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Gene: Egr3 (early growth response 3) Ictidomys tridecemlineatus

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Symbol:

Egr3

Name:

early growth response 3

RGD ID:

12470462

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN actin cortical patch localization (inferred); cell migration involved in sprouting angiogenesis (inferred); cellular response to fibroblast growth factor stimulus (inferred); ASSOCIATED WITH Ataxia (ortholog); Conotruncal Cardiac Defects (ortholog); COVID-19 (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); cytoskeleton (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Bin3; bridging integrator 3; bridging integrator 3, transcript variant X1; bridging integrator 3, transcript variant X4; early growth response 3, transcript variant X1; early growth response 3, transcript variant X2; early growth response 3, transcript variant X3; early growth response protein 3

RGD Orthologs

Alliance Orthologs

More Info

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More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EGR3 (early growth response 3)	NCBI	Ortholog
Mus musculus (house mouse):	Bin3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Bin3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bin3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BIN3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BIN3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BIN3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	BIN3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bin3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	12,155,031 - 12,223,380 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936555	6,410,279 - 6,415,482 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0 Ensembl	NW_004936555	6,356,691 - 6,393,825 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936555	6,347,446 - 6,393,784 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Ataxia (ISO)

Conotruncal Cardiac Defects (ISO)

COVID-19 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cortical patch localization (IEA)

cell migration involved in sprouting angiogenesis (IEA)

cellular response to fibroblast growth factor stimulus (IEA)

cellular response to vascular endothelial growth factor stimulus (IEA)

endocytosis (IEA)

endothelial cell chemotaxis (IEA)

myoblast migration involved in skeletal muscle regeneration (IEA)

negative regulation of apoptotic process (IEA)

neuromuscular synaptic transmission (IEA)

peripheral nervous system development (IEA)

plasma membrane tubulation (IEA)

positive regulation of endothelial cell proliferation (IEA)

positive regulation of T cell differentiation in thymus (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

protein localization (IEA)

regulation of gamma-delta T cell differentiation (IEA)

regulation of lamellipodium assembly (IEA)

regulation of transcription by RNA polymerase II (IEA)

skeletal muscle fiber development (IEA)

skeletal muscle tissue regeneration (IEA)

unidimensional cell growth (IEA)

Cellular Component

actin cytoskeleton (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

nucleoplasm (IEA)

nucleus (IEA)

synapse (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

lipid binding (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Egr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	12,155,031 - 12,223,380 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936555	6,410,279 - 6,415,482 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0 Ensembl	NW_004936555	6,356,691 - 6,393,825 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936555	6,347,446 - 6,393,784 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EGR3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	22,687,659 - 22,693,480 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	22,687,659 - 22,693,480 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	22,545,172 - 22,550,993 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	22,601,119 - 22,606,760 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	22,601,118 - 22,606,760	NCBI
Celera	8	21,507,165 - 21,512,936 (-)	NCBI		Celera
Cytogenetic Map	8	p21.3	NCBI
HuRef	8	21,088,681 - 21,094,160 (-)	NCBI		HuRef
CHM1_1	8	22,747,408 - 22,752,963 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	22,961,911 - 22,967,732 (-)	NCBI		T2T-CHM13v2.0

Bin3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	70,337,538 - 70,375,413 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	70,337,554 - 70,375,655 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	70,100,089 - 70,137,964 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	70,100,105 - 70,138,206 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	70,499,952 - 70,538,013 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	68,835,225 - 68,873,286 (+)	NCBI		MGSCv36	mm8
Celera	14	67,640,607 - 67,678,945 (+)	NCBI		Celera
Cytogenetic Map	14	D2	NCBI
cM Map	14	36.21	NCBI

Bin3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	51,583,474 - 51,622,329 (+)	NCBI		GRCr8
mRatBN7.2	15	45,173,725 - 45,212,607 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	45,173,732 - 45,212,604 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	49,291,591 - 49,330,460 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	50,403,086 - 50,441,954 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	47,262,410 - 47,301,270 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	51,799,339 - 51,818,697 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	51,779,839 - 51,818,699 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	55,525,398 - 55,544,850 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	50,519,884 - 50,539,242 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	50,535,662 - 50,555,015 (+)	NCBI
Celera	15	44,872,895 - 44,892,253 (+)	NCBI		Celera
Cytogenetic Map	15	p11	NCBI

