Brcc3 (BRCA1/BRCA2-containing complex subunit 3)

Gene: Brcc3 (BRCA1/BRCA2-containing complex subunit 3) Chinchilla lanigera

Analyze

Symbol:

Brcc3

Name:

BRCA1/BRCA2-containing complex subunit 3

RGD ID:

8961613

Description:

ENCODES a protein that exhibits enzyme regulator activity (ortholog); K63-linked deubiquitinase activity (ortholog); metal-dependent deubiquitinase activity (ortholog); INVOLVED IN cellular response to ionizing radiation (ortholog); chromatin remodeling (ortholog); DNA repair-dependent chromatin remodeling (ortholog); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; histone modification pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); autistic disorder (ortholog); Barth syndrome (ortholog); FOUND IN BRCA1-A complex (ortholog); BRISC complex (ortholog); cytoplasm (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

BRCA1/BRCA2-containing complex, subunit 3; lys-63-specific deubiquitinase BRCC36

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955594	554,081 - 613,661 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955594	551,407 - 613,772 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

Barth syndrome (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

favism (ISO)

Hereditary Neoplastic Syndromes (ISO)

immunodeficiency 33 (ISO)

Occupational Diseases (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

Pregnancy in Diabetics (ISO)

Splenomegaly (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to ionizing radiation (ISO)

chromatin remodeling (ISO)

DNA repair-dependent chromatin remodeling (ISO)

double-strand break repair (ISO)

mitotic G2 DNA damage checkpoint signaling (ISO)

positive regulation of DNA repair (ISO)

positive regulation of NLRP3 inflammasome complex assembly (ISO)

response to ionizing radiation (ISO)

response to X-ray (ISO)

Cellular Component

BRCA1-A complex (ISO)

BRISC complex (ISO)

cytoplasm (ISO)

nuclear ubiquitin ligase complex (ISO)

nucleoplasm (ISO)

nucleus (ISO)

ubiquitin ligase complex (ISO)

Molecular Function

enzyme regulator activity (ISO)

K63-linked deubiquitinase activity (ISO)

metal-dependent deubiquitinase activity (ISO)

metallopeptidase activity (ISO)

polyubiquitin modification-dependent protein binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ataxia telangiectasia-mutated (ATM) signaling pathway (ISO)

histone modification pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Brcc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955594	554,081 - 613,661 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955594	551,407 - 613,772 (-)	NCBI	ChiLan1.0	ChiLan1.0

BRCC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	155,071,508 - 155,123,077 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	155,071,420 - 155,123,077 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	154,299,783 - 154,351,352 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	153,952,904 - 154,004,543 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	153,863,504 - 153,915,052	NCBI
Celera	X	154,458,427 - 154,510,104 (+)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	142,845,949 - 142,896,583 (+)	NCBI		HuRef
CHM1_1	X	154,211,322 - 154,263,032 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	153,307,916 - 153,359,479 (+)	NCBI		T2T-CHM13v2.0

Brcc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	74,460,234 - 74,499,307 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	74,460,234 - 74,497,607 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	75,416,628 - 75,455,702 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	75,416,628 - 75,454,001 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	72,661,967 - 72,701,040 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	71,669,420 - 71,706,717 (+)	NCBI		MGSCv36	mm8
Celera	X	66,818,616 - 66,858,058 (+)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	38.22	NCBI

Brcc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	2,073,927 - 2,076,469 (+)	NCBI		GRCr8
mRatBN7.2	9	1,986,942 - 1,989,484 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	1,986,575 - 1,991,080 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	2,421,214 - 2,423,760 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	7,770,588 - 7,773,134 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	6,726,439 - 6,728,985 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	9,863,380 - 9,865,920 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	9,863,404 - 9,865,920 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	8,864,902 - 8,867,442 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	6,530,917 - 6,533,459 (-)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

BRCC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	155,049,262 - 155,097,994 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	155,052,870 - 155,104,458 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	144,550,320 - 144,592,795 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	154,389,179 - 154,431,616 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	154,389,283 - 154,428,669 (+)	Ensembl	panpan1.1		panPan2

BRCC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	123,081,262 - 123,143,509 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	123,081,050 - 123,140,133 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	108,074,648 - 108,136,853 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	126,208,828 - 126,271,057 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	126,173,490 - 126,271,057 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	121,956,711 - 122,018,913 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	124,479,132 - 124,541,327 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	124,199,851 - 124,262,068 (+)	NCBI		UU_Cfam_GSD_1.0

Brcc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	119,982,639 - 120,022,107 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936927	341,253 - 376,700 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936927	341,114 - 380,817 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

BRCC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	125,383,414 - 125,439,082 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	125,383,392 - 125,439,082 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	142,991,891 - 143,046,729 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

BRCC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	129,358,759 - 129,406,293 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	129,358,862 - 129,403,352 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	67,336,845 - 67,385,677 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Brcc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624963	145,580 - 212,064 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624963	142,987 - 212,190 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013509990	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013509991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01076434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01076435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCB01038463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000000180 ⟹ ENSCLAP00000000153

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955594	554,081 - 613,661 (-)	Ensembl

RefSeq Acc Id:

ENSCLAT00000000181 ⟹ ENSCLAP00000000154

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955594	554,081 - 613,661 (-)	Ensembl

RefSeq Acc Id:

ENSCLAT00000000182 ⟹ ENSCLAP00000000155

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955594	554,081 - 613,661 (-)	Ensembl

RefSeq Acc Id:

XM_013509990 ⟹ XP_013365444

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955594	551,407 - 613,772 (-)	NCBI

Sequence:

