| 2359 | Grem1 | gremlin 1, DAN family BMP antagonist | ENCODES a protein that exhibits BMP binding (ortholog); protein homodimerization activity (ortholog); protein sequestering activity (ortholog); INVOLVED IN negative regulation of cell growth; negative regulation of leukocyte chemotaxis; negative regulation of monocyte chemotaxis; PARTICIPATES IN Bon e morphogenetic proteins signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); familial adenomatous polyposis (ortholog); FOUND IN cell surface; extracellular space; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2,4-trimethylbenzene; 2-amino-2-deoxy-D-glucopyranose | 3 | 120966639 | 120978319 | Rat | 268 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 735959 | Grem1 | gremlin 1, DAN family BMP antagonist | Enables receptor ligand activity; transmembrane receptor protein tyrosine kinase activator activity; and vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including circulatory system development; nephron epithelium morphogenesis; and regulation of primar y metabolic process. Acts upstream of or within several processes, including embryonic limb morphogenesis; positive regulation of NF-kappaB transcription factor activity; and regulation of signal transduction. Located in extracellular space. Colocalizes with cell surface. Is expressed in several structures, including embryo mesenchyme; limb bud; neural ectoderm; sensory organ; and skeleton. Orthologous to human GREM1 (gremlin 1, DAN family BMP antagonist). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 113579020 | 113588993 | Mouse | 358 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1346462 | GREM1 | gremlin 1, DAN family BMP antagonist | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystin e knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] | 15 | 32718004 | 32745106 | Human | 318 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8879138 | Grem1 | gremlin 1, DAN family BMP antagonist | ENCODES a protein that exhibits BMP binding (ortholog); protein homodimerization activity (ortholog); protein sequestering activity (ortholog); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); cardiac muscle cell differentiation (ortholog); PARTICIPATES IN Bone morphogenet ic proteins signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); familial adenomatous polyposis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog) | NW_004955416 | 1812725 | 1825528 | Chinchilla | 82 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11955217 | GREM1 | gremlin 1, DAN family BMP antagonist | ENCODES a protein that exhibits BMP binding (ortholog); protein homodimerization activity (ortholog); protein sequestering activity (ortholog); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); cardiac muscle cell differentiation (ortholog); PARTICIPATES IN Bone morphogenet ic proteins signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); familial adenomatous polyposis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog) | 15 | 11213870 | 11230619 | Bonobo | 82 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12394086 | GREM1 | gremlin 1, DAN family BMP antagonist | ENCODES a protein that exhibits BMP binding (inferred); cytokine activity (inferred); protein homodimerization activity (inferred); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); cell-cell signaling (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathwa y; ASSOCIATED WITH colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); familial adenomatous polyposis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); INTERACTS WITH bisphenol A | 30 | 2219535 | 2231868 | Dog | 88 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12606991 | Grem1 | gremlin 1, DAN family BMP antagonist | ENCODES a protein that exhibits BMP binding (inferred); cytokine activity (inferred); protein homodimerization activity (inferred); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); cell-cell signaling (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathwa y; ASSOCIATED WITH colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); familial adenomatous polyposis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog) | NW_004936673 | 1394743 | 1399726 | Squirrel | 89 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243182 | grem1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18921821 | Grem1 | gremlin 1, DAN family BMP antagonist | ENCODES a protein that exhibits BMP binding (inferred); cytokine activity (inferred); protein homodimerization activity (inferred); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); cell-cell signaling (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathwa y; ASSOCIATED WITH colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); familial adenomatous polyposis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog) | | | | Naked Mole-Rat | 89 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20867511 | GREM1 | gremlin 1, DAN family BMP antagonist | ENCODES a protein that exhibits BMP binding (inferred); cytokine activity (inferred); protein homodimerization activity (inferred); INVOLVED IN animal organ morphogenesis (inferred); cardiac muscle cell differentiation (inferred); cardiac muscle cell myoblast differentiation (inferred); FOUND IN cel l surface (inferred); extracellular region (inferred); extracellular space (inferred) | | | | Green Monkey | 52 | symbol | gene, protein-coding |
| 18606793 | GREM1 | gremlin 1, DAN family BMP antagonist | ENCODES a protein that exhibits BMP binding (ortholog); protein homodimerization activity (ortholog); protein sequestering activity (ortholog); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); cardiac muscle cell differentiation (ortholog); PARTICIPATES IN Bone morphogenet ic proteins signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); familial adenomatous polyposis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog) | | | | Green Monkey | 82 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 150657903 | GREM1 | gremlin 1, DAN family BMP antagonist | | | | | Dog | | symbol | gene, protein-coding |
| 14190206 | GREM1 | gremlin 1, DAN family BMP antagonist | ENCODES a protein that exhibits BMP binding (inferred); cytokine activity (inferred); protein homodimerization activity (inferred); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); cell-cell signaling (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathwa y; ASSOCIATED WITH colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); familial adenomatous polyposis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog); INTERACTS WITH deoxynivalenol; graphene oxide | | | | Pig | 91 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625988227 | Grem1 | gremlin 1, DAN family BMP antagonist | ENCODES a protein that exhibits BMP binding (ortholog); protein homodimerization activity (ortholog); protein sequestering activity (ortholog); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); cardiac muscle cell differentiation (ortholog); PARTICIPATES IN Bone morphogenet ic proteins signaling pathway; ASSOCIATED WITH colorectal cancer (ortholog); Colorectal Neoplasms (ortholog); familial adenomatous polyposis (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog) | | | | Black Rat | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256518 | grem1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 16562374 | GREM1-AS1 | GREM1 antisense RNA 1 | | 15 | 32718101 | 32718865 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |