| 2676 | Gdi1 | GDP dissociation inhibitor 1 | ENCODES a protein that exhibits Rab GDP-dissociation inhibitor activity; small GTPase binding; GDP-dissociation inhibitor activity (ortholog); INVOLVED IN negative regulation of axonogenesis; positive regulation of axon extension; response to calcium ion; ASSOCIATED WITH amyotrophic lateral sclerosi s type 1 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cognitive disorder (ortholog); FOUND IN axon; myelin sheath; neuronal cell body; INTERACTS WITH 17alpha-ethynylestradiol; 2,4-dibromophenyl 2,4,5-tribromophenyl ether; 6-propyl-2-thiouracil | X | 157238900 | 157245562 | Rat | 138 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10630 | Gdi1 | GDP dissociation inhibitor 1 | Predicted to enable Rab GDP-dissociation inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rab protein signal transduction; negative regulation of protein targeting to membrane; and regulation of axonogenesis. Located in myelin sheath. Is expressed in several structures, including liver; nervous system; placenta; sensory organ; and spleen. Used to study non-syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability; non-syndromic X-linked intellectual disability 41; and psychotic disorder. Orthologous to human GDI1 (GDP dissociation inhibitor 1). [provided by Alliance of Genome Resources, Apr 2025] | X | 73348618 | 73355473 | Mouse | 178 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 731728 | GDI1 | GDP dissociation inhibitor 1 | GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from ra b proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008] | X | 154437154 | 154443467 | Human | 163 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8768195 | Gdi1 | GDP dissociation inhibitor 1 | ENCODES a protein that exhibits GDP-dissociation inhibitor activity (ortholog); Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of axonogenesis (ortholog); negative regulation of protein targeting to membrane (ortholog); positive r egulation of axon extension (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cognitive disorder (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog) | NW_004955580 | 935021 | 941081 | Chinchilla | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11719602 | GDI1 | GDP dissociation inhibitor 1 | ENCODES a protein that exhibits Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of axonogenesis (ortholog); positive regulation of axon extension (ortholog); response to calcium ion (ortholog); ASSOCIATED WITH amyotrophic lateral s clerosis type 1 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cognitive disorder (ortholog); FOUND IN axon (ortholog); myelin sheath (ortholog); neuronal cell body (ortholog) | X | 143878690 | 143885251 | Bonobo | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12290491 | GDI1 | GDP dissociation inhibitor 1 | ENCODES a protein that exhibits Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of axonogenesis (ortholog); negative regulation of protein targeting to membrane (ortholog); positive regulation of axon extension (ortholog); ASSOCIAT ED WITH amyotrophic lateral sclerosis type 1 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cognitive disorder (ortholog); FOUND IN axon (ortholog); myelin sheath (ortholog); neuronal cell body (ortholog); INTERACTS WITH clofibrate | X | 122141633 | 122146724 | Dog | 55 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12493861 | Gdi1 | GDP dissociation inhibitor 1 | ENCODES a protein that exhibits Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of axonogenesis (ortholog); positive regulation of axon extension (ortholog); response to calcium ion (ortholog); ASSOCIATED WITH amyotrophic lateral s clerosis type 1 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cognitive disorder (ortholog); FOUND IN axon (ortholog); myelin sheath (ortholog); neuronal cell body (ortholog) | NW_004936809 | 1188793 | 1194816 | Squirrel | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18600686 | GDI1 | GDP dissociation inhibitor 1 | ENCODES a protein that exhibits Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of axonogenesis (ortholog); positive regulation of axon extension (ortholog); response to calcium ion (ortholog); ASSOCIATED WITH amyotrophic lateral s clerosis type 1 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cognitive disorder (ortholog); FOUND IN axon (ortholog); myelin sheath (ortholog); neuronal cell body (ortholog) | | | | Green Monkey | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626071468 | Gdi1 | GDP dissociation inhibitor 1 | ENCODES a protein that exhibits GDP-dissociation inhibitor activity (ortholog); Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of axonogenesis (ortholog); negative regulation of protein targeting to membrane (ortholog); positive r egulation of axon extension (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cognitive disorder (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13934068 | GDI1 | GDP dissociation inhibitor 1 | ENCODES a protein that exhibits Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of axonogenesis (ortholog); positive regulation of axon extension (ortholog); response to calcium ion (ortholog); ASSOCIATED WITH amyotrophic lateral s clerosis type 1 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cognitive disorder (ortholog); FOUND IN axon (ortholog); myelin sheath (ortholog); neuronal cell body (ortholog) | | | | Pig | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284907547 | gdi1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18928884 | Gdi1 | GDP dissociation inhibitor 1 | ENCODES a protein that exhibits Rab GDP-dissociation inhibitor activity (ortholog); small GTPase binding (ortholog); INVOLVED IN negative regulation of axonogenesis (ortholog); positive regulation of axon extension (ortholog); response to calcium ion (ortholog); ASSOCIATED WITH amyotrophic lateral s clerosis type 1 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); cognitive disorder (ortholog); FOUND IN axon (ortholog); myelin sheath (ortholog); neuronal cell body (ortholog) | | | | Naked Mole-Rat | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14376783 | GDI1 | | | | | | Yeast | | symbol | gene, null |
| 284906999 | gdi1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 288083349 | gdi1.S | | | | | | African Clawed Frog | | symbol | gene, null |