| 2351 | Chrnb4 | cholinergic receptor nicotinic beta 4 subunit | ENCODES a protein that exhibits acetylcholine binding; heterocyclic compound binding; protein-containing complex binding; INVOLVED IN membrane depolarization; acetylcholine receptor signaling pathway (ortholog); action potential (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotin ic acetylcholine receptor; ASSOCIATED WITH depressive disorder; Transplant Rejection; amyotrophic lateral sclerosis (ortholog); FOUND IN acetylcholine-gated channel complex; plasma membrane; protein-containing complex; INTERACTS WITH (S)-anabasine; (S)-nicotine; 17beta-estradiol | 8 | 64312644 | 64333319 | Rat | 208 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732764 | CHRNB4 | cholinergic receptor nicotinic beta 4 subunit | This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homo meric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017] | 15 | 78624111 | 78661641 | Human | 226 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 732765 | Chrnb4 | cholinergic receptor, nicotinic, beta polypeptide 4 | Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in positive regulation of transmission of nerve impulse. Acts upstream of or within several processes, including behavioral response to nicotine; neuronal action potential; a nd synaptic transmission involved in micturition. Is active in cholinergic synapse and postsynaptic specialization membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and thymus. Human ortholog(s) of this gene implicated in cocaine abuse; lung cancer (multiple); nicotine dependence; and oral cavity cancer. Orthologous to human CHRNB4 (cholinergic receptor nicotinic beta 4 subunit). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 54935438 | 54956236 | Mouse | 239 | symbol , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8780799 | Chrnb4 | cholinergic receptor nicotinic beta 4 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); action potential (ortholog); behavioral response to nicotine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); chronic obstructive pulmonary disease (ortholog); cocaine abuse (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cell junction (ortholog); cholinergic synapse (ortholog) | NW_004955450 | 1013897 | 1030232 | Chinchilla | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12003312 | CHRNB4 | cholinergic receptor nicotinic beta 4 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN action potential (ortholog); behavioral response to nicotine (ortholog); locomotory behavior (ortholog) ; PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); chronic obstructive pulmonary disease (ortholog); cocaine abuse (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); plasma membrane (ortholog) | 15 | 57552697 | 57570828 | Bonobo | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12263516 | CHRNB4 | cholinergic receptor nicotinic beta 4 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN action potential (ortholog); behavioral response to nicotine (ortholog); locomotory behavior (ortholog) ; PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); chronic obstructive pulmonary disease (ortholog); cocaine abuse (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cell junction (ortholog); protein-containing complex (ortholog) | 13 | 38312537 | 38327242 | Dog | 74 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12690720 | Chrnb4 | cholinergic receptor nicotinic beta 4 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN action potential (ortholog); behavioral response to nicotine (ortholog); locomotory behavior (ortholog) ; PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); chronic obstructive pulmonary disease (ortholog); cocaine abuse (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); protein-containing complex (ortholog) | NW_004936471 | 36408471 | 36425571 | Squirrel | 73 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18902851 | Chrnb4 | cholinergic receptor nicotinic beta 4 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); action potential (ortholog); behavioral response to nicotine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); chronic obstructive pulmonary disease (ortholog); cocaine abuse (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cell junction (ortholog); cholinergic synapse (ortholog) | | | | Naked Mole-Rat | 75 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625878506 | Chrnb4 | cholinergic receptor nicotinic beta 4 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); action potential (ortholog); behavioral response to nicotine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); chronic obstructive pulmonary disease (ortholog); cocaine abuse (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cell junction (ortholog); cholinergic synapse (ortholog) | | | | Black Rat | 63 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 288083305 | chrnb4 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14237916 | CHRNB4 | cholinergic receptor nicotinic beta 4 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); action potential (ortholog); behavioral response to nicotine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); chronic obstructive pulmonary disease (ortholog); cocaine abuse (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cell junction (ortholog); cholinergic synapse (ortholog) | | | | Pig | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18492883 | CHRNB4 | cholinergic receptor nicotinic beta 4 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); heterocyclic compound binding (ortholog); INVOLVED IN action potential (ortholog); behavioral response to nicotine (ortholog); locomotory behavior (ortholog) ; PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); chronic obstructive pulmonary disease (ortholog); cocaine abuse (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); plasma membrane (ortholog) | | | | Green Monkey | 77 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284120361 | chrnb4.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 329329206 | chrnb4.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 13207489 | Chrnb4em5Mcwi | cholinergic receptor nicotinic beta 4 subunit;CRISPR/Cas9 system induced mutant 5, Mcwi | CRISPR/Cas9 system was used to introduce a mutation in the Chrnb4 gene of LEW/Crl rat embryos. The resulting mutation is a 4-bp deletion of exon 4 in the Chrnb4 gene. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 16562273 | AC067863.1 | novel transcript, antisense to CHRNB4 | | | | | Human | | name | gene, lncrna |
| 16563336 | AC091304.4 | cholinergic receptor, nicotinic, beta 4 (CHRNB4) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |
| 16562751 | AC138749.2 | cholinergic receptor, nicotinic, beta 4 (CHRNB4) pseudogene | | | | | Human | | name | gene, unprocessed_pseudogene |