Bin3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	46,042,885 - 46,085,029 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	46,042,885 - 46,085,029 (-)	NCBI	ChiLan1.0	ChiLan1.0

BIN3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	41,127,684 - 41,173,953 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	16,852,857 - 16,901,510 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	21,870,784 - 21,919,077 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	18,809,582 - 18,858,912 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	18,809,582 - 18,858,912 (-)	Ensembl	panpan1.1		panPan2

BIN3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	34,615,683 - 34,659,739 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	34,615,249 - 34,659,755 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	35,205,447 - 35,249,488 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	34,825,227 - 34,869,290 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	34,825,174 - 34,869,586 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	34,771,458 - 34,815,744 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	34,625,780 - 34,669,825 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	34,781,289 - 34,825,349 (+)	NCBI		UU_Cfam_GSD_1.0

BIN3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	6,874,300 - 6,889,133 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	6,874,281 - 6,926,950 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	7,354,594 - 7,403,650 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BIN3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	20,700,664 - 20,748,775 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	20,701,390 - 20,725,210 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	21,478,444 - 21,526,859 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Bin3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	18,121,125 - 18,163,044 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	18,121,125 - 18,163,142 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005329317	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005329318	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021729119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021729127	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040292985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040292990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040292992	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040293004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002484418	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_002484419	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005737255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005737257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000011676 ⟹ ENSSTOP00000010478

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936555	6,357,618 - 6,376,844 (-)	Ensembl

Ensembl Acc Id:

ENSSTOT00000029985 ⟹ ENSSTOP00000017928

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936555	6,410,279 - 6,415,482 (-)	Ensembl

Ensembl Acc Id:

ENSSTOT00000031991 ⟹ ENSSTOP00000025328

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936555	6,356,691 - 6,393,825 (-)	Ensembl

RefSeq Acc Id:

XM_005329317 ⟹ XP_005329374

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	12,176,719 - 12,213,591 (+)	NCBI
SpeTri2.0	NW_004936555	6,356,628 - 6,393,784 (-)	NCBI

Sequence:

show sequence

CACTTCCTGGAGACTGTCTGAATCCGGAAGTGATCCCAGAGGACCGAGTTGCGGCGGAGGACCC
CGGCAGGCGGCCCAGGTTCGGGACCATGAGCTGGATTCCTTTCAAGATTGGGCAGCCCAAGAAA
CAGATTGTACCCAAAACAGTGGAGAGAGACTTTGAAAGGGAGTATGGAAAACTCCAGCAGCTGG
AGGAGCAGACCAAGAGACTGCAGAAGGACATGAAGAAGAGCACCGATGCTGACCTGGCCATGTC
GAAATCTGCCGTGAAGATATCCCTGGACTTACTTTCCAATCCCCTCTGTGAGCAAGACCAAGAC
TTTTTGAACATGGTCACAGCCTTGGACACAGCCATGAAGCGGATGGATGCCTTCAACCAAGAAA
AGGTGAACCAGATCCAAAAGACTGTGATTGAACCCTTGAAAAAGTTTGGCAGTGTCTTCCCGAG
CCTCAACATGGCAGTGAAGCGGCGGGAGCAGGCCTTGCAGGACTACAGGAGACTCCAGGCCAAG
GTGGAGAAGTACGAGGAGAAGGAAAAGACAGGACCCGTGCTGGCCAAGCTGCACCAGGCCCGAG
AAGAGCTGCGGCCTGTGCGGGATGACTTTGAGGCCAAGAACAAGCAGCTCTTGGATGAGATGCC
ACGGTTCTATGGCAGCCGACTTGACTACTTCCAGCCCAGCTTTGAGTCCCTGATCCGAGCGCAG
GTCGTGTACTACTCAGAAATGCATAAGATCTTTGGTGACCTTACCCAGCAGCTTGACCAGCCAG
GCCACTCAGATGAGCAGCGGGAGCGAGAGAACGAGGCCAAACTGAGCGAGCTCCGAGCCCTCTC
TATCGTGGCTGATGACTGAGCTTCCATCCTTCAAAGACTTCTGGGACACAGGCAACCTCTCTAG
TCTTTGCCCTTAGCAGGCACTGGCTCATGCTTCTCCCACTGGCTGCTGTTTTGGAGACAAGAGG
TGGCCCCTGCTCCACCTTGTAATCCTTTGAACTGAGTGTCTCCATTCTCTTGAGCCTGTCACCA
GGAGCCCCAAACAGGCTGCTCTCTCCTCAGATACAGGTAAGCAGTGTAGAAAAACCCTAGGGGC
TTTTTTATTTCCTGAAGAACCGTCCAGAGTATAACCTGACCTCAGGCCAGAGCAGCAGCCCCAT
GGAAGGGCCTGGGTTTTGCCATTGCAGTTGAGGGTCTTAGCCCCACTTGCGCAGCAGGGATCGC
ATCTACCTCGAGGACACATTCCTGACCCCTCGTTGCTCTTCACACCAAAGATTCTTCTGGGCAA
GGTACAGGCACAGTCCTGGGGAACAGGAGAGCCCTGTTCCTCCAGCCCCAGCAGACCCCTCACT
CCAGCATGACAAAGGCGGGCTCAGTGCAGGGACAAGCCCTCGCTCTTCCGCATTCCCTAAGTAA
CTGGGACTCGATGTTAACTATCCCCCCATGCAGCATGTGACACATCAATCCACAGGCCTCAAAG
CAAGAGCAGTGGGTTTGTGTCTAACCTGGATATCTGGAATTTTATTTTTTCAAGTAAAGTTTCC
AACAAAACATCCACCTAGTGTTGTGCTAACTTGTGGAGAGAAGGGGAGCCCCTGGTACAGCTAT
CCCAGTTCCTGCCCACTTGGCAGAGGGCCTCTGCCTGATTCCAGCAGGCAGGCAGCCTAGGGTG
CAAAGGTTCAGGCTTTCCACCTTCTGGAAAGAACTGCCAGGGTGCATACACTGGCTTAGGGCCA
GGAGGCTGGGAGGGCACCAGGCAGCCCAGAAAAGGAACGGGGAGAGCTAGGAGAACACACTGGT
TTGTTTTTGACTTTGGTTTATTTAAAAAACAAAAAGCCAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_005329318 ⟹ XP_005329375