show sequence

GCCAGGCCTGGGCGGAGCGCGGAGAGCTGGGTGCAAGGGAAGCGGCGCCGGAGCACCGGGTTGG
TCGGGCCGGAGTGGGCCTGAGGAGGACGTGAGCAAGGTCGGAGCAAGATGGCGGTGCAGGTGGT
GCAGGCGGTGCAGGCGGTTCATCTGGAATCTGACGCTTTCCTAGTTTGTCTCAACCATGCGCTG
AGCACAGAAAAGGAGGAGGTGATGGGGCTGTGTATAGGGGAGTTGAATGATGACACAAGGAGTG
ACTCCAAATTTGCATATACTGGAACTGAAATGCGCACAGTTGCTGAAAAGGTTGACACCGTCAG
AATTGTTCACATTCATTCTGTCATCATCCTCCGACGTTCTGATAAGAGGAAGGACCGAGTAGAA
ATTTCTCCAGAGCAGCTGTCTGCAGCCTCAACAGAGGCAGAGAGGTTGGCTGAAATAACAGGTC
GACCCATGAGAGTTGTGGGCTGGTATCATTCCCACCCTCATATAACTGTTTGGCCTTCACATGT
TGATGTTCGCACACAAGCCATGTACCAGATGATGGATCAAGGCTTTGTGGGTCTTATTTTTTCC
TGTTTCATAGAAGATAAAAACACAAAGACTGGCCGGGTACTGTACACTTGCTTCCAATCCATAC
AGGCCCAAAAGAGCTCAGAGTATGAGAGAATTGAAATTCCAATCCATATTGTGCCTCATGTCAC
CATTGGGAAAGTGTGTCTTGAATCAGCAGTGGAGCTTCCCAAGATCCTGTGCCAGGAGGAACAA
GATGCATATCGGAGGATTCACAGCCTTACACATCTGGACTCAGTAACCAAGATCCATAATGGCT
CAGTGTTCACCAAGAATCTGTGCAGTCAGATGTCGGCAGTCAGCGGACCTCTCCTGCAGTGGTT
GGAAGACAGACTGGAGCAAAACCAACAGCATTTGCAGGAGTTACAACAAGAAAAGGAAGAACTT
CTGCAAGAACTCTCTTCGCTAGACTGAAGCAGCTGACAAAATAGGGTATTTTTAAAAATTTGTA
TACTAAATATGGCTCAAAACTGCATATAATGCGGGTAGGCAGACAGTAGGGCAGTACTTTTATA
TTGCTTTATATATGCACAAACACAAGATGCTCTTCCTGAAAATTGCTCAAGAGCTTATTGAACC
CTTCTACTGTACCTATACGTGGTCTACAAACAGCATATACTGGATGGTTTATGTAGTATATGAA
ATTTATTTTTAAAGGCTATCAAAGTTACATTGACAAAGGCTATCTTGTAATGAAATGTCTCTGA
AGTATATTCTAAATGTTATTTTCCCGTCTTGAACTTGAAAGTCTTTGTTTCCATTTTCACTTAC
ATCCACTTCCTACACGAAGCTAAAGAAAGAAGAATACTTTCTGTTTCTACTTGTAGTTATGATG
CTTATGTTAGACAAGTGAACAGTAAGTACATGAGCGTTAGTGGAAGGAAGTATAGAGGACTCAA
CACCTCACCTCTATTTTCTGCTCTTATTGAGAGGCATATGTCTCATGGCTTCCTTCTTGACCTC
TACAGTATGTATTCTGAGACACCTATCAGTCTTAAATCTCTGTGGGTGCCCTTTTTAACCAACC
AGAGGAGTTCTAGATATTTGACTGTGAAGCAGATTCCTATTGAGCAGATCCTATCTACCTAGGA
AATTCCACTATAACATAAATGTGTTTTCTAAAACATTTAGGATTTAAAATGTAATAAAAATCAT
GCTTGGAAAGGTTCAATGACATTATTCCTAGTATGTGTAGCCACAAATGATAAATACGTGTCTT
CAGAAAAGATTCAGGGCTATCTCATACTAAAAAAACCTGGGAATTGGAGGAGATCAAAAGAAGG
AAAACAGAACCTCAATCACAACAGTAAAATAGGTGTTTTGGGCTTTACATCTGGTTTCTTACCA
AATTAGTGTTTTTCAGATTGCATACTGAAATACATGTGGGGCTGAGTATGTTGTAGTCTAGAAA
TGTGCATGAACTGCATGCTGACTCTGAGGCACACTTACATCTGAAAACTGCCCCGGTGCATATG
GAATGTAAATCCTGGTTTTCTCCCTAATTCCCTGGTGCCACAGTTCTTCTCTATTCTTTCTTCC
CCCTAGAGGACAGATGAAAATACCTTGCATAAAATTAAGATAAACCAATTTTGATGAAGAAAAA
ATTGGAGAATTCACATTACCTGACTTCACTTTTACTATAAAACTAGAGTAATCAGGATGGCATG
GTAATGGCAGAGAGATAGACACACAGATCAGTGGAACAGAAGATAGAACCTAGAAATAGATTCA
CATAAATATGCCCAACTAATTTTGACAAAATCCAAAAGCAGTTTAATGCAGAAAAGATACACTT
TTCAGCAAATCATGCTGCAGCCCTCAAATGTCCATAGGCAAAAAACAAAACAAAGCTCAGCTAA
CTCATGCATGCTGTAAAACTTACCTCAAAATATATCATTCATTTAAATGTAAGATGTAAAGCTG
TAACTTTTAGGGGAAAAAAGTCATAGCAAAAAAGTCTTTAGGAGATAAATTATTAGACTTCAAC
TCAAAAGTACAGTTCATAAGAGAAAAAAGTTATACAATGGACTTTGTCAAAATTTTAAAAATTG
CTCTGTAAAAAAAATCTAAGAGGAAAAGACAAGCTACAGTTTTAAATTATTTGCAAACCATAGA
GTGTCTGATCAATGTGGAAATACACAGTGAGATCAAACTCCACAATAAAATAAAATCCAATTAG
AAAATGAGCTAAAGACATGAATGGACATTTCACCAGAGAGGATATATGGATGGCAGGTAATCAC
TTGAAAACATACTGAACTTCATGAGTCATCAGGAATTGCAAAGTAAAATCACAGTGCAGTATGA
TTTAGCAGAAGGGCTAATGCAAAAAGAGTGAAAACGTCAAATGCTGTTGAAGGGGCAAACTAGA
ATTTCTCATATGTTGATTATAAGAATGTAAAATGGTATAGCCAGTCTGGAAGAGTTGGGAAATT
TCTTCTAAAATTAAACATACTATATAACCCAGAAAATGCTCTTCTGGACATTTATCCCAGAGAA
ATGAAAACCTTTGTGGGCACAGTAACTTGGACACAAGTTTTCATAGTGGCTTTATTCAAAACCT
GTGAACAGTGCAGATGTCCTGCAGCGGGTAACACAAGGAGTTCCTTTGTGCTTATGGAGCAGTT
TTTGATCATCATAGTGGTGTTGAGCACGTGAATTTATACTTAAGCTGAACAAATCATCTGTACC
CTCAAATATTGCCTTGCAATGAAAAGGAACAGACTATGAACACACACAAACTGAGATGAACCTC
AGGGGTGTTAATAGTGAATTGTAAAAGCAATATCAAAAGGTTACATATTGTATGACCGCATTTG
TACAACATTCTTAAAATGTCAAAATTATAGAAACGAAGAACAGATTAATGAGTGCCAGGGATGG
GGACTGGATGGGGTACGGCTTCTGTGTGACTCTTTAGGGATGACACAAGGAGTTCCTCTGTGCT
GATGGAGCAGTTTTCTAATCTTAATTGTGGTGTTGAATACATGAATTTACTGATGCTAAAGCTG
TGTGATCTGTACACACATAAATGAATGCATGTAAAATCTAGTGAAACTGAATAAAGTCTGTAGT
CTGCTAAACAGTA

