| 2720 | Gnrh1 | gonadotropin releasing hormone 1 | ENCODES a protein that exhibits gonadotropin hormone-releasing hormone activity; INVOLVED IN estrous cycle; female pregnancy; male sex determination; PARTICIPATES IN gonadotropin-releasing hormone signaling pathway; ASSOCIATED WITH prostatic hypertrophy; Adrenal Gland Neoplasms (ortholog); adult res piratory distress syndrome (ortholog); FOUND IN axon terminus; cytoplasmic side of rough endoplasmic reticulum membrane; dendrite; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol; 17beta-estradiol 3-benzoate | 15 | 46147878 | 46152086 | Rat | 253 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 69083 | GNRH1 | gonadotropin releasing hormone 1 | This gene encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the gonadotropin-releasing hormone (GnRH) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gon adoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in this gene are associated with hypogonadotropic hypogonadism. [provided by RefSeq, Nov 2015] | 8 | 25419258 | 25425040 | Human | 335 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553302 | Gnrh1 | gonadotropin releasing hormone 1 | This gene encodes hypophysiotropic peptides belonging to the family of gonadotropin-releasing hormones that stimulate the release of gonadotropins and suppress secretion of prolactin from the pituitary gland. The encoded protein is proteolytically processed to generate two biologically active mature peptides. A deletional mutation encompassing the distal half of this gene in mice resulting in the loss of the encoded protein leads to hypogonadism and infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] | 14 | 67982717 | 67986889 | Mouse | 339 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8931290 | Gnrh1 | gonadotropin releasing hormone 1 | ENCODES a protein that exhibits gonadotropin hormone-releasing hormone activity (ortholog); INVOLVED IN estrous cycle (ortholog); female pregnancy (ortholog); male sex determination (ortholog); ASSOCIATED WITH Adrenal Gland Neoplasms (ortholog); adult respiratory distress syndrome (ortholog); amenor rhea (ortholog); FOUND IN axon terminus (ortholog); cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); dendrite (ortholog) | NW_004955403 | 48341731 | 48346595 | Chinchilla | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11765321 | GNRH1 | gonadotropin releasing hormone 1 | ENCODES a protein that exhibits gonadotropin hormone-releasing hormone activity (ortholog); INVOLVED IN estrous cycle (ortholog); female pregnancy (ortholog); male sex determination (ortholog); ASSOCIATED WITH Adrenal Gland Neoplasms (ortholog); adult respiratory distress syndrome (ortholog); amenor rhea (ortholog); FOUND IN axon terminus (ortholog); cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); dendrite (ortholog) | 8 | 24700268 | 24707332 | Bonobo | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12318630 | GNRH1 | gonadotropin releasing hormone 1 | ENCODES a protein that exhibits gonadotropin hormone-releasing hormone activity (ortholog); INVOLVED IN estrous cycle (ortholog); female pregnancy (ortholog); male sex determination (ortholog); ASSOCIATED WITH Adrenal Gland Neoplasms (ortholog); adult respiratory distress syndrome (ortholog); amenor rhea (ortholog); FOUND IN axon terminus (ortholog); cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); dendrite (ortholog) | 25 | 32038631 | 32043192 | Dog | 61 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12665069 | Gnrh1 | gonadotropin releasing hormone 1 | ENCODES a protein that exhibits gonadotropin hormone-releasing hormone activity (ortholog); INVOLVED IN estrous cycle (ortholog); female pregnancy (ortholog); male sex determination (ortholog); ASSOCIATED WITH Adrenal Gland Neoplasms (ortholog); adult respiratory distress syndrome (ortholog); amenor rhea (ortholog); FOUND IN axon terminus (ortholog); cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); dendrite (ortholog) | NW_004936757 | 1282185 | 1285804 | Squirrel | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18546394 | GNRH1 | gonadotropin releasing hormone 1 | ENCODES a protein that exhibits gonadotropin hormone-releasing hormone activity (ortholog); INVOLVED IN estrous cycle (ortholog); female pregnancy (ortholog); male sex determination (ortholog); ASSOCIATED WITH Adrenal Gland Neoplasms (ortholog); adult respiratory distress syndrome (ortholog); amenor rhea (ortholog); FOUND IN axon terminus (ortholog); cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); dendrite (ortholog) | | | | Green Monkey | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13976848 | GNRH1 | gonadotropin releasing hormone 1 | ENCODES a protein that exhibits gonadotropin hormone-releasing hormone activity (ortholog); INVOLVED IN estrous cycle (ortholog); female pregnancy (ortholog); male sex determination (ortholog); ASSOCIATED WITH Adrenal Gland Neoplasms (ortholog); adult respiratory distress syndrome (ortholog); amenor rhea (ortholog); FOUND IN axon terminus (ortholog); cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); dendrite (ortholog); INTERACTS WITH 3',5'-cyclic AMP; cobalt atom; copper atom | | | | Pig | 72 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18935427 | Gnrh1 | gonadotropin releasing hormone 1 | ENCODES a protein that exhibits gonadotropin hormone-releasing hormone activity (ortholog); INVOLVED IN estrous cycle (ortholog); female pregnancy (ortholog); male sex determination (ortholog); ASSOCIATED WITH Adrenal Gland Neoplasms (ortholog); adult respiratory distress syndrome (ortholog); amenor rhea (ortholog); FOUND IN axon terminus (ortholog); cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); dendrite (ortholog) | | | | Naked Mole-Rat | 60 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155254883 | gnrh1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626123643 | Gnrh1 | gonadotropin releasing hormone 1 | ENCODES a protein that exhibits gonadotropin hormone-releasing hormone activity (ortholog); INVOLVED IN estrous cycle (ortholog); female pregnancy (ortholog); male sex determination (ortholog); ASSOCIATED WITH Adrenal Gland Neoplasms (ortholog); adult respiratory distress syndrome (ortholog); amenor rhea (ortholog); FOUND IN axon terminus (ortholog); cytoplasmic side of rough endoplasmic reticulum membrane (ortholog); dendrite (ortholog) | | | | Black Rat | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155238679 | gnrh1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 1347634 | GNRH2 | gonadotropin releasing hormone 2 | This gene is a member of the gonadotropin-releasing hormone (GnRH) gene family. Proteins encoded by members of this gene family are proteolytically cleaved to form neuropeptides which, in part, regulate reproductive functions by stimulating the production and release of the gonadotropins follicle-st imulating hormone (FSH) and luteinizing hormone (LH). The human GNRH2 gene is predicted to encode a preproprotein from which a mature neuropeptide of 10 amino acids is cleaved. However, while the human genome retains the sequence for a functional GNRH2 decapeptide, translation of the human GNRH2 gene has not yet been demonstrated and the GNRH2 gene of chimpanzees, gorilla, and Sumatran orangutan have a premature stop at codon eight of the decapeptide sequence which suggests GNRH2 was a pseudogene in the hominid lineage. The GNRH2 gene is also believed to be a pseudogene in many other mammalian species such as mouse and cow. The receptor for this gene (GNRHR2) is predicted to be a pseudogene in human as well as many other mammalian species. The closely related GNRH1 and GNRHR1 genes are functional in human and other mammals and are generally functional in vertebrates. [provided by RefSeq, Mar 2019] | 20 | 3043622 | 3045747 | Human | 29 | description | gene, protein-coding, REVIEWED [RefSeq] |