Ctse (cathepsin E) - Rat Genome Database

Name: Ctse
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ctse (cathepsin E) Ictidomys tridecemlineatus

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Symbol:

Ctse

Name:

cathepsin E

RGD ID:

12614463

Description:

ENCODES a protein that exhibits aspartic-type endopeptidase activity (inferred); endopeptidase activity (inferred); identical protein binding (inferred); INVOLVED IN protein autoprocessing (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); autistic disorder (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN endosome (inferred); intracellular membrane-bounded organelle (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CTSE (cathepsin E)	NCBI	Ortholog
Mus musculus (house mouse):	Ctse (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ctse (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ctse (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CTSE (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CTSE (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CTSE (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ctse (cathepsin E)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	69,245,473 - 69,258,551 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	6,485,755 - 6,498,833 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	6,485,783 - 6,498,805 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atopic dermatitis (ISO)

autistic disorder (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Experimental Liver Cirrhosis (ISO)

familial adult myoclonic epilepsy 5 (ISO)

gastrointestinal stromal tumor (ISO)

Hypokalemic Periodic Paralysis, Type 1 (ISO)

parathyroid carcinoma (ISO)

prostate cancer (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antigen processing and presentation of exogenous peptide antigen via MHC class II (IEA)

protein autoprocessing (ISO)

proteolysis (IEA)

Cellular Component

endosome (IEA)

intracellular membrane-bounded organelle (IEA)

Molecular Function

aspartic-type endopeptidase activity (IEA)

endopeptidase activity (IEA)

identical protein binding (IEA)

peptidase activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ctse
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	69,245,473 - 69,258,551 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	6,485,755 - 6,498,833 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	6,485,783 - 6,498,805 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CTSE
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	206,009,264 - 206,023,895 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	206,008,535 - 206,023,909 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	206,317,473 - 206,332,104 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	204,484,082 - 204,498,727 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	179,116,519 - 179,131,198 (-)	NCBI		Celera
Cytogenetic Map	1	q32.1	NCBI
HuRef	1	177,247,760 - 177,262,405 (+)	NCBI		HuRef
T2T-CHM13v2.0	1	205,273,263 - 205,287,895 (-)	NCBI		T2T-CHM13v2.0

Ctse
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	131,566,052 - 131,603,245 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	131,566,044 - 131,603,243 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	131,638,314 - 131,675,507 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	131,638,306 - 131,675,505 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	133,534,891 - 133,572,084 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	133,465,860 - 133,503,049 (+)	NCBI		MGSCv36	mm8
Celera	1	134,250,340 - 134,281,876 (+)	NCBI		Celera
Cytogenetic Map	1	E4	NCBI
cM Map	1	57.14	NCBI

Ctse
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	45,644,168 - 45,666,722 (+)	NCBI		GRCr8
mRatBN7.2	13	43,091,954 - 43,114,509 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	43,092,128 - 43,114,502 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	45,695,406 - 45,717,865 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	46,983,544 - 47,006,003 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	44,248,051 - 44,270,572 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	48,426,833 - 48,449,493 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	48,426,820 - 48,449,490 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	53,498,965 - 53,521,605 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	44,582,911 - 44,605,241 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	44,596,953 - 44,619,284 (+)	NCBI
Celera	13	43,430,588 - 43,452,924 (+)	NCBI		Celera
Cytogenetic Map	13	q13	NCBI

Ctse
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	41,641,311 - 41,653,296 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	41,641,412 - 41,653,261 (-)	NCBI	ChiLan1.0	ChiLan1.0

CTSE
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	43,346,170 - 43,361,406 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	43,311,665 - 43,326,899 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	181,617,421 - 181,632,260 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	185,900,746 - 185,915,368 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	185,900,746 - 185,915,519 (-)	Ensembl	panpan1.1		panPan2

