| 620122 | Chl1 | cell adhesion molecule L1-like | ENCODES a protein that exhibits identical protein binding (ortholog); protease binding (ortholog); INVOLVED IN axon regeneration; adult locomotory behavior (ortholog); axon guidance (ortholog); ASSOCIATED WITH Peripheral Nerve Injuries; Spinal Cord Injuries; epilepsy (ortholog); FOUND IN apical part of cell (ortholog); dendrite (ortholog); INTERACTS WITH 4,4'-sulfonyldiphenol; bisphenol A; bisphenol F | 4 | 137847648 | 138062077 | Rat | 104 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1346370 | CHL1 | cell adhesion molecule L1 like | The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. T his protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011] | 3 | 196763 | 409417 | Human | 101 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1616869 | Chl1 | cell adhesion molecule L1-like | Enables protease binding activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including adult locomotory behavior; exploration behavior; and generation of neurons. Located in apical part of cell and dendrite. Is expressed in head mesenc hyme; nervous system; and retina. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CHL1 (cell adhesion molecule L1 like). [provided by Alliance of Genome Resources, Jul 2025] | 6 | 103487372 | 103709999 | Mouse | 114 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8951818 | Chl1 | cell adhesion molecule L1 like | ENCODES a protein that exhibits identical protein binding (ortholog); protease binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); axon guidance (ortholog); axon regeneration (ortholog); ASSOCIATED WITH epilepsy (ortholog); intellectual disability (ortholog); Peripheral Nerve Injur ies (ortholog); FOUND IN apical part of cell (ortholog); dendrite (ortholog) | NW_004955421 | 12763432 | 12957852 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11987876 | CHL1 | cell adhesion molecule L1 like | ENCODES a protein that exhibits protease binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); axon guidance (ortholog); axon regeneration (ortholog); ASSOCIATED WITH epilepsy (ortholog); intellectual disability (ortholog); Peripheral Nerve Injuries (ortholog); FOUND IN apical part o f cell (ortholog); dendrite (ortholog) | 3 | 146514 | 354334 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12426595 | CHL1 | cell adhesion molecule L1 like | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); axon guidance (ortholog); axon regeneration (ortholog); ASSOCIATED WITH epilepsy (ortholog); intellectual disability (ortholog); Peripheral Nerve Injuries (ortholog); FOUND IN apic al part of cell (inferred); dendrite (inferred); membrane (inferred) | 20 | 16789697 | 17065861 | Dog | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12695889 | Chl1 | cell adhesion molecule L1 like | ENCODES a protein that exhibits cell-cell adhesion mediator activity (inferred); identical protein binding (inferred); protease binding (inferred); INVOLVED IN adult locomotory behavior (ortholog); axon guidance (ortholog); axon regeneration (ortholog); ASSOCIATED WITH epilepsy (ortholog); intellect ual disability (ortholog); Peripheral Nerve Injuries (ortholog); FOUND IN apical part of cell (inferred); axon (inferred); dendrite (inferred) | NW_004936577 | 471766 | 547769 | Squirrel | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18647273 | CHL1 | cell adhesion molecule L1 like | ENCODES a protein that exhibits identical protein binding (inferred); protease binding (inferred); INVOLVED IN adult locomotory behavior (ortholog); axon guidance (ortholog); axon regeneration (ortholog); ASSOCIATED WITH epilepsy (ortholog); intellectual disability (ortholog); Peripheral Nerve Injur ies (ortholog); FOUND IN apical part of cell (inferred); dendrite (inferred); membrane (inferred) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13976992 | CHL1 | cell adhesion molecule L1 like | ENCODES a protein that exhibits identical protein binding (inferred); protease binding (inferred); INVOLVED IN adult locomotory behavior (ortholog); axon guidance (ortholog); axon regeneration (ortholog); ASSOCIATED WITH epilepsy (ortholog); intellectual disability (ortholog); Peripheral Nerve Injur ies (ortholog); FOUND IN apical part of cell (inferred); dendrite (inferred); membrane (inferred); INTERACTS WITH deoxynivalenol | | | | Pig | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18909426 | Chl1 | cell adhesion molecule L1 like | ENCODES a protein that exhibits identical protein binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); axon guidance (ortholog); axon regeneration (ortholog); ASSOCIATED WITH epilepsy (ortholog); intellectual disability (ortholog); Peripheral Nerve Injuries (ortholog); FOUND IN apic al part of cell (inferred); axon (inferred); dendrite (inferred) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625954673 | Chl1 | cell adhesion molecule L1 like | ENCODES a protein that exhibits identical protein binding (ortholog); protease binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); axon guidance (ortholog); axon regeneration (ortholog); ASSOCIATED WITH epilepsy (ortholog); intellectual disability (ortholog); Peripheral Nerve Injur ies (ortholog); FOUND IN apical part of cell (ortholog); dendrite (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14372874 | CHL1 | | | | | | Yeast | | symbol | gene, null |
