliary tip (ortholog) | | | | Black Rat | 319 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14195993 | GRIN2B | glutamate ionotropic receptor NMDA type subunit 2B | ENCODES a protein that exhibits beta-catenin binding (ortholog); calcium channel activity (ortholog); cell adhesion molecule binding (ortholog); INVOLVED IN action potential (ortholog); associative learning (ortholog); auditory behavior (ortholog); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; excitatory synaptic transmission pathway; long term potentiation; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); astigmatism (ortholog); FOUND IN apical dendrite (ortholog); cell surface (ortholog); cytoplasm (ortholog) | | | | Pig | 326 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18607651 | GRIN2B | glutamate ionotropic receptor NMDA type subunit 2B | ENCODES a protein that exhibits beta-catenin binding (ortholog); calcium channel activity (ortholog); cell adhesion molecule binding (ortholog); INVOLVED IN action potential (ortholog); associative learning (ortholog); auditory behavior (ortholog); PARTICIPATES IN calcium/calmodulin dependent kinase 2 signaling pathway; excitatory synaptic transmission pathway; long term potentiation; ASSOCIATED WITH alcohol use disorder (ortholog); astigmatism (ortholog); Ataxia (ortholog); FOUND IN apical dendrite (ortholog); cell surface (ortholog); cytoplasm (ortholog) | | | | Green Monkey | 322 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240233 | grin2b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155240234 | grin2b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 14394517 | Grin2bem1Mcwi | glutamate ionotropic receptor NMDA type subunit 2B; CRISPR/Cas9 induced mutant 1, Mcwi | CRISPR/Cas9 system was used to introduce a mutation in the Grin2b gene of Crl:LE rat embryos. The resulting mutation is deletion of exon 3. | | | | Rat | | symbol , description | gene, allele |
| 16561012 | AC007527.1 | novel transcript, antisense to GRIN2B | | | | | Human | | name | gene, lncrna |
| 16572996 | AC007535.1 | novel transcript, antisense to GRIN2B | | 12 | 13582031 | 13620071 | Human | | name | gene, ncrna, MODEL [RefSeq] |
| 732718 | GRIN2D | glutamate ionotropic receptor NMDA type subunit 2D | N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010] | 19 | 48393668 | 48444931 | Human | 269 | description | gene, protein-coding, REVIEWED [RefSeq] |