| 621233 | Cdx1 | caudal type homeo box 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); methyl-CpG binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); bone morphogenesis (ortholog); pa ttern specification process (ortholog); FOUND IN nucleus (inferred); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; all-trans-retinoic acid | 18 | 56742970 | 56761299 | Rat | 99 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1321203 | CDX1 | caudal type homeobox 1 | This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-cat enin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008] | 5 | 150166778 | 150184558 | Human | 97 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1321204 | Cdx1 | caudal type homeobox 1 | Enables DNA-binding transcription factor activity. Involved in regulation of somitogenesis. Acts upstream of or within anterior/posterior pattern specification; bone morphogenesis; and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in sever al structures, including early conceptus; embryo ectoderm; embryo mesenchyme; genitourinary system; and intestine. Orthologous to human CDX1 (caudal type homeobox 1). [provided by Alliance of Genome Resources, Jul 2025] | 18 | 61151934 | 61169292 | Mouse | 130 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8838413 | Cdx1 | caudal type homeobox 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); methyl-CpG binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); bone morphogenesis (ortholog); pa ttern specification process (ortholog) | NW_004955415 | 4337903 | 4355782 | Chinchilla | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11996312 | CDX1 | caudal type homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); bone morphogenesis (ortholog); pattern s pecification process (ortholog); FOUND IN nucleus (inferred) | 5 | 145591186 | 145608976 | Bonobo | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12305581 | CDX1 | caudal type homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); bone morphogenesis (ortholog); pattern s pecification process (ortholog); FOUND IN nucleus (inferred) | 4 | 58897914 | 58915573 | Dog | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12554800 | Cdx1 | caudal type homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); bone morphogenesis (ortholog); pattern s pecification process (ortholog); FOUND IN nucleus (inferred) | NW_004936504 | 4736621 | 4752354 | Squirrel | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14027424 | CDX1 | caudal type homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); bone morphogenesis (ortholog); pattern s pecification process (ortholog); FOUND IN nucleus (inferred) | | | | Pig | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235341 | cdx1 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18656473 | CDX1 | caudal type homeobox 1 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); bone morphogenesis (ortholog); pattern s pecification process (ortholog); FOUND IN nucleus (inferred) | | | | Green Monkey | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927243 | Cdx1 | caudal type homeobox 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); methyl-CpG binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); bone morphogenesis (ortholog); pattern specification process (ortholog); FOUND IN nucleus (inferred) | | | | Naked Mole-Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626095724 | Cdx1 | caudal type homeobox 1 | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); methyl-CpG binding (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); bone morphogenesis (ortholog); pa ttern specification process (ortholog) | | | | Black Rat | 17 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235342 | cdx1.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258292 | cdx1.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1349444 | HLA-A | major histocompatibility complex, class I, A | HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen so that they can be recognized by cytotoxic T cells. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. More than 6000 HLA-A alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020] | 6 | 29942532 | 29945870 | Human | 300 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1352836 | HLA-B | major histocompatibility complex, class I, B | HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008] | 6 | 31353875 | 31357179 | Human | 573 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
| 1353823 | HLA-E | major histocompatibility complex, class I, E | HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other cla ss I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq, Jul 2008] | 6 | 30489509 | 30494194 | Human | 237 | GenBank Protein | gene, protein-coding, REVIEWED [RefSeq] |