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	12,155,031 - 12,160,237 (+)	NCBI

Sequence:

show sequence

GCTCGGGAGTGCTATGACCGGCAAACTCGCCGAGAAGCTGCCGGTGACCATGAGCAGTTTGCTA
AACCAACTGCCTGACAATTTGTACCCCGAGGAGATCCCCAGCGCGCTCAACCTCTTCTCTGGCA
GCAGCGACTCGGTGGCCCATTACAATCAGATGGCTACAGAGAATGTGATGGACATCGGTCTGAC
CAACGAGAAGCCCAACCCGGAACTCTCTTACTCGGGCTCCTTCCAGCCAGCCCCCGGCAACAAG
ACCGTGACCTACTTGGGAAAGTTCGCTTTCGACTCCCCTTCCAATTGGTGCCAGGACAACATTA
TTAGCCTCATGAGTGCCGGCATCTTGGGGGTGCCCCCGGCCTCAGGGGCGCTCAGCACGCAGAC
ATCCACCGCTAGCATGGTGCAGCCGCCGCAGGGAGACGTGGAGGCCATGTATCCGGCGTTACCC
CCTTATTCCAACTGCGGAGATCTCTACTCGGAGCCCGTATCTTTCCACGATCCCCAGGGCAACC
CCGGGCTCGCCTATTCCCCCCAGGATTACCAATCGACCAAGCCAGCCTTGGACAGCAATCTCTT
CCCCATGATTCCTGACTACAACCTGTACCACCACCCCAACGACATGGGCTCCATTCCGGAGCAC
AAGCCCTTCCAGGGCATGGACCCCATCCGGGTCAATCCGCCCCCTATCACCCCTCTGGAGACCA
TCAAGGCGTTCAAAGACAAGCAGATCCACCCGAGCTTCGGTAGCCTGCCCCAGCCGCCGCTCAC
GCTCAAGCCCATCCGGCCCCGCAAGTACCCCAACCGGCCTAGCAAGACCCCGCTCCATGAGCGG
CCCCATGCGTGCCCGGCGGAGGGCTGCGACCGCCGCTTCAGCCGCTCGGACGAGCTGACCCGGC
ATCTGCGTATCCACACGGGCCACAAGCCCTTCCAGTGCCGGATCTGCATGCGGAGCTTCAGCCG
AAGCGACCACCTCACCACTCATATCCGCACGCATACGGGCGAGAAGCCCTTTGCCTGCGAGTTC
TGCGGGCGCAAGTTTGCGCGCAGCGACGAGCGCAAGCGCCACGCCAAGATCCACCTCAAGCAAA
AGGAGAAGAAGGCGGAGAAGGGGGGTGCGCCCTCCGCGTCCTCGGCGCCCACCGTGTCTCTGGC
CCCCGTGGTCACCACCTGCGCCTGAGGCTCGGGCCCCCAGATCCCCTCTTTTCCCCTCCAGTGC
CTCCGGCTGCTCGCCTGAAGGCAGCGGGAAAGCCAGCCACGGAGGCTCAAGGGCCGCGCCCTGG
CCTCTCCATGGACGTGCGGCCCTTTGCACCCCTTCGATGCCCCCCATTCCCATCCTTTCACACC
GGCCAGCGGTCGAGGGCCAGGCTGGACGCGCCTTCCCCTCGCTGTCCCCCACTTAGCCAAGGCG
TGGGGGCGGAAAGGTGGCGTCTAGCCCGCTTTGTTCAGTTGGGATCGCCTTGATCCAGGGGCCG
CTGGGCCGCGCCAAGGACCTGCGGGGGGACTGAAGGCGGGGCCCACCCAACCCTCGCCCTACCC
AAGCACCTCACTGATTCCCCCCGGTGTGTCTCTTCCCCCTCGAAGACCCGAGAGGGGGAGGGGG
TATGGAGCGCACCAAAG

