| 1344323 | BRCC3 | BRCA1/BRCA2-containing complex subunit 3 | This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011] | X | 155071508 | 155123077 | Human | 194 | symbol , old_gene_name , COSMIC , Human Proteome Map , old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 1557359 | Brcc3 | BRCA1/BRCA2-containing complex, subunit 3 | Enables metal-dependent deubiquitinase activity. Involved in chromatin remodeling; positive regulation of NLRP3 inflammasome complex assembly; and protein K63-linked deubiquitination. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nu clear ubiquitin ligase complex. Is expressed in central nervous system and genitourinary system. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3). [provided by Alliance of Genome Resources, Jul 2025] | X | 74460234 | 74499307 | Mouse | 166 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1588543 | Brcc3 | BRCA1/BRCA2-containing complex subunit 3 | ENCODES a protein that exhibits enzyme regulator activity (ortholog); K63-linked deubiquitinase activity (ortholog); metal-dependent deubiquitinase activity (ortholog); INVOLVED IN cellular response to ionizing radiation (ortholog); chromatin remodeling (ortholog); DNA repair-dependent chromatin rem odeling (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Occupational Diseases (ortholog); Pregnancy in Diabetics (ortholog); FOUND IN BRCA1-A complex (ortholog); BRISC complex (ortholog); cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; acetamide | 9 | 2073927 | 2076469 | Rat | 152 | symbol , old_gene_name , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 8961613 | Brcc3 | BRCA1/BRCA2-containing complex subunit 3 | ENCODES a protein that exhibits enzyme regulator activity (ortholog); K63-linked deubiquitinase activity (ortholog); metal-dependent deubiquitinase activity (ortholog); INVOLVED IN cellular response to ionizing radiation (ortholog); chromatin remodeling (ortholog); DNA repair-dependent chromatin rem odeling (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Occupational Diseases (ortholog); Pregnancy in Diabetics (ortholog); FOUND IN BRCA1-A complex (ortholog); BRISC complex (ortholog); cytoplasm (ortholog) | NW_004955594 | 551407 | 613772 | Chinchilla | 45 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 11884338 | BRCC3 | BRCA1/BRCA2-containing complex subunit 3 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); enzyme regulator activity (inferred); hydrolase activity (inferred); INVOLVED IN chromatin remodeling (ortholog); response to X-ray (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; his tone modification pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Occupational Diseases (ortholog); Pregnancy in Diabetics (ortholog); FOUND IN BRCA1-A complex (inferred); BRISC complex (inferred); cytoplasm (inferred) | X | 144550320 | 144592795 | Bonobo | 73 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12315070 | BRCC3 | BRCA1/BRCA2-containing complex subunit 3 | ENCODES a protein that exhibits enzyme regulator activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN cellular response to ionizing radiation (ortholog); chromatin remodeling (ortholog); DNA repair-dependent chromatin remodeling (ortholog); PARTICIPATES IN ataxia telangiec tasia-mutated (ATM) signaling pathway; histone modification pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Occupational Diseases (ortholog); Pregnancy in Diabetics (ortholog); FOUND IN nuclear ubiquitin ligase complex (ortholog); nucleoplasm (ortholog); ubiquitin ligase complex (ortholog) | X | 123081262 | 123143509 | Dog | 66 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 12618507 | Brcc3 | BRCA1/BRCA2-containing complex subunit 3 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); enzyme regulator activity (inferred); hydrolase activity (inferred); INVOLVED IN chromatin remodeling (ortholog); response to X-ray (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; his tone modification pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Occupational Diseases (ortholog); Pregnancy in Diabetics (ortholog); FOUND IN BRCA1-A complex (inferred); BRISC complex (inferred); cytoplasm (inferred) | NW_004936927 | 341114 | 380817 | Squirrel | 70 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 