| 1303182 | Dctn2 | dynactin subunit 2 | ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase binding (ortholog); spectrin binding (ortholog); INVOLVED IN melanosome transport (ortholog); microtubule-based process (ortholog); mitotic metaphase chromosome alignment (ortholog); PARTICIPATES IN mitochondria tra nsport pathway; Huntington's disease pathway; vasopressin signaling pathway via receptor type 2; ASSOCIATED WITH synucleinopathy; Charcot-Marie-Tooth disease (ortholog); FOUND IN centrosome; dynactin complex; kinetochore; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; bisphenol A | 7 | 64977338 | 64992875 | Rat | 100 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1352908 | DCTN2 | dynactin subunit 2 | This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripeta l movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012] | 12 | 57530051 | 57547192 | Human | 117 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1553080 | Dctn2 | dynactin 2 | Predicted to enable identical protein binding activity; protein kinase binding activity; and spectrin binding activity. Acts upstream of or within melanosome transport. Located in growth cone. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system; nervo us system; and reproductive system. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Jul 2025] | 10 | 127102131 | 127117828 | Mouse | 111 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8924457 | Dctn2 | dynactin subunit 2 | ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase binding (ortholog); spectrin binding (ortholog); INVOLVED IN melanosome transport (ortholog); microtubule-based process (ortholog); mitotic metaphase chromosome alignment (ortholog); PARTICIPATES IN mitochondria tra nsport pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); synucleinopathy (ortholog); FOUND IN centrosome (ortholog); ciliary basal body (ortholog); dynactin complex (ortholog) | NW_004955458 | 5247871 | 5264424 | Chinchilla | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11868510 | DCTN2 | dynactin subunit 2 | ENCODES a protein that exhibits identical protein binding (inferred); protein kinase binding (inferred); spectrin binding (inferred); INVOLVED IN melanosome transport (ortholog); protein localization to centrosome (ortholog); PARTICIPATES IN mitochondria transport pathway; ASSOCIATED WITH Charcot-Ma rie-Tooth disease (ortholog); synucleinopathy (ortholog); FOUND IN centrosome (ortholog); dynactin complex (ortholog); kinetochore (ortholog) | 12 | 31379531 | 31396570 | Bonobo | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12272725 | DCTN2 | dynactin subunit 2 | ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase binding (ortholog); spectrin binding (ortholog); INVOLVED IN melanosome transport (ortholog); mitotic metaphase chromosome alignment (ortholog); protein localization to centrosome (ortholog); PARTICIPATES IN mitocho ndria transport pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); synucleinopathy (ortholog); FOUND IN centrosome (ortholog); ciliary basal body (ortholog); dynactin complex (ortholog) | 10 | 1620702 | 1634385 | Dog | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12529028 | Dctn2 | dynactin subunit 2 | ENCODES a protein that exhibits identical protein binding (inferred); protein kinase binding (inferred); spectrin binding (inferred); INVOLVED IN melanosome transport (ortholog); protein localization to centrosome (ortholog); PARTICIPATES IN mitochondria transport pathway; ASSOCIATED WITH Charcot-Ma rie-Tooth disease (ortholog); synucleinopathy (ortholog); FOUND IN centrosome (ortholog); dynactin complex (ortholog); kinetochore (ortholog) | NW_004936646 | 1678678 | 1695142 | Squirrel | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155239748 | dctn2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18760520 | DCTN2 | dynactin subunit 2 | ENCODES a protein that exhibits identical protein binding (inferred); protein kinase binding (inferred); spectrin binding (inferred); INVOLVED IN melanosome transport (ortholog); protein localization to centrosome (ortholog); PARTICIPATES IN mitochondria transport pathway; ASSOCIATED WITH Charcot-Ma rie-Tooth disease (ortholog); synucleinopathy (ortholog); FOUND IN centrosome (ortholog); dynactin complex (ortholog); kinetochore (ortholog) | | | | Green Monkey | 44 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625925224 | Dctn2 | dynactin subunit 2 | ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase binding (ortholog); spectrin binding (ortholog); INVOLVED IN melanosome transport (ortholog); microtubule-based process (ortholog); mitotic metaphase chromosome alignment (ortholog); PARTICIPATES IN mitochondria tra nsport pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); synucleinopathy (ortholog); FOUND IN centrosome (ortholog); ciliary basal body (ortholog); dynactin complex (ortholog) | | | | Black Rat | 41 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14140541 | DCTN2 | dynactin subunit 2 | ENCODES a protein that exhibits identical protein binding (inferred); protein kinase binding (inferred); spectrin binding (inferred); INVOLVED IN microtubule-based process; melanosome transport (ortholog); protein localization to centrosome (ortholog); PARTICIPATES IN mitochondria transport pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); synucleinopathy (ortholog); FOUND IN centrosome (ortholog); dynactin complex (ortholog); kinetochore (ortholog) | | | | Pig | 53 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18924001 | Dctn2 | dynactin subunit 2 | ENCODES a protein that exhibits identical protein binding (ortholog); protein kinase binding (ortholog); spectrin binding (ortholog); INVOLVED IN melanosome transport (ortholog); mitotic metaphase chromosome alignment (ortholog); mitotic spindle organization (ortholog); PARTICIPATES IN mitochondria transport pathway; ASSOCIATED WITH Charcot-Marie-Tooth disease (ortholog); synucleinopathy (ortholog); FOUND IN centrosome (ortholog); ciliary basal body (ortholog); dynactin complex (ortholog) | | | | Naked Mole-Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250027 | dctn2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155252481 | dctn2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 14377683 | DCTN2-p50 | | | | | | Fly | | symbol | gene, null |
| 1319944 | DCTN3 | dynactin subunit 3 | This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripe tal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] | 9 | 34613546 | 34620495 | Human | 82 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |