CTSE (cathepsin E) - Rat Genome Database

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Gene: CTSE (cathepsin E) Canis lupus familiaris
Analyze
Symbol: CTSE
Name: cathepsin E
RGD ID: 12284307
Description: ENCODES a protein that exhibits aspartic-type endopeptidase activity (inferred); hydrolase activity (inferred); identical protein binding (inferred); INVOLVED IN protein autoprocessing (ortholog); ASSOCIATED WITH atopic dermatitis (ortholog); autistic disorder (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN endosome (inferred); intracellular membrane-bounded organelle (inferred)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,368,711 - 2,380,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl382,369,265 - 2,380,459 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,461,257 - 2,473,099 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0382,365,859 - 2,377,730 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,365,857 - 2,377,890 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,359,989 - 2,371,820 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,751,514 - 2,763,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0382,952,739 - 2,964,581 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CTSE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,368,711 - 2,380,554 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl382,369,265 - 2,380,459 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,461,257 - 2,473,099 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0382,365,859 - 2,377,730 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl382,365,857 - 2,377,890 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1382,359,989 - 2,371,820 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0382,751,514 - 2,763,344 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0382,952,739 - 2,964,581 (-)NCBIUU_Cfam_GSD_1.0
CTSE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,009,264 - 206,023,895 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,008,535 - 206,023,909 (-)EnsemblGRCh38hg38GRCh38
GRCh371206,317,473 - 206,332,104 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,484,082 - 204,498,727 (+)NCBINCBI36Build 36hg18NCBI36
Celera1179,116,519 - 179,131,198 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,247,760 - 177,262,405 (+)NCBIHuRef
T2T-CHM13v2.01205,273,263 - 205,287,895 (-)NCBIT2T-CHM13v2.0
Ctse
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,566,052 - 131,603,245 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1131,566,044 - 131,603,243 (+)EnsemblGRCm39 Ensembl
GRCm381131,638,314 - 131,675,507 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,638,306 - 131,675,505 (+)EnsemblGRCm38mm10GRCm38
MGSCv371133,534,891 - 133,572,084 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361133,465,860 - 133,503,049 (+)NCBIMGSCv36mm8
Celera1134,250,340 - 134,281,876 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.14NCBI
Ctse
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,644,168 - 45,666,722 (+)NCBIGRCr8
mRatBN7.21343,091,954 - 43,114,509 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1343,092,128 - 43,114,502 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,695,406 - 45,717,865 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,983,544 - 47,006,003 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01344,248,051 - 44,270,572 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01348,426,833 - 48,449,493 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1348,426,820 - 48,449,490 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01353,498,965 - 53,521,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41344,582,911 - 44,605,241 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11344,596,953 - 44,619,284 (+)NCBI
Celera1343,430,588 - 43,452,924 (+)NCBICelera
Cytogenetic Map13q13NCBI
Ctse
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540641,641,311 - 41,653,296 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540641,641,412 - 41,653,261 (-)NCBIChiLan1.0ChiLan1.0
CTSE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2143,346,170 - 43,361,406 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1143,311,665 - 43,326,899 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01181,617,421 - 181,632,260 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11185,900,746 - 185,915,368 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1185,900,746 - 185,915,519 (-)Ensemblpanpan1.1panPan2
Ctse
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934469,245,473 - 69,258,551 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365576,485,755 - 6,498,833 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365576,485,783 - 6,498,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CTSE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12523,318,421 - 23,333,885 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2523,319,248 - 23,332,980 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605524,017,015 - 24,031,766 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctse
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248075,291,736 - 5,305,104 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248075,291,993 - 5,306,507 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CTSE
122 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3
Low 2 2 3 2 1 5
Below cutoff 5 5 20 4 4 6 5 11 3 5 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000016203   ⟹   ENSCAFP00000014987
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl382,369,265 - 2,380,459 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000090013   ⟹   ENSCAFP00000064079
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl382,369,265 - 2,380,459 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845049246   ⟹   ENSCAFP00845038648
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl382,365,857 - 2,377,890 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845049325   ⟹   ENSCAFP00845038707
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl382,365,857 - 2,377,890 (-)Ensembl
RefSeq Acc Id: XM_005640805   ⟹   XP_005640862
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1382,368,711 - 2,380,554 (-)NCBI
Dog10K_Boxer_Tasha382,461,257 - 2,473,099 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038448147   ⟹   XP_038304075
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0382,365,859 - 2,377,730 (-)NCBI
RefSeq Acc Id: XM_038448148   ⟹   XP_038304076
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0382,365,859 - 2,377,730 (-)NCBI
RefSeq Acc Id: XM_038522624   ⟹   XP_038378552
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1382,359,989 - 2,371,820 (-)NCBI
RefSeq Acc Id: XM_038522625   ⟹   XP_038378553
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1382,359,989 - 2,371,820 (-)NCBI
RefSeq Acc Id: XM_038585909   ⟹   XP_038441837
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0382,952,739 - 2,964,581 (-)NCBI
RefSeq Acc Id: XM_038585910   ⟹   XP_038441838
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0382,952,739 - 2,964,581 (-)NCBI
RefSeq Acc Id: XM_038650291   ⟹   XP_038506219
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0382,751,514 - 2,763,344 (-)NCBI
RefSeq Acc Id: XM_038650292   ⟹   XP_038506220
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0382,751,514 - 2,763,344 (-)NCBI
RefSeq Acc Id: XM_545694   ⟹   XP_545694
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1382,368,711 - 2,380,552 (-)NCBI
Dog10K_Boxer_Tasha382,461,257 - 2,473,099 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005640862   ⟸   XM_005640805
- Peptide Label: isoform X2
- UniProtKB: A0A8C0T3R3 (UniProtKB/TrEMBL),   A0A8I3PVL6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_545694   ⟸   XM_545694
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MNS6 (UniProtKB/TrEMBL),   A0A8I3SB35 (UniProtKB/TrEMBL),   A0A8C0JVF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000014987   ⟸   ENSCAFT00000016203
RefSeq Acc Id: ENSCAFP00000064079   ⟸   ENSCAFT00000090013
RefSeq Acc Id: XP_038378553   ⟸   XM_038522625
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038378552   ⟸   XM_038522624
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038506220   ⟸   XM_038650292
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038506219   ⟸   XM_038650291
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038304076   ⟸   XM_038448148
- Peptide Label: isoform X2
- UniProtKB: A0A8C0T3R3 (UniProtKB/TrEMBL),   A0A8I3PVL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038304075   ⟸   XM_038448147
- Peptide Label: isoform X1
- UniProtKB: A0A8C0MNS6 (UniProtKB/TrEMBL),   A0A8I3SB35 (UniProtKB/TrEMBL),   A0A8C0JVF7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038441838   ⟸   XM_038585910
- Peptide Label: isoform X2
- UniProtKB: A0A8C0T3R3 (UniProtKB/TrEMBL),   A0A8I3PVL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038441837   ⟸   XM_038585909
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JVF7 (UniProtKB/TrEMBL),   A0A8C0MNS6 (UniProtKB/TrEMBL),   A0A8I3SB35 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845038648   ⟸   ENSCAFT00845049246
RefSeq Acc Id: ENSCAFP00845038707   ⟸   ENSCAFT00845049325
Protein Domains
Peptidase A1

Promoters
RGD ID:13689183
Promoter ID:EPDNEW_C7252
Type:multiple initiation site
Name:CTSE_1
Description:cathepsin E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1382,380,533 - 2,380,593EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010206 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030007849 UniProtKB/TrEMBL
  ENSCAFG00040018895 UniProtKB/TrEMBL
  ENSCAFG00845027891 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016203.5 UniProtKB/TrEMBL
  ENSCAFT00000090013.2 UniProtKB/TrEMBL
  ENSCAFT00030014507.1 UniProtKB/TrEMBL
  ENSCAFT00030014579.1 UniProtKB/TrEMBL
  ENSCAFT00030014602.1 UniProtKB/TrEMBL
  ENSCAFT00040035027.1 UniProtKB/TrEMBL
  ENSCAFT00040035114.1 UniProtKB/TrEMBL
  ENSCAFT00845049246 ENTREZGENE
  ENSCAFT00845049246.1 UniProtKB/TrEMBL
  ENSCAFT00845049325 ENTREZGENE
  ENSCAFT00845049325.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.70.10 UniProtKB/TrEMBL
  6.10.140.60 UniProtKB/TrEMBL
InterPro Aspartic_peptidase_A1 UniProtKB/TrEMBL
  Aspartic_peptidase_AS UniProtKB/TrEMBL
  Aspartic_peptidase_N UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
  Peptidase_aspartic_dom_sf UniProtKB/TrEMBL
KEGG Report cfa:488577 UniProtKB/TrEMBL
NCBI Gene CTSE ENTREZGENE
PANTHER PTHR47966 UniProtKB/TrEMBL
  PTHR47966:SF26 UniProtKB/TrEMBL
Pfam A1_Propeptide UniProtKB/TrEMBL
  Asp UniProtKB/TrEMBL
PRINTS PEPSIN UniProtKB/TrEMBL
PROSITE ASP_PROTEASE UniProtKB/TrEMBL
  PEPTIDASE_A1 UniProtKB/TrEMBL
Superfamily-SCOP SSF50630 UniProtKB/TrEMBL
UniProt A0A8C0JVF7 ENTREZGENE
  A0A8C0MNS6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0MNZ3_CANLF UniProtKB/TrEMBL
  A0A8C0T3R3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PVL6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3SB35 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39710 ENTREZGENE