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Gene: Efnb3 (ephrin B3) Mus musculus
Symbol: Efnb3
Name: ephrin B3
RGD ID: 10509
Description: Predicted to have ephrin receptor binding activity. Involved in several processes, including adult walking behavior; generation of neurons; and trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission. Localizes to glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; heart; integumental system; and sensory organ. Used to study movement disease. Orthologous to human EFNB3 (ephrin B3); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: EFL-; EFL-6; ELF-; ELF-3; Elk-; Elk-L3; Ep; ephrin-B3; Epl8; LERK; LERK-8; NLER; NLERK-2
Homo sapiens (human) : EFNB3 (ephrin B3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Efnb3 (ephrin B3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Efnb3 (ephrin B3)
Pan paniscus (bonobo/pygmy chimpanzee) : EFNB3 (ephrin B3)
Canis lupus familiaris (dog) : EFNB3 (ephrin B3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Efnb3 (ephrin B3)
Sus scrofa (pig) : EFNB3 (ephrin B3)
Chlorocebus sabaeus (African green monkey) : EFNB3 (ephrin B3)
Heterocephalus glaber (naked mole-rat) : Efnb3 (ephrin B3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391169,444,918 - 69,452,428 (-)NCBI
GRCm381169,554,092 - 69,561,150 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,554,092 - 69,560,205 (-)EnsemblGRCm38mm10GRCm38
MGSCv371169,367,594 - 69,373,739 (-)NCBIGRCm37mm9NCBIm37
MGSCv361169,370,320 - 69,376,373 (-)NCBImm8
Celera1176,517,045 - 76,523,190 (-)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.8NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Efnb3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10509
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.