Grem1 (gremlin 1, DAN family BMP antagonist) - Rat Genome Database

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Gene: Grem1 (gremlin 1, DAN family BMP antagonist) Ictidomys tridecemlineatus
Analyze
Symbol: Grem1
Name: gremlin 1, DAN family BMP antagonist
RGD ID: 12606991
Description: ENCODES a protein that exhibits BMP binding (ortholog); protein homodimerization activity (ortholog); receptor ligand activity (ortholog); INVOLVED IN angiogenesis (ortholog); animal organ morphogenesis (ortholog); apoptotic process (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colon cancer (ortholog); Colorectal Neoplasms (ortholog); FOUND IN cell surface (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: gremlin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864080,752,116 - 80,764,323 (-)NCBI
SpeTri2.0NW_0049366731,394,743 - 1,399,726 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
animal organ morphogenesis  (ISO)
apoptotic process  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cell morphogenesis  (ISO)
cell-cell signaling  (ISO)
collagen fibril organization  (ISO)
determination of dorsal identity  (ISO)
embryonic limb morphogenesis  (ISO)
endothelial cell migration  (ISO)
limb development  (ISO)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of bone mineralization  (ISO)
negative regulation of bone mineralization involved in bone maturation  (ISO)
negative regulation of bone remodeling  (ISO)
negative regulation of bone trabecula formation  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of chondrocyte differentiation  (ISO)
negative regulation of leukocyte chemotaxis  (ISO)
negative regulation of monocyte chemotaxis  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of osteoclast proliferation  (ISO)
negative regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of peptidyl-tyrosine autophosphorylation  (ISO)
positive regulation of protein tyrosine kinase activity  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of signaling receptor activity  (ISO)
positive regulation of telomerase activity  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
proximal/distal pattern formation  (ISO)
regulation of epithelial to mesenchymal transition  (ISO)
regulation of focal adhesion assembly  (ISO)
regulation of stress-activated MAPK cascade  (ISO)
signal transduction  (ISO)
signal transduction by p53 class mediator  (ISO)
ureteric bud formation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Grem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864080,752,116 - 80,764,323 (-)NCBI
SpeTri2.0NW_0049366731,394,743 - 1,399,726 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GREM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1532,718,004 - 32,745,106 (+)EnsemblGRCh38hg38GRCh38
GRCh381532,718,004 - 32,745,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371533,010,205 - 33,037,307 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361530,797,497 - 30,814,158 (+)NCBINCBI36hg18NCBI36
Build 341530,797,593 - 30,814,158NCBI
Celera159,812,058 - 9,828,720 (+)NCBI
Cytogenetic Map15q13.3NCBI
HuRef159,872,067 - 9,888,724 (+)NCBIHuRef
CHM1_11533,128,259 - 33,144,912 (+)NCBICHM1_1
Grem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392113,579,020 - 113,588,993 (-)NCBIGRCm39mm39
GRCm39 Ensembl2113,576,509 - 113,588,991 (-)Ensembl
GRCm382113,748,675 - 113,758,648 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2113,746,164 - 113,758,646 (-)EnsemblGRCm38mm10GRCm38
MGSCv372113,588,832 - 113,598,805 (-)NCBIGRCm37mm9NCBIm37
MGSCv362113,549,514 - 113,559,485 (-)NCBImm8
Celera2114,881,929 - 114,891,879 (-)NCBICelera
Cytogenetic Map2E4NCBI
cM Map257.43NCBI
Grem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23100,512,317 - 100,524,001 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl3105,203,309 - 105,214,989 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03105,203,309 - 105,214,989 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03111,779,965 - 111,791,645 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4399,597,201 - 99,608,935 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1399,493,630 - 99,505,363 (-)NCBI
Celera399,483,712 - 99,495,442 (-)NCBICelera
Cytogenetic Map3q35NCBI
Grem1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554161,812,676 - 1,826,271 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554161,812,725 - 1,825,528 (-)NCBIChiLan1.0ChiLan1.0
GREM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11530,051,483 - 30,068,243 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01511,213,870 - 11,230,619 (+)NCBIMhudiblu_PPA_v0panPan3
GREM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1302,219,535 - 2,231,868 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl302,222,898 - 2,225,418 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha302,269,149 - 2,281,447 (-)NCBI
ROS_Cfam_1.0302,332,148 - 2,344,441 (-)NCBI
UMICH_Zoey_3.1302,268,479 - 2,281,286 (-)NCBI
UNSW_CanFamBas_1.0302,367,729 - 2,380,025 (-)NCBI
UU_Cfam_GSD_1.0302,496,103 - 2,508,404 (-)NCBI
GREM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1136,617,069 - 136,629,292 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11136,617,041 - 136,629,293 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21152,742,118 - 152,749,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GREM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12650,152,097 - 50,169,760 (-)NCBI
Vero_WHO_p1.0NW_02366604890,715,793 - 90,733,042 (+)NCBI
Grem1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248041,606,182 - 1,620,932 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005337135   ⟹   XP_005337192
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864080,752,116 - 80,764,323 (-)NCBI
SpeTri2.0NW_0049366731,394,743 - 1,399,726 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040275475   ⟹   XP_040131409
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864080,752,116 - 80,764,323 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005337192 (Get FASTA)   NCBI Sequence Viewer  
  XP_040131409 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3261567 (Get FASTA)   NCBI Sequence Viewer  
  KAG3261568 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005337192   ⟸   XM_005337135
- UniProtKB: I3NCG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040131409   ⟸   XM_040275475
Protein Domains
CTCK


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000010068 ENTREZGENE
Ensembl Protein ENSSTOP00000022065 ENTREZGENE
NCBI Gene Grem1 ENTREZGENE
UniProt I3NCG8 ENTREZGENE