hide sequence

RefSeq Acc Id:

XM_021729119 ⟹ XP_021584794

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	12,176,734 - 12,213,591 (+)	NCBI
SpeTri2.0	NW_004936555	6,356,628 - 6,393,768 (-)	NCBI

Sequence:

show sequence

TCTGAATCCGGAAGTGATCCCAGAGGACCGAGTTGCGGCGGAGGACCCCGGCAGGCGGCCCAGG
TTCGGGACCATGAGCTGGATTCCTTTCAAGATTGGGCAGCCCAAGAAACAGATTGTACCCAAAA
CAGTGGAGAGAGACTTTGAAAGGGAGTATGGAAAACTCCAGCACCATGTCGAAATCTGCCGTGA
AGATATCCCTGGACTTACTTTCCAATCCCCTCTGTGAGCAAGACCAAGACTTTTTGAACATGGT
CACAGCCTTGGACACAGCCATGAAGCGGATGGATGCCTTCAACCAAGAAAAGGTGAACCAGATC
CAAAAGACTGTGATTGAACCCTTGAAAAAGTTTGGCAGTGTCTTCCCGAGCCTCAACATGGCAG
TGAAGCGGCGGGAGCAGGCCTTGCAGGACTACAGGAGACTCCAGGCCAAGGTGGAGAAGTACGA
GGAGAAGGAAAAGACAGGACCCGTGCTGGCCAAGCTGCACCAGGCCCGAGAAGAGCTGCGGCCT
GTGCGGGATGACTTTGAGGCCAAGAACAAGCAGCTCTTGGATGAGATGCCACGGTTCTATGGCA
GCCGACTTGACTACTTCCAGCCCAGCTTTGAGTCCCTGATCCGAGCGCAGGTCGTGTACTACTC
AGAAATGCATAAGATCTTTGGTGACCTTACCCAGCAGCTTGACCAGCCAGGCCACTCAGATGAG
CAGCGGGAGCGAGAGAACGAGGCCAAACTGAGCGAGCTCCGAGCCCTCTCTATCGTGGCTGATG
ACTGAGCTTCCATCCTTCAAAGACTTCTGGGACACAGGCAACCTCTCTAGTCTTTGCCCTTAGC
AGGCACTGGCTCATGCTTCTCCCACTGGCTGCTGTTTTGGAGACAAGAGGTGGCCCCTGCTCCA
CCTTGTAATCCTTTGAACTGAGTGTCTCCATTCTCTTGAGCCTGTCACCAGGAGCCCCAAACAG
GCTGCTCTCTCCTCAGATACAGGTAAGCAGTGTAGAAAAACCCTAGGGGCTTTTTTATTTCCTG
AAGAACCGTCCAGAGTATAACCTGACCTCAGGCCAGAGCAGCAGCCCCATGGAAGGGCCTGGGT
TTTGCCATTGCAGTTGAGGGTCTTAGCCCCACTTGCGCAGCAGGGATCGCATCTACCTCGAGGA
CACATTCCTGACCCCTCGTTGCTCTTCACACCAAAGATTCTTCTGGGCAAGGTACAGGCACAGT
CCTGGGGAACAGGAGAGCCCTGTTCCTCCAGCCCCAGCAGACCCCTCACTCCAGCATGACAAAG
GCGGGCTCAGTGCAGGGACAAGCCCTCGCTCTTCCGCATTCCCTAAGTAACTGGGACTCGATGT
TAACTATCCCCCCATGCAGCATGTGACACATCAATCCACAGGCCTCAAAGCAAGAGCAGTGGGT
TTGTGTCTAACCTGGATATCTGGAATTTTATTTTTTCAAGTAAAGTTTCCAACAAAACATCCAC
CTAGTGTTGTGCTAACTTGTGGAGAGAAGGGGAGCCCCTGGTACAGCTATCCCAGTTCCTGCCC
ACTTGGCAGAGGGCCTCTGCCTGATTCCAGCAGGCAGGCAGCCTAGGGTGCAAAGGTTCAGGCT
TTCCACCTTCTGGAAAGAACTGCCAGGGTGCATACACTGGCTTAGGGCCAGGAGGCTGGGAGGG
CACCAGGCAGCCCAGAAAAGGAACGGGGAGAGCTAGGAGAACACACTGGTTTGTTTTTGACTTT
GGTTTATTTAAAAAACAAAAAGCCAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_021729127 ⟹ XP_021584802