14150152 | BRCC3 | BRCA1/BRCA2-containing complex subunit 3 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); enzyme regulator activity (inferred); hydrolase activity (inferred); INVOLVED IN chromatin remodeling (ortholog); response to X-ray (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; his tone modification pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Occupational Diseases (ortholog); Pregnancy in Diabetics (ortholog); FOUND IN BRCA1-A complex (inferred); BRISC complex (inferred); cytoplasm (inferred) | | | | Pig | 75 | symbol , old_gene_name , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 18639141 | BRCC3 | BRCA1/BRCA2-containing complex subunit 3 | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); enzyme regulator activity (inferred); hydrolase activity (inferred); INVOLVED IN chromatin remodeling (ortholog); response to X-ray (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; his tone modification pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Occupational Diseases (ortholog); Pregnancy in Diabetics (ortholog); FOUND IN BRCA1-A complex (inferred); BRISC complex (inferred); cytoplasm (inferred) | | | | Green Monkey | 73 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 18929527 | Brcc3 | BRCA1/BRCA2-containing complex subunit 3 | ENCODES a protein that exhibits enzyme regulator activity (ortholog); K63-linked deubiquitinase activity (ortholog); INVOLVED IN cellular response to ionizing radiation (ortholog); chromatin remodeling (ortholog); DNA repair-dependent chromatin remodeling (ortholog); PARTICIPATES IN ataxia telangiec tasia-mutated (ATM) signaling pathway; histone modification pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Occupational Diseases (ortholog); Pregnancy in Diabetics (ortholog); FOUND IN nuclear ubiquitin ligase complex (ortholog); nucleoplasm (ortholog); ubiquitin ligase complex (ortholog) | | | | Naked Mole-Rat | 59 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155254233 | brcc3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625869236 | Brcc3 | BRCA1/BRCA2-containing complex subunit 3 | ENCODES a protein that exhibits enzyme regulator activity (ortholog); K63-linked deubiquitinase activity (ortholog); metal-dependent deubiquitinase activity (ortholog); INVOLVED IN cellular response to ionizing radiation (ortholog); chromatin remodeling (ortholog); DNA repair-dependent chromatin rem odeling (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; ASSOCIATED WITH Hereditary Neoplastic Syndromes (ortholog); Occupational Diseases (ortholog); Pregnancy in Diabetics (ortholog); FOUND IN BRCA1-A complex (ortholog); BRISC complex (ortholog); cytoplasm (ortholog) | | | | Black Rat | 44 | symbol , old_gene_name | gene, protein-coding, MODEL [RefSeq] |
| 155246940 | brcc3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 2321947 | Brcc3-ps2 | BRCA1/BRCA2-containing complex, subunit 3, pseudogene 2 | | 1 | 150175321 | 150298239 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 40939791 | Brcc3-ps3 | BRCA1/BRCA2-containing complex, subunit 3, pseudogene 3 | | 3 | 119274982 | 119292589 | Rat | | symbol , old_gene_name , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 2325104 | Brcc3-ps4 | BRCA1/BRCA2-containing complex, subunit 3, pseudogene 4 | | 15 | 46748056 | 46749132 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1584942 | Brcc3-ps5 | BRCA1/BRCA2-containing complex, subunit 3, pseudogene 5 | | 1 | 57752500 | 57753372 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1592028 | Brcc3-ps6 | BRCA1/BRCA2-containing complex, subunit 3, pseudogene 6 | | 2 | 159487271 | 159488642 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 7604961 | Brcc3-ps7 | BRCA1/BRCA2-containing complex, subunit 3, pseudogene 7 | | 18 | 136140 | 139788 | Rat | | symbol , PhenoGen | gene, pseudo, VALIDATED [RefSeq] |