| 8552135 | CHL1-AS1 | CHL1 antisense RNA 1 | | 3 | 363373 | 385795 | Human | | symbol , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 5144382 | CHL1-AS2 | CHL1 antisense RNA 2 | INTERACTS WITH dorsomorphin; phenylmercury acetate; SB 431542 | 3 | 195758 | 197341 | Human | 6 | symbol , old_gene_name , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 1553872 | Chrdl1 | chordin-like 1 | Enables BMP binding activity and transforming growth factor beta binding activity. Involved in several processes, including BMP signaling pathway; excitatory chemical synaptic transmission; and synapse organization. Is active in extracellular region. Is expressed in several structures, including ali mentary system; embryo mesenchyme; genitourinary system; neural ectoderm; and skeletal system. Human ortholog(s) of this gene implicated in megalocornea. Orthologous to human CHRDL1 (chordin like 1). [provided by Alliance of Genome Resources, Jul 2025] | X | 142068670 | 142177282 | Mouse | 155 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1315426 | DDX11 | DEAD/H-box helicase 11 | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splic eosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] | 12 | 31073860 | 31104799 | Human | 183 | old_gene_name , description , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1550550 | Ddx11 | DEAD/H box helicase 11 | Predicted to enable several functions, including 5'-3' DNA helicase activity; DNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in several processes, including cellular response to bleomycin; cellular response to cisplatin; and positive regulation of nucleobase -containing compound metabolic process. Predicted to be located in several cellular components, including extracellular exosome; microtubule cytoskeleton; and nuclear lumen. Predicted to be part of Ctf18 RFC-like complex. Predicted to be active in nucleus. Is expressed in several structures, including cerebral cortex; extraembryonic component; and placenta. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Orthologous to several human genes including DDX11 (DEAD/H-box helicase 11). [provided by Alliance of Genome Resources, Apr 2025] | 17 | 66430508 | 66459169 | Mouse | 213 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1353174 | DDX24 | DEAD-box helicase 24 | DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splic eosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. [provided by RefSeq, Jul 2008] | 14 | 94048287 | 94081202 | Human | 107 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 1352632 | DDX12P | DEAD/H-box helicase 12, pseudogene | Predicted to enable DNA helicase activity. Predicted to be involved in establishment of sister chromatid cohesion. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] | 12 | 9417691 | 9448172 | Human | 31 | old_gene_name | gene, pseudo, VALIDATED [RefSeq] |
| 1306675 | Ddx11 | DEAD/H-box helicase 11 | ENCODES a protein that exhibits 5'-3' DNA helicase activity (ortholog); ATP-dependent activity, acting on DNA (ortholog); ATP-dependent activity, acting on RNA (ortholog); INVOLVED IN cellular response to bleomycin (ortholog); cellular response to cisplatin (ortholog); cellular response to hydroxyur ea (ortholog); ASSOCIATED WITH Chromosome Breakage (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN centrosome (ortholog); chromatin (ortholog); midbody (ortholog); INTERACTS WITH amphetamine; bisphenol A; C60 fullerene | 9 | 113204886 | 113309692 | Rat | 116 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 12079017 | DDX11 | DEAD/H-box helicase 11 | ENCODES a protein that exhibits 5'-3' DNA helicase activity (ortholog); ATP-dependent activity, acting on DNA (ortholog); ATP-dependent activity, acting on RNA (ortholog); INVOLVED IN cellular response to bleomycin (ortholog); cellular response to cisplatin (ortholog); cellular response to hydroxyur ea (ortholog); ASSOCIATED WITH Chromosome Breakage (ortholog); genetic disease (ortholog); microcephaly (ortholog); FOUND IN centrosome (ortholog); chromatin (ortholog); midbody (ortholog) | 27 | 42067845 | 42102699 | Dog | 61 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 1321395 | CHTF18 | chromosome transmission fidelity factor 18 | This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex th at plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016] | 16 | 788620 | 798074 | Human | 130 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1321396 | Chtf18 | CTF18, chromosome transmission fidelity factor 18 | Predicted to enable DNA binding activity. Predicted to contribute to DNA clamp loader activity and single-stranded DNA helicase activity. Acts upstream of or within germ cell development; meiotic nuclear division; and negative regulation of chromosome segregation. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and integumental system. Orthologous to human CHTF18 (chromosome transmission fidelity factor 18). [provided by Alliance of Genome Resources, Jul 2025] | 17 | 25938004 | 25946409 | Mouse | 147 | old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