CTSE
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	2,368,711 - 2,380,554 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	2,369,265 - 2,380,459 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	2,461,257 - 2,473,099 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	2,365,859 - 2,377,730 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	2,365,857 - 2,377,890 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	2,359,989 - 2,371,820 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	2,751,514 - 2,763,344 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	2,952,739 - 2,964,581 (-)	NCBI		UU_Cfam_GSD_1.0

CTSE
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	23,318,421 - 23,333,885 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	23,319,248 - 23,332,980 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	24,017,015 - 24,031,766 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ctse
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	5,291,736 - 5,305,104 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	5,291,993 - 5,306,507 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021729257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000009582 ⟹ ENSSTOP00000008595

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936557	6,485,878 - 6,498,219 (+)	Ensembl

Ensembl Acc Id:

ENSSTOT00000042898 ⟹ ENSSTOP00000031798

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936557	6,485,755 - 6,498,833 (+)	Ensembl

RefSeq Acc Id:

XM_021729257 ⟹ XP_021584932

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409344	69,245,473 - 69,258,551 (+)	NCBI
SpeTri2.0	NW_004936557	6,485,783 - 6,498,805 (+)	NCBI

Sequence:

show sequence

CTTAACACACTCTGTCCTCACTCTGTGTGAGAGAAGGAAAGAGAGGGTGAAGCAGACTCCAGTG
GGGAGAGAGAGAAGCTGCTGGTTGGACCACAATGAAAACCCTCCTCCTGCTGCTGCTCGCGCTT
CTCGACCTGGGACAGGCCCAAGGAGCCCTTCACAGGGTGGCCCTCAAGAGGCACCAGTCCCTCC
GGAAGAAGCTGCGGGCCCGGGGCCAGCTCTCCGAGTTCTGGAAATCCCAGAACTTGGACATGAT
CCAGTTCACCGAATCCTGCACCAAGGACCAGGGCACCAACGAGCCCCTCATCAACTACTTGGAT
GTAGAATACTTTGGCACTATCTCCATTGGCTCCCCACCACAGAACTTCACTGTCATCTTTGACA
CTGGCTCCTCCAATCTCTGGGTCCCCTCTGTGTACTGCACCAGCCCAGCCTGCAAGTCACACCC
CGTGTTCCACCCCTCCCAGTCCAACACATACAGTGAGCTGGGCACTTCTTTCTCCATTCAGTAT
GGGACCGGGAGCTTGTCTGGGATCATCGGAGCCGACCAAGTCACTGTAGGAGGACTGACTGTGA
TTGGCCAGCAGTTTGGAGAAAGTGTCAAAGAGCCGGGCCAGACCTTTGTGAATGCAGAGTTTGA
TGGAATCCTGGGTTTGGGATACCCTTCCTTGGCTGCTGGAGGTGTGACTCCAGTATTTGACAAC
ATGATGGCCCAGAACCTAGTGGATCTGCCCATATTTTCTGTCTACATGAGCAGTGACCCACAAG
GTGGCTCAAGTAGTGAGCTGACGTTCGGAGGCTATGACAGCTCTCATTTCTCCGGGAGCCTGAA
TTGGGTCCCGGTCACCAAGCAAGCCTACTGGCAGATTGCGCTGGATAAAATCCTGGTGGGAGAC
ACTGTGACATTCTGCTCTGAGGGCTGCCAGGCCATTGTGGACACAGGGACCTCCCTCATCACTG
GCCCTTCCCACAAGATCAAGCAGCTGCAGGAGGCCATTGGGGCGGCGCCCATGGATGGAGAGTA
CACCGTGGAGTGTGCCAACCTCAGCGACATGCCAGATATCACTTTCATCATCAACGGCGTCTCC
TACACCCTCAGCCCAACTGCCTACACGCTGCTGGACTTTGTGGATGGAATGAAGTTGTGCAGCA
GTGGCTTTCAAGGACTCGACATCCAGCCTCCATCTGGGCCTCTCTGGATCCTGGGCGATGTCTT
CATTCGGCAGTTTTACTCAGTCTTTGATCGTGGAAATAACCGCGTGGGGCTCGCCCCAGCAGTC
CCTTGAGCAGGGCTCCTGTCTCTGCCTGTCTACCTGGCAACCCCCGGGCCTGTGAGGTTAGGGC
ATTCTCTACACCTGTCAGCAGGGCCTTTCCCTCAGAAAACAGTTGTTCCCAGAATTGCAACTTG
AATTTGGACAAATGGAGCATGAGAGCACACACACACGCATACACAACCTCACTCACACTTCACA
CACACACACACACACACACACCAAATCAACCACCATCGTGGCAGAAGAATTAAGTTGTGAGTCC
ATATTCTTTATTGCTTTTTTTGTTGAATTTTTATCACAGAAATCTCCAAACATATACACAGTAG
AGGTTGTGATCCAGTAAGTCCCTACACACCCCAACCAACTTTACCAACACATCCACACACGGCC
AGGACCCCTTCATCCATATCACCATCCACTTCTCTCTCTCTAGCTCCACAAACTTGGATTATTT
TGAAACAAATTCCAAGAATCACATCATTTTATCCATAAATATTTCTATCATCCTCACACATCCA
ATTGTGATTCAGATATCTCTCATTGCCTCCTAAATGTGTGACCATTTATACAGTTGGCTTGTTT
GTATCAGCATTCAAAC