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	12,155,316 - 12,160,237 (+)	NCBI

Sequence:

show sequence

TTCTGTTCTCCCGGGTGGGGGCAGCCGCCGATCGGAGGGAGAGAATGTGATGGACATCGGTCTG
ACCAACGAGAAGCCCAACCCGGAACTCTCTTACTCGGGCTCCTTCCAGCCAGCCCCCGGCAACA
AGACCGTGACCTACTTGGGAAAGTTCGCTTTCGACTCCCCTTCCAATTGGTGCCAGGACAACAT
TATTAGCCTCATGAGTGCCGGCATCTTGGGGGTGCCCCCGGCCTCAGGGGCGCTCAGCACGCAG
ACATCCACCGCTAGCATGGTGCAGCCGCCGCAGGGAGACGTGGAGGCCATGTATCCGGCGTTAC
CCCCTTATTCCAACTGCGGAGATCTCTACTCGGAGCCCGTATCTTTCCACGATCCCCAGGGCAA
CCCCGGGCTCGCCTATTCCCCCCAGGATTACCAATCGACCAAGCCAGCCTTGGACAGCAATCTC
TTCCCCATGATTCCTGACTACAACCTGTACCACCACCCCAACGACATGGGCTCCATTCCGGAGC
ACAAGCCCTTCCAGGGCATGGACCCCATCCGGGTCAATCCGCCCCCTATCACCCCTCTGGAGAC
CATCAAGGCGTTCAAAGACAAGCAGATCCACCCGAGCTTCGGTAGCCTGCCCCAGCCGCCGCTC
ACGCTCAAGCCCATCCGGCCCCGCAAGTACCCCAACCGGCCTAGCAAGACCCCGCTCCATGAGC
GGCCCCATGCGTGCCCGGCGGAGGGCTGCGACCGCCGCTTCAGCCGCTCGGACGAGCTGACCCG
GCATCTGCGTATCCACACGGGCCACAAGCCCTTCCAGTGCCGGATCTGCATGCGGAGCTTCAGC
CGAAGCGACCACCTCACCACTCATATCCGCACGCATACGGGCGAGAAGCCCTTTGCCTGCGAGT
TCTGCGGGCGCAAGTTTGCGCGCAGCGACGAGCGCAAGCGCCACGCCAAGATCCACCTCAAGCA
AAAGGAGAAGAAGGCGGAGAAGGGGGGTGCGCCCTCCGCGTCCTCGGCGCCCACCGTGTCTCTG
GCCCCCGTGGTCACCACCTGCGCCTGAGGCTCGGGCCCCCAGATCCCCTCTTTTCCCCTCCAGT
GCCTCCGGCTGCTCGCCTGAAGGCAGCGGGAAAGCCAGCCACGGAGGCTCAAGGGCCGCGCCCT
GGCCTCTCCATGGACGTGCGGCCCTTTGCACCCCTTCGATGCCCCCCATTCCCATCCTTTCACA
CCGGCCAGCGGTCGAGGGCCAGGCTGGACGCGCCTTCCCCTCGCTGTCCCCCACTTAGCCAAGG
CGTGGGGGCGGAAAGGTGGCGTCTAGCCCGCTTTGTTCAGTTGGGATCGCCTTGATCCAGGGGC
CGCTGGGCCGCGCCAAGGACCTGCGGGGGGACTGAAGGCGGGGCCCACCCAACCCTCGCCCTAC
CCAAGCACCTCACTGATTCCCCCCGGTGTGTCTCTTCCCCCTCGAAGACCCGAGAGGGGGAGGG
GGTATGGAGCGCACCAAAG

