| 1311875 | Cdc25c | cell division cycle 25C | ENCODES a protein that exhibits protein kinase binding (ortholog); protein serine/threonine kinase binding (ortholog); WW domain binding (ortholog); INVOLVED IN spermatogenesis; G2/M transition of mitotic cell cycle (ortholog); PARTICIPATES IN cell cycle pathway, mitotic; ASSOCIATED WITH breast canc er (ortholog); cervical cancer (ortholog); endometrial cancer (ortholog); FOUND IN perinuclear region of cytoplasm; cytoplasm (ortholog); mitochondrial intermembrane space (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; acetamide | 18 | 26608483 | 26630292 | Rat | 324 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1323559 | CDC25C | cell division cycle 25C | This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of th is gene have been described. [provided by RefSeq, Dec 2015] | 5 | 138285265 | 138338355 | Human | 344 | symbol , old_gene_name , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323560 | Cdc25c | cell division cycle 25C | This gene encodes a dual specificity phosphatase that dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis. [provided by RefSeq, Dec 2014] | 18 | 34866046 | 34884644 | Mouse | 350 | symbol , old_gene_name , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 10392057 | Cdc25c | cell division cycle 25C | ENCODES a protein that exhibits protein kinase binding (ortholog); protein serine/threonine kinase binding (ortholog); WW domain binding (ortholog); INVOLVED IN G2/M transition of mitotic cell cycle (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH breast cancer (ortholog); cervical cancer (or tholog); endometrial cancer (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial intermembrane space (ortholog); nuclear speck (ortholog) | NW_004955418 | 2114053 | 2138513 | Chinchilla | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12044481 | CDC25C | cell division cycle 25C | ENCODES a protein that exhibits hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); protein kinase binding (inferred); INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH breast cancer (ortholog); cervical cancer (ortholog); endometrial cancer (ortholog); FOUND IN peri nuclear region of cytoplasm (ortholog) | 5 | 133663210 | 133717974 | Bonobo | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12087993 | CDC25C | cell division cycle 25C | ENCODES a protein that exhibits hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); protein kinase binding (inferred); INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH breast cancer (ortholog); cervical cancer (ortholog); endometrial cancer (ortholog); FOUND IN peri nuclear region of cytoplasm (ortholog) | 11 | 25904152 | 25940754 | Dog | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12679803 | Cdc25c | cell division cycle 25C | ENCODES a protein that exhibits hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); protein kinase binding (inferred); INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH breast cancer (ortholog); cervical cancer (ortholog); endometrial cancer (ortholog); FOUND IN peri nuclear region of cytoplasm (ortholog) | NW_004936531 | 7471722 | 7499781 | Squirrel | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155234772 | cdc25c | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18920410 | Cdc25c | cell division cycle 25C | ENCODES a protein that exhibits protein kinase binding (ortholog); protein serine/threonine kinase binding (ortholog); WW domain binding (ortholog); INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH breast cancer (ortholog); cervical cancer (ortholog); endometrial cancer (ortholog); FOUND IN m itochondrial intermembrane space (ortholog); nuclear speck (ortholog); perinuclear region of cytoplasm (ortholog) | | | | Naked Mole-Rat | 43 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18608297 | CDC25C | cell division cycle 25C | ENCODES a protein that exhibits hydrolase activity (inferred); phosphoprotein phosphatase activity (inferred); protein kinase binding (inferred); INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH breast cancer (ortholog); cervical cancer (ortholog); endometrial cancer (ortholog); FOUND IN peri nuclear region of cytoplasm (ortholog) | | | | Green Monkey | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625953245 | Cdc25c | cell division cycle 25C | ENCODES a protein that exhibits protein kinase binding (ortholog); protein serine/threonine kinase binding (ortholog); WW domain binding (ortholog); INVOLVED IN G2/M transition of mitotic cell cycle (ortholog); spermatogenesis (ortholog); ASSOCIATED WITH breast cancer (ortholog); cervical cancer (or tholog); endometrial cancer (ortholog); FOUND IN cytoplasm (ortholog); mitochondrial intermembrane space (ortholog); nuclear speck (ortholog) | | | | Black Rat | 32 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14193049 | CDC25C | cell division cycle 25C | ENCODES a protein that exhibits axon guidance receptor activity (inferred); glial cell-derived neurotrophic factor receptor activity (inferred); hydrolase activity (inferred); INVOLVED IN spermatogenesis (ortholog); ASSOCIATED WITH breast cancer (ortholog); cervical cancer (ortholog); endometrial ca ncer (ortholog); FOUND IN nucleus (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH caffeine; deoxynivalenol | | | | Pig | 69 | symbol , old_gene_name | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155251353 | cdc25c.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244023 | cdc25c.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 284614215 | XB5832479 [provisional:cdc25c] | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 288083246 | XB5832479.L [provisional:cdc25c] | | | | | | African Clawed Frog | | symbol | gene, null |
| 287261546 | XB5832479.S [provisional:cdc25c] | | | | | | African Clawed Frog | | symbol | gene, null |
| 1353156 | MARK3 | microtubule affinity regulating kinase 3 | The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] | 14 | 103385415 | 103503831 | Human | 159 | old_gene_name | gene, protein-coding, REVIEWED [RefSeq] |
| 732861 | CHEK2 | checkpoint kinase 2 | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] | 22 | 28687742 | 28741834 | Human | 3000 | description | gene, protein-coding, REVIEWED [RefSeq] |
