| 2545 | Egr3 | early growth response 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN cell migration involved in sprouting angiogenesis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to vascular endothelial growth factor stimulus (ortholog); ASSOCIATED WITH Ataxia (ortholog); COVID-19 (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); synapse (inferred); INTERACTS WITH (+)-pilocarpine; 2,3,7,8-Tetrachlorodibenzofuran; 2-methoxyethanol | 15 | 51560482 | 51565778 | Rat | 228 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 736598 | EGR3 | early growth response 3 | This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in control ing biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010] | 8 | 22687659 | 22693480 | Human | 225 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736599 | Egr3 | early growth response 3 | Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within neuromuscular synaptic transmission; peripheral nervous system development; a nd regulation of T cell differentiation. Predicted to be located in nucleoplasm. Is expressed in several structures, including ganglionic eminence; genitourinary system; limb musculature; tooth; and vibrissa. Orthologous to human EGR3 (early growth response 3). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 70314766 | 70320062 | Mouse | 257 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8825814 | Egr3 | early growth response 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN cell migration involved in sprouting angiogenesis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to vascular endothelial growth factor stimulus (ortholog); ASSOCIATED WITH Ataxia (ortholog); COVID-19 (ortholog) | NW_004955403 | 46105447 | 46108149 | Chinchilla | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11768049 | EGR3 | early growth response 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN neuromuscular synaptic transmission (ortholog); peripheral nervous system development (orthol og); positive regulation of T cell differentiation in thymus (ortholog); ASSOCIATED WITH Ataxia (ortholog); COVID-19 (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 8 | 21937516 | 21943646 | Bonobo | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12192188 | EGR3 | early growth response 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN neuromuscular synaptic transmission (ortholog); peripheral nervous system development (orthol og); positive regulation of T cell differentiation in thymus (ortholog); ASSOCIATED WITH Ataxia (ortholog); COVID-19 (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | 25 | 34591691 | 34597144 | Dog | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12470462 | Egr3 | early growth response 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN actin cortical patch localization (inferred); cell division (inferred); cell migration involv ed in sprouting angiogenesis (inferred); ASSOCIATED WITH Ataxia (ortholog); COVID-19 (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); cytoskeleton (inferred) | NW_004936555 | 6347446 | 6393784 | Squirrel | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155237869 | egr3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14078794 | EGR3 | early growth response 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN neuromuscular synaptic transmission (ortholog); peripheral nervous system development (orthol og); positive regulation of T cell differentiation in thymus (ortholog); ASSOCIATED WITH Ataxia (ortholog); COVID-19 (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18919158 | Egr3 | early growth response 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN cell migration involved in sprouting angiogenesis (ortholog); cellular response to fibroblast growth factor stimu lus (ortholog); cellular response to vascular endothelial growth factor stimulus (ortholog); ASSOCIATED WITH Ataxia (ortholog); COVID-19 (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Naked Mole-Rat | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626097119 | Egr3 | early growth response 3 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); sequence-specific DNA binding (ortholog); sequence-specific double-stranded DNA binding (ortholog); INVOLVED IN cell migration involved in sprouting angiogenesis (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to vascular endothelial growth factor stimulus (ortholog); ASSOCIATED WITH Ataxia (ortholog); COVID-19 (ortholog) | | | | Black Rat | 16 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18440817 | EGR3 | early growth response 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN neuromuscular synaptic transmission (ortholog); peripheral nervous system development (orthol og); positive regulation of T cell differentiation in thymus (ortholog); ASSOCIATED WITH Ataxia (ortholog); COVID-19 (ortholog); FOUND IN nucleoplasm (inferred); nucleus (inferred) | | | | Green Monkey | 28 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245333 | egr3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251082 | egr3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 597538546 | EGR3-AS1 | EGR3 and PEBP4 antisense RNA 1 | | | | | Human | | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna |
| 16563056 | AC105046.1 | novel transcript, overlapping to EGR3 | | | | | Human | | name | gene, lncrna |
