| 2446 | Ctse | cathepsin E | ENCODES a protein that exhibits aspartic-type endopeptidase activity; identical protein binding (ortholog); peptidase activity (ortholog); INVOLVED IN antigen processing and presentation of exogenous peptide antigen via MHC class II; protein autoprocessing; proteolysis (ortholog); ASSOCIATED WITH at opic dermatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endosome; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 13 | 45644168 | 45666722 | Rat | 130 | symbol , old_gene_name , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10422 | Ctse | cathepsin E | This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015] | 1 | 131566052 | 131603245 | Mouse | 153 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 736046 | CTSE | cathepsin E | This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. [provided by RefSeq, Nov 2015] | 1 | 206009264 | 206023895 | Human | 127 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8859537 | Ctse | cathepsin E | ENCODES a protein that exhibits aspartic-type endopeptidase activity (ortholog); identical protein binding (ortholog); peptidase activity (ortholog); INVOLVED IN antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); protein autoprocessing (ortholog); proteolys is (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endosome (ortholog) | NW_004955406 | 41641412 | 41653261 | Chinchilla | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12042739 | CTSE | cathepsin E | ENCODES a protein that exhibits aspartic-type endopeptidase activity (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN protein autoprocessing (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experi mental Liver Cirrhosis (ortholog); FOUND IN endosome (inferred) | 1 | 181617421 | 181632260 | Bonobo | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12284307 | CTSE | cathepsin E | ENCODES a protein that exhibits aspartic-type endopeptidase activity (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN protein autoprocessing (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experi mental Liver Cirrhosis (ortholog); FOUND IN endosome (inferred) | 38 | 2368711 | 2380554 | Dog | 24 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12614463 | Ctse | cathepsin E | ENCODES a protein that exhibits aspartic-type endopeptidase activity (inferred); endopeptidase activity (inferred); hydrolase activity (inferred); INVOLVED IN protein autoprocessing (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experimen tal Liver Cirrhosis (ortholog); FOUND IN endosome (inferred) | NW_004936557 | 6485783 | 6498805 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155232062 | ctse | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18569994 | CTSE | cathepsin E | ENCODES a protein that exhibits aspartic-type endopeptidase activity (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN protein autoprocessing (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experi mental Liver Cirrhosis (ortholog); FOUND IN endosome (inferred); extracellular region (inferred) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18911346 | Ctse | cathepsin E | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN protein autoprocessing (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endosome (inferred) | | | | Naked Mole-Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625853623 | Ctse | cathepsin E | ENCODES a protein that exhibits aspartic-type endopeptidase activity (ortholog); identical protein binding (ortholog); peptidase activity (ortholog); INVOLVED IN antigen processing and presentation of exogenous peptide antigen via MHC class II (ortholog); protein autoprocessing (ortholog); proteolys is (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN endosome (ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240286 | ctse.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155232061 | ctse.S | | | | | | African Clawed Frog | | symbol | gene, null |