hide sequence

RefSeq Acc Id:

XM_040292985 ⟹ XP_040148919

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	12,155,078 - 12,160,237 (+)	NCBI

RefSeq Acc Id:

XM_040292990 ⟹ XP_040148924

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	12,155,774 - 12,160,237 (+)	NCBI

RefSeq Acc Id:

XM_040292992 ⟹ XP_040148926

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	12,155,031 - 12,213,591 (+)	NCBI

RefSeq Acc Id:

XM_040293004 ⟹ XP_040148938

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	12,176,751 - 12,213,591 (+)	NCBI

RefSeq Acc Id:

XR_005737255

Type:

NON-CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	12,155,031 - 12,223,380 (+)	NCBI

RefSeq Acc Id:

XR_005737257

Type:

NON-CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404943	12,155,031 - 12,216,299 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005329374	(Get FASTA)	NCBI Sequence Viewer
	XP_005329375	(Get FASTA)	NCBI Sequence Viewer
	XP_021584794	(Get FASTA)	NCBI Sequence Viewer
	XP_021584802	(Get FASTA)	NCBI Sequence Viewer
	XP_040148919	(Get FASTA)	NCBI Sequence Viewer
	XP_040148924	(Get FASTA)	NCBI Sequence Viewer
	XP_040148926	(Get FASTA)	NCBI Sequence Viewer
	XP_040148938	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000010478.3
	ENSSTOP00000017928.1
	ENSSTOP00000025328.1
GenBank Protein	KAG3294376	(Get FASTA)	NCBI Sequence Viewer
	KAG3294377	(Get FASTA)	NCBI Sequence Viewer
	KAG3294378	(Get FASTA)	NCBI Sequence Viewer
	KAG3294379	(Get FASTA)	NCBI Sequence Viewer
	KAG3294380	(Get FASTA)	NCBI Sequence Viewer
	KAG3294381	(Get FASTA)	NCBI Sequence Viewer
	KAG3294382	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005329374 ⟸ XM_005329317
- Peptide Label:	isoform X5
- UniProtKB:	A0A287CVN6 (UniProtKB/TrEMBL), I3MHT3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSWIPFKIGQPKKQIVPKTVERDFEREYGKLQQLEEQTKRLQKDMKKSTDADLAMSKSAVKISL DLLSNPLCEQDQDFLNMVTALDTAMKRMDAFNQEKVNQIQKTVIEPLKKFGSVFPSLNMAVKRR EQALQDYRRLQAKVEKYEEKEKTGPVLAKLHQAREELRPVRDDFEAKNKQLLDEMPRFYGSRLD YFQPSFESLIRAQVVYYSEMHKIFGDLTQQLDQPGHSDEQRERENEAKLSELRALSIVADD hide sequence

RefSeq Acc Id:

