| 2345 | Chrna3 | cholinergic receptor nicotinic alpha 3 subunit | ENCODES a protein that exhibits acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated monoatomic cation-selective channel activity; INVOLVED IN acetylcholine receptor signaling pathway; heart development; membrane depolarization; PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH Carbon Monoxide Poisoning; depressive disorder; Experimental Seizures; FOUND IN acetylcholine-gated channel complex; cholinergic synapse; dendrite; INTERACTS WITH (S)-anabasine; (S)-nicotine; 1,1-dimethyl-4-phenylpiperazinium iodide | 8 | 64297755 | 64311251 | Rat | 297 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 732613 | CHRNA3 | cholinergic receptor nicotinic alpha 3 subunit | This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The enco ded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009] | 15 | 78593052 | 78620996 | Human | 319 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 732614 | Chrna3 | cholinergic receptor, nicotinic, alpha polypeptide 3 | Enables acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within several processes, including activation of transmembrane receptor protein tyrosine kinase activity; behavioral response to nicotine; and chemical synaptic transmission. Part of acetylcholine-gated ch annel complex. Is active in cholinergic synapse and postsynaptic specialization membrane. Is expressed in several structures, including central nervous system; gut; myenteric nerve plexus; paravertebral ganglion; and retina. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; chronic obstructive pulmonary disease; cocaine dependence; lung cancer (multiple); and nicotine dependence. Orthologous to human CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 54917401 | 54933846 | Mouse | 325 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8919698 | Chrna3 | cholinergic receptor nicotinic alpha 3 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); activation of transmembrane receptor protein tyr osine kinase activity (ortholog); behavioral response to nicotine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog) | NW_004955450 | 979630 | 1011316 | Chinchilla | 105 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11903599 | CHRNA3 | cholinergic receptor nicotinic alpha 3 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN activation of transmembrane receptor protein tyrosine kinase activity (ortholog); behavioral response to nicotine (ortholog); excitatory postsynaptic potential (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog) | 15 | 57523553 | 57550228 | Bonobo | 118 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12204015 | CHRNA3 | cholinergic receptor nicotinic alpha 3 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN activation of transmembrane receptor protein tyrosine kinase activity (ortholog); behavioral response to nicotine (ortholog); excitatory postsynaptic potential (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog) | 13 | 38330287 | 38343142 | Dog | 120 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12664954 | Chrna3 | cholinergic receptor nicotinic alpha 3 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN activation of transmembrane receptor protein tyrosine kinase activity (ortholog); behavioral response to nicotine (ortholog); excitatory postsynaptic potential (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog) | NW_004936471 | 36427598 | 36447903 | Squirrel | 115 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626158851 | Chrna3 | cholinergic receptor nicotinic alpha 3 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); activation of transmembrane receptor protein tyr osine kinase activity (ortholog); behavioral response to nicotine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog) | | | | Black Rat | 105 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18461352 | CHRNA3 | cholinergic receptor nicotinic alpha 3 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN activation of transmembrane receptor protein tyrosine kinase activity (ortholog); behavioral response to nicotine (ortholog); excitatory postsynaptic potential (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog) | | | | Green Monkey | 117 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13855889 | CHRNA3 | cholinergic receptor nicotinic alpha 3 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN activation of transmembrane receptor protein tyrosine kinase activity (ortholog); behavioral response to nicotine (ortholog); excitatory postsynaptic potential (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog); INTERACTS WITH (S)-nicotine; carbon dioxide; dioxygen | | | | Pig | 130 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18900935 | Chrna3 | cholinergic receptor nicotinic alpha 3 subunit | ENCODES a protein that exhibits acetylcholine binding (ortholog); acetylcholine receptor activity (ortholog); acetylcholine-gated monoatomic cation-selective channel activity (ortholog); INVOLVED IN acetylcholine receptor signaling pathway (ortholog); activation of transmembrane receptor protein tyr osine kinase activity (ortholog); behavioral response to nicotine (ortholog); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN acetylcholine-gated channel complex (ortholog); cholinergic synapse (ortholog); dendrite (ortholog) | | | | Naked Mole-Rat | 116 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 10054371 | Chrna3em1Mcwi | cholinergic receptor, nicotinic, alpha 3 (neuronal); CRISPR/Cas9 system induced mutant 1, Medical College of Wisconsin | This allele was made by CRISPR/Cas9 system. The resulting mutation is a 1-bp (G) insertion in the Chrna3 gene;(RGSC 5.0/rn5) chr8:58,186,969-58,186,970 | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 10054374 | Chrna3em9Mcwi | cholinergic receptor, nicotinic, alpha 3 (neuronal); CRISPR/Cas9 system induced mutant 9, Medical College of Wisconsin | This allele was made by CRISPR/Cas9 system. The resulting mutation is a 17-bp deletion in the Chrna3 gene. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 626178475 | chrna3l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626179011 | chrna3l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626181329 | chrna3l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626185611 | chrna3l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626175843 | chrna3l | | | | | | Tropical Clawed Frog | | symbol | gene, null |