| 1303336 | Dnmt3a | DNA methyltransferase 3 alpha | ENCODES a protein that exhibits chromatin binding; DNA (cytosine-5-)-methyltransferase activity (ortholog); DNA binding (ortholog); INVOLVED IN cellular response to ethanol; cellular response to hypoxia; hepatocyte apoptotic process; PARTICIPATES IN DNA modification pathway; methionine cycle/metabol ic pathway; cysteine and methionine metabolic pathway; ASSOCIATED WITH Brain Hypoxia-Ischemia; Carcinogenesis; congenital heart disease; FOUND IN nucleus; chromosome, centromeric region (ortholog); cytoplasm (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 17alpha-ethynylestradiol | 6 | 32507316 | 32621678 | Rat | 516 | symbol , old_gene_name , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1606038 | DNMT3A | DNA methyltransferase 3 alpha | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016] | 2 | 25227874 | 25342590 | Human | 798 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1620920 | Dnmt3a | DNA methyltransferase 3A | This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012] | 12 | 3851559 | 3964442 | Mouse | 644 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 8950567 | Dnmt3a | DNA methyltransferase 3 alpha | ENCODES a protein that exhibits chromatin binding (ortholog); DNA (cytosine-5-)-methyltransferase activity (ortholog); DNA binding (ortholog); INVOLVED IN autosome genomic imprinting (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to bisphenol A (ortholog); PARTICI PATES IN DNA modification pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute monocytic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN chromosome, centromeric region (ortholog); cytoplasm (ortholog); euchromatin (ortholog) | NW_004955469 | 7264431 | 7367059 | Chinchilla | 138 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11832280 | DNMT3A | DNA methyltransferase 3 alpha | ENCODES a protein that exhibits chromatin binding (ortholog); unmethylated CpG binding (ortholog); INVOLVED IN autosome genomic imprinting (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to bisphenol A (ortholog); PARTICIPATES IN DNA modification pathway; methionin e cycle/metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute monocytic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN nucleus (ortholog) | 2A | 25229593 | 25344733 | Bonobo | 149 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12316125 | DNMT3A | DNA methyltransferase 3 alpha | ENCODES a protein that exhibits chromatin binding (ortholog); unmethylated CpG binding (ortholog); INVOLVED IN autosome genomic imprinting (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to bisphenol A (ortholog); PARTICIPATES IN DNA modification pathway; methionin e cycle/metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute monocytic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN nucleus (ortholog) | 17 | 19489524 | 19563074 | Dog | 148 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12641696 | Dnmt3a | DNA methyltransferase 3 alpha | ENCODES a protein that exhibits chromatin binding (ortholog); unmethylated CpG binding (ortholog); INVOLVED IN autosome genomic imprinting (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to bisphenol A (ortholog); PARTICIPATES IN DNA modification pathway; methionin e cycle/metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute monocytic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN nucleus (ortholog) | NW_004936493 | 6963406 | 7013256 | Squirrel | 148 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14071308 | DNMT3A | DNA methyltransferase 3 alpha | ENCODES a protein that exhibits chromatin binding (ortholog); unmethylated CpG binding (ortholog); INVOLVED IN autosome genomic imprinting (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to bisphenol A (ortholog); PARTICIPATES IN DNA modification pathway; methionin e cycle/metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute monocytic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN nucleus (ortholog); INTERACTS WITH bisphenol A; choline; cyanocob(III)alamin | | | | Pig | 158 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18674625 | DNMT3A | DNA methyltransferase 3 alpha | ENCODES a protein that exhibits chromatin binding (ortholog); unmethylated CpG binding (ortholog); INVOLVED IN autosome genomic imprinting (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to bisphenol A (ortholog); PARTICIPATES IN DNA modification pathway; methionin e cycle/metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute monocytic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN nucleus (ortholog) | | | | Green Monkey | 149 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18906181 | Dnmt3a | DNA methyltransferase 3 alpha | ENCODES a protein that exhibits chromatin binding (ortholog); lncRNA binding (ortholog); protein-cysteine methyltransferase activity (ortholog); INVOLVED IN autosome genomic imprinting (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to bisphenol A (ortholog); PARTI CIPATES IN DNA modification pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute monocytic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN chromosome, centromeric region (ortholog); euchromatin (ortholog); heterochromatin (ortholog) | | | | Naked Mole-Rat | 147 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245842 | dnmt3a | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625927484 | Dnmt3a | DNA methyltransferase 3 alpha | ENCODES a protein that exhibits chromatin binding (ortholog); DNA (cytosine-5-)-methyltransferase activity (ortholog); DNA binding (ortholog); INVOLVED IN autosome genomic imprinting (ortholog); cellular response to amino acid stimulus (ortholog); cellular response to bisphenol A (ortholog); PARTICI PATES IN DNA modification pathway; methionine cycle/metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute monocytic leukemia (ortholog); acute myeloid leukemia (ortholog); FOUND IN chromosome, centromeric region (ortholog); cytoplasm (ortholog); euchromatin (ortholog) | | | | Black Rat | 137 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 405857466 | dnmt3a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405862314 | dnmt3a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864102 | dnmt3a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405865561 | dnmt3a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626171642 | dnmt3a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626174761 | dnmt3a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 626179786 | dnmt3a.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 405857365 | dnmt3a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405860926 | dnmt3a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405863929 | dnmt3a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 405864935 | dnmt3a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 626175775 | dnmt3a.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1586201 | Dnmt3a-ps1 | DNA methyltransferase 3 alpha, pseudogene 1 | | 14 | 58981314 | 58983890 | Rat | | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1618694 | Dnmt3a-ps1 | DNA methyltransferase 3A, pseudogene 1 | | 3 | 77468121 | 77471249 | Mouse | | symbol , PhenoGen | gene, pseudo, INFERRED [RefSeq] |
| 1582845 | Dnmt3a-ps2 | DNA methyltransferase 3 alpha, pseudogene 2 | | 8 | 23591909 | 23596106 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1559691 | Dnmt3a-ps3 | DNA methyltransferase 3 alpha, pseudogene 3 | | 1 | 116288844 | 116299485 | Rat | | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 1351585 | DNMT3AP1 | DNA methyltransferase 3A pseudogene 1 | | 2 | 66819925 | 66821517 | Human | | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 1305891 | Pwwp2a | PWWP domain containing 2A | ENCODES a protein that exhibits chromatin binding (ortholog); histone binding (ortholog); histone H3K36me3 reader activity (ortholog); INVOLVED IN chromatin remodeling (ortholog); positive regulation of transcription elongation by RNA polymerase II (ortholog); regulation of transcriptional start sit e selection at RNA polymerase II promoter (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil | 10 | 28654272 | 28696693 | Rat | 73 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1624665 | Dnmt3aos | DNA methyltransferase 3A, opposite strand | INTERACTS WITH 2,4-dibromophenyl 2,4,5-tribromophenyl ether; pioglitazone; silicon dioxide | 12 | 3909293 | 3912244 | Mouse | 8 | symbol , PhenoGen | gene, ncrna, VALIDATED [RefSeq] |
| 1321014 | SALL3 | spalt like transcription factor 3 | This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importanc e in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011] | 18 | 78979818 | 78998969 | Human | 73 | description | gene, protein-coding, VALIDATED [RefSeq] |