Clec7a (C-type lectin domain containing 7A) - Rat Genome Database

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Gene: Clec7a (C-type lectin domain containing 7A) Heterocephalus glaber
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Symbol: Clec7a
Name: C-type lectin domain containing 7A
RGD ID: 18919878
Description: ENCODES a protein that exhibits (1->3)-beta-D-glucan immune receptor activity (ortholog); identical protein binding (ortholog); opsonin binding (ortholog); INVOLVED IN antifungal innate immune response (ortholog); cell activation (ortholog); cell recognition (ortholog); ASSOCIATED WITH aspergillosis (ortholog); Candidiasis, Familial, 4 (ortholog); Fungal Keratitis (ortholog); FOUND IN cytoplasm (ortholog); external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C-type lectin domain family 7 member A
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475226,871,292 - 26,891,910 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475226,871,556 - 26,885,778 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antifungal innate immune response  (ISO)
cell activation  (ISO)
cell recognition  (ISO)
cell surface pattern recognition receptor signaling pathway  (ISO)
cell-cell adhesion  (ISO)
cellular response to molecule of fungal origin  (IEA)
detection of fungus  (IEA)
detection of molecule of fungal origin  (IEA)
detection of yeast  (ISO)
innate immune response  (ISO)
leukocyte activation involved in immune response  (ISO)
phagocytosis, engulfment  (ISO)
phagocytosis, recognition  (IEA,ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell maturation  (ISO)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of cytokine production involved in immune response  (ISO)
positive regulation of cytokine production involved in inflammatory response  (IEA)
positive regulation of dendritic cell cytokine production  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of interleukin-23 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of killing of cells of another organism  (IEA)
positive regulation of lymphocyte activation  (IEA)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of nitric oxide biosynthetic process  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phagocytosis  (IEA,ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of respiratory burst  (ISO)
positive regulation of stress-activated MAPK cascade  (ISO)
positive regulation of superoxide anion generation  (ISO)
positive regulation of T-helper 17 type immune response  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of wound healing  (IEA)
regulation of calcineurin-NFAT signaling cascade  (ISO)
regulation of canonical NF-kappaB signal transduction  (ISO)
response to molecule of fungal origin  (ISO)
response to yeast  (ISO)
stimulatory C-type lectin receptor signaling pathway  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Clec7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475226,871,292 - 26,891,910 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475226,871,556 - 26,885,778 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CLEC7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381210,116,777 - 10,130,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1210,116,777 - 10,130,258 (-)EnsemblGRCh38hg38GRCh38
GRCh371210,269,376 - 10,282,798 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361210,160,643 - 10,174,135 (-)NCBINCBI36Build 36hg18NCBI36
Build 341210,171,190 - 10,174,103NCBI
Celera1215,430,059 - 15,443,548 (-)NCBICelera
Cytogenetic Map12p13.2NCBI
HuRef1210,012,523 - 10,026,010 (-)NCBIHuRef
CHM1_11210,238,652 - 10,252,134 (-)NCBICHM1_1
T2T-CHM13v2.01210,003,452 - 10,016,972 (-)NCBIT2T-CHM13v2.0
Clec7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396129,438,554 - 129,449,748 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6129,438,554 - 129,449,742 (-)EnsemblGRCm39 Ensembl
GRCm386129,461,591 - 129,472,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6129,461,591 - 129,472,779 (-)EnsemblGRCm38mm10GRCm38
MGSCv376129,411,609 - 129,422,795 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366129,427,284 - 129,438,465 (-)NCBIMGSCv36mm8
Celera6131,183,577 - 131,194,776 (-)NCBICelera
Cytogenetic Map6F3NCBI
cM Map663.34NCBI
Clec7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84164,588,737 - 164,599,953 (-)NCBIGRCr8
mRatBN7.24162,902,731 - 162,913,931 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4162,902,732 - 162,913,897 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4169,137,545 - 169,148,615 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04164,920,504 - 164,931,574 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04163,554,549 - 163,565,619 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04163,216,152 - 163,227,367 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4163,216,163 - 163,227,334 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04211,859,714 - 211,870,889 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44166,723,515 - 166,734,681 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4151,587,575 - 151,598,651 (-)NCBICelera
Cytogenetic Map4q42NCBI
CLEC7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21015,604,637 - 15,617,580 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11215,599,522 - 15,614,341 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01210,161,780 - 10,174,943 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11210,410,384 - 10,425,452 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1210,410,384 - 10,425,452 (-)Ensemblpanpan1.1panPan2
CLEC7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12735,852,685 - 35,885,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2735,853,099 - 36,007,157 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2710,738,120 - 10,766,549 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02736,203,142 - 36,231,601 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2736,209,883 - 36,264,356 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12736,091,248 - 36,119,494 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02736,120,431 - 36,141,974 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02710,260,084 - 10,288,263 (-)NCBIUU_Cfam_GSD_1.0
Clec7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494597,304,630 - 97,315,165 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936902436,224 - 446,435 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLEC7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl561,832,954 - 61,846,434 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1561,832,910 - 61,846,441 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2564,542,875 - 64,556,425 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CLEC7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1119,989,520 - 10,007,442 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl119,995,203 - 10,006,746 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660892,066,063 - 2,084,594 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


RefSeq Acc Id: ENSHGLT00000013415   ⟹   ENSHGLP00000013276
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462475226,871,292 - 26,891,910 (-)Ensembl
RefSeq Acc Id: XM_004845883   ⟹   XP_004845940
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475226,871,556 - 26,885,778 (-)NCBI
RefSeq Acc Id: XM_004845884   ⟹   XP_004845941
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462475226,871,556 - 26,885,778 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004845940 (Get FASTA)   NCBI Sequence Viewer  
  XP_004845941 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000013276
RefSeq Acc Id: XP_004845941   ⟸   XM_004845884
- Peptide Label: isoform X2
- UniProtKB: G5BDZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004845940   ⟸   XM_004845883
- Peptide Label: isoform X1
- UniProtKB: G5BDZ6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSHGLP00000013276   ⟸   ENSHGLT00000013415


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000009485 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000013415 ENTREZGENE
Gene3D-CATH Mannose-Binding Protein A, subunit A UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/TrEMBL
  CLEC7A UniProtKB/TrEMBL
  CTDL_fold UniProtKB/TrEMBL
  NKR-like_CTLD UniProtKB/TrEMBL
NCBI Gene Clec7a ENTREZGENE
PANTHER C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A UniProtKB/TrEMBL
  C-TYPE LECTIN DOMAIN FAMILY 7 MEMBER A UniProtKB/TrEMBL
Pfam Lectin_C UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_2 UniProtKB/TrEMBL
SMART CLECT UniProtKB/TrEMBL
Superfamily-SCOP C-type lectin-like UniProtKB/TrEMBL
UniProt G5BDZ6 ENTREZGENE, UniProtKB/TrEMBL