| 2541 | Efnb3 | ephrin B3 | ENCODES a protein that exhibits ephrin receptor binding (ortholog); INVOLVED IN positive regulation of presynapse assembly; positive regulation of synaptic transmission; adult walking behavior (ortholog); PARTICIPATES IN altered ephrin - ephrin receptor bidirectional signaling pathway; ephrin - ephr in receptor bidirectional signaling axis; ASSOCIATED WITH movement disease (ortholog); FOUND IN glutamatergic synapse; postsynaptic density membrane; hippocampal mossy fiber to CA3 synapse (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 10 | 54773282 | 54780727 | Rat | 111 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10509 | Efnb3 | ephrin B3 | Predicted to enable ephrin receptor binding activity. Involved in negative regulation of axonogenesis and trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission. Acts upstream of or within T cell costimulation; adult walking behavior; and axon choice point recognition. Is active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study movement disease. Orthologous to human EFNB3 (ephrin B3). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 69444918 | 69452428 | Mouse | 138 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1346330 | EFNB3 | ephrin B3 | EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008] | 17 | 7705202 | 7711372 | Human | 116 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8835204 | Efnb3 | ephrin B3 | ENCODES a protein that exhibits ephrin receptor binding (ortholog); INVOLVED IN adult walking behavior (ortholog); axon choice point recognition (ortholog); axon guidance (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH movement disease (ortholog); F OUND IN glutamatergic synapse (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog); plasma membrane (ortholog) | NW_004955467 | 9217796 | 9225223 | Chinchilla | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11977180 | EFNB3 | ephrin B3 | ENCODES a protein that exhibits ephrin receptor binding (inferred); INVOLVED IN adult walking behavior (ortholog); axon choice point recognition (ortholog); axon guidance (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH movement disease (ortholog); F OUND IN postsynaptic density membrane (ortholog) | 17 | 7737297 | 7743732 | Bonobo | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12095127 | EFNB3 | ephrin B3 | ENCODES a protein that exhibits ephrin receptor binding (inferred); histone binding (inferred); identical protein binding (inferred); INVOLVED IN adult walking behavior (ortholog); axon choice point recognition (ortholog); axon guidance (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectio nal signaling axis; ASSOCIATED WITH movement disease (ortholog); FOUND IN postsynaptic density membrane (ortholog) | 5 | 32588062 | 32592390 | Dog | 67 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12523048 | Efnb3 | ephrin B3 | ENCODES a protein that exhibits ephrin receptor binding (inferred); INVOLVED IN adult walking behavior (ortholog); axon choice point recognition (ortholog); axon guidance (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH movement disease (ortholog); F OUND IN postsynaptic density membrane (ortholog) | NW_004936595 | 954383 | 960573 | Squirrel | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14148068 | EFNB3 | ephrin B3 | ENCODES a protein that exhibits ephrin receptor binding (inferred); INVOLVED IN adult walking behavior (ortholog); axon choice point recognition (ortholog); axon guidance (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH movement disease (ortholog); F OUND IN postsynaptic density membrane (ortholog) | | | | Pig | 36 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18928011 | Efnb3 | ephrin B3 | ENCODES a protein that exhibits ephrin receptor binding (inferred); INVOLVED IN adult walking behavior (ortholog); axon choice point recognition (ortholog); axon guidance (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH movement disease (ortholog); F OUND IN glutamatergic synapse (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog); postsynaptic density membrane (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625973221 | Efnb3 | ephrin B3 | ENCODES a protein that exhibits ephrin receptor binding (ortholog); INVOLVED IN adult walking behavior (ortholog); axon choice point recognition (ortholog); axon guidance (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH movement disease (ortholog); F OUND IN glutamatergic synapse (ortholog); hippocampal mossy fiber to CA3 synapse (ortholog); plasma membrane (ortholog) | | | | Black Rat | 25 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287100657 | efnb3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18680039 | EFNB3 | ephrin B3 | ENCODES a protein that exhibits ephrin receptor binding (inferred); INVOLVED IN adult walking behavior (ortholog); axon choice point recognition (ortholog); axon guidance (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH movement disease (ortholog); F OUND IN postsynaptic density membrane (ortholog) | | | | Green Monkey | 34 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 287100603 | efnb3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863904 | efnb3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 628359136 | efnb3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405856861 | efnb3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860895 | efnb3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864365 | efnb3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12124119 | WRAP53 | WD repeat containing antisense to TP53 | ENCODES a protein that exhibits histone binding (inferred); identical protein binding (inferred); protein carrier chaperone (inferred); INVOLVED IN positive regulation of telomere maintenance via telomerase (ortholog); ASSOCIATED WITH Autosomal Recessive Dyskeratosis Congenita (ortholog); autosomal recessive dyskeratosis congenita 3 (ortholog); Body Weight (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog) | 5 | 32574153 | 32586222 | Dog | 67 | ensembl_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