hide sequence

RefSeq Acc Id:

XM_013509991 ⟹ XP_013365445

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955594	551,407 - 613,772 (-)	NCBI

Sequence:

show sequence

GCCAGGCCTGGGCGGAGCGCGGAGAGCTGGGTGCAAGGGAAGCGGCGCCGGAGCACCGGGTTGG
TCGGGCCGGAGTGGGCCTGAGGAGGACGTGAGCAAGGTCGGAGCAAGATGGCGGTGCAGGTGGT
GCAGGCGGTGCAGGCGGTTCATCTGGAATCTGACGCTTTCCTAGTTTGTCTCAACCATGCGCTG
AGCACAGAAAAGGAGGAGGTGATGGGGCTGTGTATAGGGGAGGTTGACACCGTCAGAATTGTTC
ACATTCATTCTGTCATCATCCTCCGACGTTCTGATAAGAGGAAGGACCGAGTAGAAATTTCTCC
AGAGCAGCTGTCTGCAGCCTCAACAGAGGCAGAGAGGTTGGCTGAAATAACAGGTCGACCCATG
AGAGTTGTGGGCTGGTATCATTCCCACCCTCATATAACTGTTTGGCCTTCACATGTTGATGTTC
GCACACAAGCCATGTACCAGATGATGGATCAAGGCTTTGTGGGTCTTATTTTTTCCTGTTTCAT
AGAAGATAAAAACACAAAGACTGGCCGGGTACTGTACACTTGCTTCCAATCCATACAGGCCCAA
AAGAGCTCAGAGTATGAGAGAATTGAAATTCCAATCCATATTGTGCCTCATGTCACCATTGGGA
AAGTGTGTCTTGAATCAGCAGTGGAGCTTCCCAAGATCCTGTGCCAGGAGGAACAAGATGCATA
TCGGAGGATTCACAGCCTTACACATCTGGACTCAGTAACCAAGATCCATAATGGCTCAGTGTTC
ACCAAGAATCTGTGCAGTCAGATGTCGGCAGTCAGCGGACCTCTCCTGCAGTGGTTGGAAGACA
GACTGGAGCAAAACCAACAGCATTTGCAGGAGTTACAACAAGAAAAGGAAGAACTTCTGCAAGA
ACTCTCTTCGCTAGACTGAAGCAGCTGACAAAATAGGGTATTTTTAAAAATTTGTATACTAAAT
ATGGCTCAAAACTGCATATAATGCGGGTAGGCAGACAGTAGGGCAGTACTTTTATATTGCTTTA
TATATGCACAAACACAAGATGCTCTTCCTGAAAATTGCTCAAGAGCTTATTGAACCCTTCTACT
GTACCTATACGTGGTCTACAAACAGCATATACTGGATGGTTTATGTAGTATATGAAATTTATTT
TTAAAGGCTATCAAAGTTACATTGACAAAGGCTATCTTGTAATGAAATGTCTCTGAAGTATATT
CTAAATGTTATTTTCCCGTCTTGAACTTGAAAGTCTTTGTTTCCATTTTCACTTACATCCACTT
CCTACACGAAGCTAAAGAAAGAAGAATACTTTCTGTTTCTACTTGTAGTTATGATGCTTATGTT
AGACAAGTGAACAGTAAGTACATGAGCGTTAGTGGAAGGAAGTATAGAGGACTCAACACCTCAC
CTCTATTTTCTGCTCTTATTGAGAGGCATATGTCTCATGGCTTCCTTCTTGACCTCTACAGTAT
GTATTCTGAGACACCTATCAGTCTTAAATCTCTGTGGGTGCCCTTTTTAACCAACCAGAGGAGT
TCTAGATATTTGACTGTGAAGCAGATTCCTATTGAGCAGATCCTATCTACCTAGGAAATTCCAC
TATAACATAAATGTGTTTTCTAAAACATTTAGGATTTAAAATGTAATAAAAATCATGCTTGGAA
AGGTTCAATGACATTATTCCTAGTATGTGTAGCCACAAATGATAAATACGTGTCTTCAGAAAAG
ATTCAGGGCTATCTCATACTAAAAAAACCTGGGAATTGGAGGAGATCAAAAGAAGGAAAACAGA
ACCTCAATCACAACAGTAAAATAGGTGTTTTGGGCTTTACATCTGGTTTCTTACCAAATTAGTG
TTTTTCAGATTGCATACTGAAATACATGTGGGGCTGAGTATGTTGTAGTCTAGAAATGTGCATG
AACTGCATGCTGACTCTGAGGCACACTTACATCTGAAAACTGCCCCGGTGCATATGGAATGTAA
ATCCTGGTTTTCTCCCTAATTCCCTGGTGCCACAGTTCTTCTCTATTCTTTCTTCCCCCTAGAG
GACAGATGAAAATACCTTGCATAAAATTAAGATAAACCAATTTTGATGAAGAAAAAATTGGAGA
ATTCACATTACCTGACTTCACTTTTACTATAAAACTAGAGTAATCAGGATGGCATGGTAATGGC
AGAGAGATAGACACACAGATCAGTGGAACAGAAGATAGAACCTAGAAATAGATTCACATAAATA
TGCCCAACTAATTTTGACAAAATCCAAAAGCAGTTTAATGCAGAAAAGATACACTTTTCAGCAA
ATCATGCTGCAGCCCTCAAATGTCCATAGGCAAAAAACAAAACAAAGCTCAGCTAACTCATGCA
TGCTGTAAAACTTACCTCAAAATATATCATTCATTTAAATGTAAGATGTAAAGCTGTAACTTTT
AGGGGAAAAAAGTCATAGCAAAAAAGTCTTTAGGAGATAAATTATTAGACTTCAACTCAAAAGT
ACAGTTCATAAGAGAAAAAAGTTATACAATGGACTTTGTCAAAATTTTAAAAATTGCTCTGTAA
AAAAAATCTAAGAGGAAAAGACAAGCTACAGTTTTAAATTATTTGCAAACCATAGAGTGTCTGA
TCAATGTGGAAATACACAGTGAGATCAAACTCCACAATAAAATAAAATCCAATTAGAAAATGAG
CTAAAGACATGAATGGACATTTCACCAGAGAGGATATATGGATGGCAGGTAATCACTTGAAAAC
ATACTGAACTTCATGAGTCATCAGGAATTGCAAAGTAAAATCACAGTGCAGTATGATTTAGCAG
AAGGGCTAATGCAAAAAGAGTGAAAACGTCAAATGCTGTTGAAGGGGCAAACTAGAATTTCTCA
TATGTTGATTATAAGAATGTAAAATGGTATAGCCAGTCTGGAAGAGTTGGGAAATTTCTTCTAA
AATTAAACATACTATATAACCCAGAAAATGCTCTTCTGGACATTTATCCCAGAGAAATGAAAAC
CTTTGTGGGCACAGTAACTTGGACACAAGTTTTCATAGTGGCTTTATTCAAAACCTGTGAACAG
TGCAGATGTCCTGCAGCGGGTAACACAAGGAGTTCCTTTGTGCTTATGGAGCAGTTTTTGATCA
TCATAGTGGTGTTGAGCACGTGAATTTATACTTAAGCTGAACAAATCATCTGTACCCTCAAATA
TTGCCTTGCAATGAAAAGGAACAGACTATGAACACACACAAACTGAGATGAACCTCAGGGGTGT
TAATAGTGAATTGTAAAAGCAATATCAAAAGGTTACATATTGTATGACCGCATTTGTACAACAT
TCTTAAAATGTCAAAATTATAGAAACGAAGAACAGATTAATGAGTGCCAGGGATGGGGACTGGA
TGGGGTACGGCTTCTGTGTGACTCTTTAGGGATGACACAAGGAGTTCCTCTGTGCTGATGGAGC
AGTTTTCTAATCTTAATTGTGGTGTTGAATACATGAATTTACTGATGCTAAAGCTGTGTGATCT
GTACACACATAAATGAATGCATGTAAAATCTAGTGAAACTGAATAAAGTCTGTAGTCTGCTAAA
CAGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_013365444	(Get FASTA)	NCBI Sequence Viewer
	XP_013365445	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000000153
	ENSCLAP00000000153.1
	ENSCLAP00000000154.1
	ENSCLAP00000000155.1

RefSeq Acc Id:	XP_013365445 ⟸ XM_013509991
- Peptide Label:	isoform X2
- UniProtKB:	A0A8C2UHH6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGEVDTVRIVHIHSVIILRRSDKRKD RVEISPEQLSAASTEAERLAEITGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGL IFSCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHVTIGKVCLESAVELPKILCQ EEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQELQQEK EELLQELSSLD hide sequence

RefSeq Acc Id:	XP_013365444 ⟸ XM_013509990
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2YI14 (UniProtKB/TrEMBL), A0A8C2UHH6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDTRSDSKFAYTGTEMRTVAE KVDTVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAEITGRPMRVVGWYHSHPHIT VWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIH IVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSG PLLQWLEDRLEQNQQHLQELQQEKEELLQELSSLD hide sequence

RefSeq Acc Id:

ENSCLAP00000000154 ⟸ ENSCLAT00000000181

RefSeq Acc Id:

ENSCLAP00000000155 ⟸ ENSCLAT00000000182

RefSeq Acc Id:

ENSCLAP00000000153 ⟸ ENSCLAT00000000180

Protein Domains

MPN

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000000163	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000000180	ENTREZGENE
	ENSCLAT00000000180.1	UniProtKB/TrEMBL
	ENSCLAT00000000181.1	UniProtKB/TrEMBL
	ENSCLAT00000000182.1	UniProtKB/TrEMBL
Gene3D-CATH	Cytidine Deaminase, domain 2	UniProtKB/TrEMBL
InterPro	BRCC36_C	UniProtKB/TrEMBL
	JAMM/MPN+_dom	UniProtKB/TrEMBL
	MPN	UniProtKB/TrEMBL
	MPN_BRCC36	UniProtKB/TrEMBL
NCBI Gene	Brcc3	ENTREZGENE
PANTHER	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED	UniProtKB/TrEMBL
	LYS-63-SPECIFIC DEUBIQUITINASE BRCC36-RELATED	UniProtKB/TrEMBL
Pfam	BRCC36_C	UniProtKB/TrEMBL
	JAB	UniProtKB/TrEMBL
PROSITE	MPN	UniProtKB/TrEMBL
SMART	JAB_MPN	UniProtKB/TrEMBL
Superfamily-SCOP	JAB1/MPN domain	UniProtKB/TrEMBL
UniProt	A0A8C2UHH6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2ULF9_CHILA	UniProtKB/TrEMBL
	A0A8C2YI14	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Brcc3	BRCA1/BRCA2-containing complex subunit 3		BRCA1/BRCA2-containing complex, subunit 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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