Clec7a Gene Search Result

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12 records found for search term Clec7a

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
1350458	CLEC7A	C-type lectin domain containing 7A	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It fun ... (more) ctions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]	12	10116777	10130304	Human	275	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
1558559	Clec7a	C-type lectin domain family 7, member a	Enables (1->3)-beta-D-glucan binding activity; (1->3)-beta-D-glucan immune receptor activity; and opsonin binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and response to fungus. Acts upst ... (more) ream of or within several processes, including phagocytosis; positive regulation of tumor necrosis factor production; and regulation of calcineurin-NFAT signaling cascade. Located in external side of plasma membrane. Is expressed in several structures, including gut; limb; musculature; spleen; and ventral grey horn. Human ortholog(s) of this gene implicated in aspergillosis and chronic mucocutaneous candidiasis. Orthologous to human CLEC7A (C-type lectin domain containing 7A). [provided by Alliance of Genome Resources, Jul 2025]	6	129438554	129449748	Mouse	256	symbol , PhenoGen , description	gene, protein-coding, VALIDATED [RefSeq]
1565140	Clec7a	C-type lectin domain containing 7A	ENCODES a protein that exhibits (1->3)-beta-D-glucan binding (ortholog); (1->3)-beta-D-glucan immune receptor activity (ortholog); carbohydrate binding (ortholog); INVOLVED IN antifungal innate immune response (ortholog); apoptotic signaling pathway (ortholog); cell activation (ortholog); PARTICIPAT ... (more) ES IN phagocytosis pathway; tuberculosis pathway; ASSOCIATED WITH aspergillosis (ortholog); Candidiasis, Familial, 4 (ortholog); chronic mucocutaneous candidiasis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); external side of plasma membrane (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine	4	164588737	164599953	Rat	246	symbol , PhenoGen	gene, protein-coding, VALIDATED [RefSeq]
11744592	CLEC7A	C-type lectin domain containing 7A	ENCODES a protein that exhibits (1->3)-beta-D-glucan immune receptor activity (ortholog); identical protein binding (ortholog); opsonin binding (ortholog); INVOLVED IN antifungal innate immune response (ortholog); cell activation (ortholog); cell surface pattern recognition receptor signaling pathwa ... (more) y (ortholog); ASSOCIATED WITH aspergillosis (ortholog); Candidiasis, Familial, 4 (ortholog); chronic mucocutaneous candidiasis (ortholog); FOUND IN external side of plasma membrane (ortholog)	12	10161780	10174943	Bonobo	110	symbol	gene, protein-coding, MODEL [RefSeq]
12227914	CLEC7A	C-type lectin domain containing 7A	ENCODES a protein that exhibits (1->3)-beta-D-glucan immune receptor activity (ortholog); identical protein binding (ortholog); opsonin binding (ortholog); INVOLVED IN antifungal innate immune response (ortholog); cell activation (ortholog); cell surface pattern recognition receptor signaling pathwa ... (more) y (ortholog); ASSOCIATED WITH aspergillosis (ortholog); Candidiasis, Familial, 4 (ortholog); chronic mucocutaneous candidiasis (ortholog); FOUND IN external side of plasma membrane (ortholog)	27	35852685	35885673	Dog	91	symbol	gene, protein-coding, MODEL [RefSeq]
12726282	Clec7a	C-type lectin domain containing 7A	ENCODES a protein that exhibits (1->3)-beta-D-glucan immune receptor activity (ortholog); carbohydrate binding (ortholog); identical protein binding (ortholog); INVOLVED IN antifungal innate immune response (ortholog); apoptotic signaling pathway (ortholog); cell activation (ortholog); ASSOCIATED WI ... (more) TH aspergillosis (ortholog); Candidiasis, Familial, 4 (ortholog); chronic mucocutaneous candidiasis (ortholog); FOUND IN cytoplasm (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog)	NW_004936902	436224	446435	Squirrel	87	symbol	gene, protein-coding, MODEL [RefSeq]
18707802	CLEC7A	C-type lectin domain containing 7A	ENCODES a protein that exhibits (1->3)-beta-D-glucan immune receptor activity (ortholog); identical protein binding (ortholog); opsonin binding (ortholog); INVOLVED IN antifungal innate immune response (ortholog); cell activation (ortholog); cell surface pattern recognition receptor signaling pathwa ... (more) y (ortholog); ASSOCIATED WITH aspergillosis (ortholog); Candidiasis, Familial, 4 (ortholog); chronic mucocutaneous candidiasis (ortholog); FOUND IN external side of plasma membrane (ortholog)				Green Monkey	110	symbol	gene, protein-coding, MODEL [RefSeq]
39131543	CLEC7A	C-type lectin domain containing 7A					Chinchilla		symbol	gene, protein-coding
18919878	Clec7a	C-type lectin domain containing 7A	ENCODES a protein that exhibits (1->3)-beta-D-glucan immune receptor activity (ortholog); identical protein binding (ortholog); opsonin binding (ortholog); INVOLVED IN antifungal innate immune response (ortholog); apoptotic signaling pathway (ortholog); cell activation (ortholog); ASSOCIATED WITH as ... (more) pergillosis (ortholog); Candidiasis, Familial, 4 (ortholog); chronic mucocutaneous candidiasis (ortholog); FOUND IN cytoplasm (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog)				Naked Mole-Rat	88	symbol	gene, protein-coding, MODEL [RefSeq]
625914327	Clec7a	C-type lectin domain containing 7A	ENCODES a protein that exhibits (1->3)-beta-D-glucan binding (ortholog); (1->3)-beta-D-glucan immune receptor activity (ortholog); carbohydrate binding (ortholog); INVOLVED IN antifungal innate immune response (ortholog); apoptotic signaling pathway (ortholog); cell activation (ortholog); ASSOCIATED ... (more) WITH aspergillosis (ortholog); Candidiasis, Familial, 4 (ortholog); chronic mucocutaneous candidiasis (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); external side of plasma membrane (ortholog)				Black Rat	89	symbol	gene, protein-coding, MODEL [RefSeq]
14158521	CLEC7A	C-type lectin domain containing 7A	ENCODES a protein that exhibits (1->3)-beta-D-glucan immune receptor activity (ortholog); identical protein binding (ortholog); opsonin binding (ortholog); INVOLVED IN antifungal innate immune response (ortholog); cell activation (ortholog); cell surface pattern recognition receptor signaling pathwa ... (more) y (ortholog); ASSOCIATED WITH aspergillosis (ortholog); Candidiasis, Familial, 4 (ortholog); chronic mucocutaneous candidiasis (ortholog); FOUND IN external side of plasma membrane (ortholog)				Pig	91	symbol	gene, protein-coding, VALIDATED [RefSeq]
8838902	Clec1a	C-type lectin domain family 1 member A	INVOLVED IN cell recognition (ortholog); defense response to fungus (ortholog); immune response (ortholog); ASSOCIATED WITH aspergillosis (ortholog)	NW_004955413	7742753	7783299	Chinchilla	6	old_gene_symbol	gene, protein-coding, MODEL [RefSeq]