| 2597 | Fcer1a | Fc epsilon receptor Ia | ENCODES a protein that exhibits high-affinity IgE receptor activity (ortholog); IgE binding (ortholog); IgE receptor activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); eosinophil degranulation (ortholog); leukotriene biosynthetic process (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; asthma pathway; ASSOCIATED WITH asthma (ortholog); drug allergy (ortholog); Drug Eruptions (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; ammonium chloride | 13 | 88218427 | 88224723 | Rat | 91 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10570 | Fcer1a | Fc receptor, IgE, high affinity I, alpha polypeptide | Enables IgE binding activity and IgE receptor activity. Acts upstream of or within several processes, including leukotriene biosynthetic process; positive regulation of immune effector process; and positive regulation of macromolecule metabolic process. Located in external side of plasma membrane. O rthologous to human FCER1A (Fc epsilon receptor Ia). [provided by Alliance of Genome Resources, Jul 2025] | 1 | 173048836 | 173054799 | Mouse | 107 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736318 | FCER1A | Fc epsilon receptor Ia | The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is compri sed of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011] | 1 | 159283575 | 159308202 | Human | 88 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8880409 | Fcer1a | Fc fragment of IgE receptor Ia | ENCODES a protein that exhibits high-affinity IgE receptor activity (ortholog); IgE binding (ortholog); IgE receptor activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); eosinophil degranulation (ortholog); leukotriene biosynthetic process (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH asthma (ortholog); drug allergy (ortholog); Drug Eruptions (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog) | NW_004955468 | 11094792 | 11101191 | Chinchilla | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11772038 | FCER1A | Fc epsilon receptor Ia | ENCODES a protein that exhibits IgE receptor activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); leukotriene biosynthetic process (ortholog); positive regulation of calcium-mediated signaling (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH asthma (ortholog); drug allergy (ortholog); Drug Eruptions (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); plasma membrane (inferred) | 1 | 134655230 | 134660961 | Bonobo | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12217247 | FCER1A | Fc epsilon receptor Ia | ENCODES a protein that exhibits IgE receptor activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); eosinophil degranulation (ortholog); leukotriene biosynthetic process (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH asthma ( ortholog); drug allergy (ortholog); Drug Eruptions (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog) | 38 | 22683478 | 22688842 | Dog | 40 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12616261 | Fcer1a | Fc fragment of IgE receptor Ia | ENCODES a protein that exhibits high-affinity IgE receptor activity (ortholog); IgE binding (ortholog); IgE receptor activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); eosinophil degranulation (ortholog); leukotriene biosynthetic process (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH asthma (ortholog); drug allergy (ortholog); Drug Eruptions (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog) | NW_004936740 | 1201370 | 1206871 | Squirrel | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934481 | Fcer1a | Fc fragment of IgE receptor Ia | ENCODES a protein that exhibits high-affinity IgE receptor activity (ortholog); IgE binding (ortholog); IgE receptor activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); eosinophil degranulation (ortholog); leukotriene biosynthetic process (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH asthma (ortholog); drug allergy (ortholog); Drug Eruptions (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog) | | | | Naked Mole-Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625926131 | Fcer1a | Fc fragment of IgE receptor Ia | ENCODES a protein that exhibits high-affinity IgE receptor activity (ortholog); IgE binding (ortholog); IgE receptor activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); eosinophil degranulation (ortholog); leukotriene biosynthetic process (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH asthma (ortholog); drug allergy (ortholog); Drug Eruptions (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog) | | | | Black Rat | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14017212 | FCER1A | Fc epsilon receptor Ia | ENCODES a protein that exhibits IgE receptor activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); leukotriene biosynthetic process (ortholog); positive regulation of calcium-mediated signaling (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH asthma (ortholog); drug allergy (ortholog); Drug Eruptions (ortholog); FOUND IN external side of plasma membrane (ortholog); INTERACTS WITH resveratrol | | | | Pig | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18728454 | FCER1A | Fc epsilon receptor Ia | ENCODES a protein that exhibits IgE receptor activity (ortholog); INVOLVED IN cell surface receptor signaling pathway (ortholog); leukotriene biosynthetic process (ortholog); positive regulation of calcium-mediated signaling (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; ASSOCIATED WITH asthma (ortholog); drug allergy (ortholog); Drug Eruptions (ortholog); FOUND IN cell surface (inferred); external side of plasma membrane (inferred); extracellular region (inferred) | | | | Green Monkey | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1605010 | CLNK | cytokine dependent hematopoietic cell linker | MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A CER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008] | 4 | 10486395 | 10734846 | Human | 43 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 1314505 | MNDA | myeloid cell nuclear differentiation antigen | The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-20 2, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008] | 1 | 158831351 | 158849502 | Human | 116 | description | gene, protein-coding, REVIEWED [RefSeq] |