hide sequence

Protein Sequences


Protein RefSeqs	XP_021584932	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000008595.3
	ENSSTOP00000031798.1
GenBank Protein	KAG3258270	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021584932 ⟸ XM_021729257

- UniProtKB:

A0A287DE23 (UniProtKB/TrEMBL), I3MDT9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKTLLLLLLALLDLGQAQGALHRVALKRHQSLRKKLRARGQLSEFWKSQNLDMIQFTESCTKDQ
GTNEPLINYLDVEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKSHPVFHPSQSNTY
SELGTSFSIQYGTGSLSGIIGADQVTVGGLTVIGQQFGESVKEPGQTFVNAEFDGILGLGYPSL
AAGGVTPVFDNMMAQNLVDLPIFSVYMSSDPQGGSSSELTFGGYDSSHFSGSLNWVPVTKQAYW
QIALDKILVGDTVTFCSEGCQAIVDTGTSLITGPSHKIKQLQEAIGAAPMDGEYTVECANLSDM
PDITFIINGVSYTLSPTAYTLLDFVDGMKLCSSGFQGLDIQPPSGPLWILGDVFIRQFYSVFDR
GNNRVGLAPAVP

hide sequence

Ensembl Acc Id:

ENSSTOP00000008595 ⟸ ENSSTOT00000009582

Ensembl Acc Id:

ENSSTOP00000031798 ⟸ ENSSTOT00000042898

Protein Domains

Peptidase A1

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000009579	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000009582.3	UniProtKB/TrEMBL
	ENSSTOT00000042898.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.70.10	UniProtKB/TrEMBL
	6.10.140.60	UniProtKB/TrEMBL
InterPro	Aspartic_peptidase_A1	UniProtKB/TrEMBL
	Aspartic_peptidase_AS	UniProtKB/TrEMBL
	Aspartic_peptidase_N	UniProtKB/TrEMBL
	PEPTIDASE_A1	UniProtKB/TrEMBL
	Peptidase_aspartic_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Ctse	ENTREZGENE
PANTHER	PTHR47966	UniProtKB/TrEMBL
	PTHR47966:SF26	UniProtKB/TrEMBL
Pfam	A1_Propeptide	UniProtKB/TrEMBL
	Asp	UniProtKB/TrEMBL
PRINTS	PEPSIN	UniProtKB/TrEMBL
PROSITE	ASP_PROTEASE	UniProtKB/TrEMBL
	PEPTIDASE_A1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50630	UniProtKB/TrEMBL
UniProt	A0A287DE23	ENTREZGENE, UniProtKB/TrEMBL
	I3MDT9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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