| 1314052 | DEPDC1B | DEP domain containing 1B | Predicted to enable GTPase activator activity. Involved in cell migration and positive regulation of Wnt signaling pathway. [provided by Alliance of Genome Resources, Jul 2025] | 5 | 60596912 | 60700166 | Human | 126 | old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1621202 | Brcc3dc | BRCA1/BRCA2-containing complex, subunit 3, domain containing | Predicted to enable K63-linked deubiquitinase activity; metal-dependent deubiquitinase activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including DNA repair-dependent chromatin remodeling; mitotic G2 DNA damage checkpoint sig naling; and positive regulation of NLRP3 inflammasome complex assembly. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3). [provided by Alliance of Genome Resources, Apr 2025] | 10 | 108534905 | 108536021 | Mouse | 51 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9447173 | Brcc3dc | BRCA1/BRCA2-containing complex, subunit 3, domain containing | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN cell division (inferred); DNA repair (inferred); double-strand break repair (inferred); FOUND IN BRCA1-A complex (inferred); BRISC complex (infer red); cytoplasm (inferred) | 7 | 45901321 | 45903078 | Rat | 35 | symbol , old_gene_name , PhenoGen | gene, protein-coding, INFERRED [RefSeq] |
| 9681558 | BRCC3P1 | BRCA1/BRCA2-containing complex subunit 3 pseudogene 1 | | 5 | 176308055 | 176309210 | Human | | symbol , COSMIC , Human Proteome Map | gene, pseudo, INFERRED [RefSeq] |
| 12438148 | LOC101961342 | lys-63-specific deubiquitinase BRCC36-like | | NW_004936516 | 8371338 | 8372152 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 12562338 | LOC101974118 | lys-63-specific deubiquitinase BRCC36-like | | NW_004936610 | 2172306 | 2173173 | Squirrel | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |
| 8981706 | LOC102013154 | lys-63-specific deubiquitinase BRCC36-like | | NW_004955466 | 7752096 | 7926894 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 626140231 | LOC116892774 | lys-63-specific deubiquitinase BRCC36-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 626030283 | LOC116893344 | lys-63-specific deubiquitinase BRCC36-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 626159185 | LOC116894618 | lys-63-specific deubiquitinase BRCC36-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 626114499 | LOC116895463 | lys-63-specific deubiquitinase BRCC36-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 625938818 | LOC116900949 | lys-63-specific deubiquitinase BRCC36-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 625910143 | LOC116908820 | lys-63-specific deubiquitinase BRCC36-like | | | | | Black Rat | | name | gene, protein-coding, MODEL [RefSeq] |
| 626101257 | LOC116913995 | lys-63-specific deubiquitinase BRCC36-like | | | | | Black Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 329332464 | LOC129397851 | lys-63-specific deubiquitinase BRCC36-like | | | | | Bonobo | | name | gene, pseudo, MODEL [RefSeq] |
| 402078358 | LOC134484868 | lys-63-specific deubiquitinase BRCC36-like | | 1 | 57370324 | 57371196 | Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 12320901 | LOC610150 | lys-63-specific deubiquitinase BRCC36-like | ENCODES a protein that exhibits cysteine-type deubiquitinase activity (inferred); hydrolase activity (inferred); metal ion binding (inferred); INVOLVED IN cell division (inferred); DNA repair (inferred); double-strand break repair (inferred); FOUND IN BRCA1-A complex (inferred); BRISC complex (infer red); cytoplasm (inferred) | 32 | 24754628 | 24755868 | Dog | 35 | old_gene_name , name | gene, protein-coding, MODEL [RefSeq] |
| 18933621 | LOC101696656 | lys-63-specific deubiquitinase BRCC36 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18925610 | LOC101699964 | lys-63-specific deubiquitinase BRCC36 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18905102 | LOC101709522 | lys-63-specific deubiquitinase BRCC36 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 18922226 | LOC101717227 | lys-63-specific deubiquitinase BRCC36 pseudogene | | | | | Naked Mole-Rat | | name | gene, pseudo, MODEL [RefSeq] |
| 8951934 | LOC102026377 | lys-63-specific deubiquitinase BRCC36 pseudogene | | NW_004955402 | 24870737 | 24872641 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 8946755 | LOC102028011 | lys-63-specific deubiquitinase BRCC36 pseudogene | | NW_004955529 | 1582227 | 1583024 | Chinchilla | | name | gene, pseudo, MODEL [RefSeq] |
| 18661365 | LOC103245605 | lys-63-specific deubiquitinase BRCC36 pseudogene | | | | | Green Monkey | | old_gene_name , name | gene, pseudo, MODEL [RefSeq] |