XP_021584794 ⟸ XM_021729119

- Peptide Label:

isoform X6

- Sequence:

show sequence

MENSSTMSKSAVKISLDLLSNPLCEQDQDFLNMVTALDTAMKRMDAFNQEKVNQIQKTVIEPLK
KFGSVFPSLNMAVKRREQALQDYRRLQAKVEKYEEKEKTGPVLAKLHQAREELRPVRDDFEAKN
KQLLDEMPRFYGSRLDYFQPSFESLIRAQVVYYSEMHKIFGDLTQQLDQPGHSDEQRERENEAK
LSELRALSIVADD

hide sequence

RefSeq Acc Id:	XP_040148926 ⟸ XM_040292992
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_005329375 ⟸ XM_005329318
- Peptide Label:	isoform X2
- UniProtKB:	I3N0N2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTGKLAEKLPVTMSSLLNQLPDNLYPEEIPSALNLFSGSSDSVAHYNQMATENVMDIGLTNEKP NPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASGALSTQTSTAS MVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDYQSTKPALDSNLFPMIP DYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPSFGSLPQPPLTLKPI RPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRICMRSFSRSDHL TTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKAEKGGAPSASSAPTVSLAPVVT TCA hide sequence

RefSeq Acc Id:	XP_040148919 ⟸ XM_040292985
- Peptide Label:	isoform X3

RefSeq Acc Id:

XP_021584802 ⟸ XM_021729127

- Peptide Label:

isoform X1

- Sequence:

show sequence

MDIGLTNEKPNPELSYSGSFQPAPGNKTVTYLGKFAFDSPSNWCQDNIISLMSAGILGVPPASG
ALSTQTSTASMVQPPQGDVEAMYPALPPYSNCGDLYSEPVSFHDPQGNPGLAYSPQDYQSTKPA
LDSNLFPMIPDYNLYHHPNDMGSIPEHKPFQGMDPIRVNPPPITPLETIKAFKDKQIHPSFGSL
PQPPLTLKPIRPRKYPNRPSKTPLHERPHACPAEGCDRRFSRSDELTRHLRIHTGHKPFQCRIC
MRSFSRSDHLTTHIRTHTGEKPFACEFCGRKFARSDERKRHAKIHLKQKEKKAEKGGAPSASSA
PTVSLAPVVTTCA

hide sequence

RefSeq Acc Id:	XP_040148924 ⟸ XM_040292990
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_040148938 ⟸ XM_040293004
- Peptide Label:	isoform X7
- UniProtKB:	I3MHT3 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSSTOP00000010478 ⟸ ENSSTOT00000011676

Ensembl Acc Id:

ENSSTOP00000017928 ⟸ ENSSTOT00000029985

Ensembl Acc Id:

ENSSTOP00000025328 ⟸ ENSSTOT00000031991

Protein Domains

BAR C2H2-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000011677	Ensembl, UniProtKB/TrEMBL
	ENSSTOG00000021065	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000011676.3	UniProtKB/TrEMBL
	ENSSTOT00000029985.2	UniProtKB/TrEMBL
	ENSSTOT00000031991.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1270.60	UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	AH/BAR_dom_sf	UniProtKB/TrEMBL
	BAR_dom	UniProtKB/TrEMBL
	BIN3/RVS161-like	UniProtKB/TrEMBL
	Bin3_BAR	UniProtKB/TrEMBL
	EGR_N	UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
NCBI Gene	Bin3	ENTREZGENE
PANTHER	BRIDGING INTEGRATOR 3	UniProtKB/TrEMBL
	BRIDGING INTEGRATOR 3	UniProtKB/TrEMBL
	EARLY GROWTH RESPONSE PROTEIN 3	UniProtKB/TrEMBL
	KRUEPPEL-LIKE TRANSCRIPTION FACTOR	UniProtKB/TrEMBL
Pfam	BAR	UniProtKB/TrEMBL
	DUF3446	UniProtKB/TrEMBL
	zf-C2H2	UniProtKB/TrEMBL
PROSITE	BAR	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
SMART	BAR	UniProtKB/TrEMBL
	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF103657	UniProtKB/TrEMBL
	SSF57667	UniProtKB/TrEMBL
UniProt	A0A287CVN6	ENTREZGENE, UniProtKB/TrEMBL
	I3MHT3	ENTREZGENE, UniProtKB/TrEMBL
	I3N0N2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-26	Egr3	early growth response 3	Bin3	bridging integrator 3	Symbol and/or name change	5135510	APPROVED
2021-03-25	Bin3	bridging integrator 3	Egr3	early growth response 3	Data merged from RGD:12673106	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD