| 1343269 | CLGN | calmegin | Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility. [provided by RefSeq, Jul 2008] | 4 | 140388453 | 140427648 | Human | 140 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1592643 | Clgn | calmegin | ENCODES a protein that exhibits calcium ion binding (ortholog); protein folding chaperone (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); protein-containing complex assembly (ortholog); single fertilization (ortholog); ASSOCIATED WITH Dwarfism (ortholog); FOUND IN endoplasmic reticulum (ortholog); nuclear envelope (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran; 3,7-dihydropurine-6-thione | 19 | 41601568 | 41633207 | Rat | 139 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1616006 | Clgn | calmegin | This gene belongs to the calreticulin family, which includes calreticulin, calnexin, and calmegin, and encodes a calcium-binding molecular chaperone specifically expressed in pachytene stage male germ cells. It is required for the proper folding of newly synthesized membrane proteins in the endoplas mic reticulum including those critical for sperm migration from the uterus into the oviduct and sperm adhesion to and penetration of the zona pellucida. This gene plays a key role in spermatogenesis and male infertility. Alternative splice variants exist for this gene. [provided by RefSeq, Jul 2016] | 8 | 84116454 | 84155181 | Mouse | 138 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8868008 | Clgn | calmegin | ENCODES a protein that exhibits calcium ion binding (ortholog); protein folding chaperone (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); protein-containing complex assembly (ortholog); single fertilization (ortholog); ASSOCIATED WITH Dwarfism (ortholog); FOUND IN endoplasmic reticulum (ortholog); nuclear envelope (ortholog) | NW_004955428 | 3359231 | 3406221 | Chinchilla | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11722338 | CLGN | calmegin | ENCODES a protein that exhibits calcium ion binding (inferred); protein folding chaperone (inferred); unfolded protein binding (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); protein-containing complex assembly (ortholog); single fertilization (ortholog); ASSOCIATED WITH Dwarf ism (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); nuclear envelope (inferred) | 4 | 132756193 | 132794805 | Bonobo | 22 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12388885 | CLGN | calmegin | ENCODES a protein that exhibits calcium ion binding (inferred); metal ion binding (inferred); protein folding chaperone (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); protein-containing complex assembly (ortholog); single fertilization (ortholog); ASSOCIATED WITH Dwarfism (or tholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); nuclear envelope (inferred) | 19 | 2397122 | 2445878 | Dog | 21 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 12607113 | Clgn | calmegin | ENCODES a protein that exhibits calcium ion binding (inferred); protein folding chaperone (inferred); unfolded protein binding (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); protein-containing complex assembly (ortholog); single fertilization (ortholog); ASSOCIATED WITH Dwarf ism (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); nuclear envelope (inferred) | NW_004936535 | 7358960 | 7399535 | Squirrel | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625832438 | Clgn | calmegin | ENCODES a protein that exhibits calcium ion binding (ortholog); protein folding chaperone (ortholog); INVOLVED IN binding of sperm to zona pellucida (ortholog); protein-containing complex assembly (ortholog); single fertilization (ortholog); ASSOCIATED WITH Dwarfism (ortholog); FOUND IN endoplasmic reticulum (ortholog); nuclear envelope (ortholog) | | | | Black Rat | 11 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18906418 | Clgn | calmegin | ENCODES a protein that exhibits calcium ion binding (inferred); protein folding chaperone (inferred); unfolded protein binding (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); protein-containing complex assembly (ortholog); single fertilization (ortholog); ASSOCIATED WITH Dwarf ism (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); nuclear envelope (inferred) | | | | Naked Mole-Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18563750 | CLGN | calmegin | ENCODES a protein that exhibits calcium ion binding (inferred); protein folding chaperone (inferred); unfolded protein binding (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); protein-containing complex assembly (ortholog); single fertilization (ortholog); ASSOCIATED WITH Dwarf ism (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); nuclear envelope (inferred) | | | | Green Monkey | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13936343 | CLGN | calmegin | ENCODES a protein that exhibits calcium ion binding (inferred); protein folding chaperone (inferred); unfolded protein binding (inferred); INVOLVED IN binding of sperm to zona pellucida (ortholog); protein-containing complex assembly (ortholog); single fertilization (ortholog); ASSOCIATED WITH Dwarf ism (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); nuclear envelope (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 21 | symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 284171522 | clgn | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 285711571 | clgn.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 284019294 | clgn.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1307917 | Mmp1 | matrix metallopeptidase 1 | ENCODES a protein that exhibits peptidase activity; endopeptidase activity (ortholog); metalloendopeptidase activity (ortholog); INVOLVED IN cellular response to alkaloid; cellular response to fluid shear stress; cellular response to interleukin-1; PARTICIPATES IN atherosclerosis pathway; endothelin signaling pathway; syndecan signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease; congestive heart failure; degenerative disc disease; FOUND IN extracellular space; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; alpha-naphthoflavone | 8 | 12943453 | 12963966 | Rat | 576 | old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1317388 | MMP1 | matrix metallopeptidase 1 | This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease proce sses, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] | 11 | 102789919 | 102798160 | Human | 674 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
