| 1308253 | Bin3 | bridging integrator 3 | INVOLVED IN intracellular protein localization (ortholog); myoblast migration involved in skeletal muscle regeneration (ortholog); regulation of lamellipodium assembly (ortholog); FOUND IN actin cytoskeleton (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; clofibric acid | 15 | 51583474 | 51622329 | Rat | 68 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1317921 | BIN3 | bridging integrator 3 | The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008] | 8 | 22620418 | 22669121 | Human | 71 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1317922 | Bin3 | bridging integrator 3 | Predicted to contribute to lipid binding activity. Acts upstream of or within myoblast migration involved in skeletal muscle regeneration; regulation of lamellipodium assembly; and skeletal muscle fiber development. Located in actin cytoskeleton. Is expressed in several structures, including 1st bra nchial arch; lens; limb; and testis. Orthologous to human BIN3 (bridging integrator 3). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 70337538 | 70375413 | Mouse | 82 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8731531 | Bin3 | bridging integrator 3 | INVOLVED IN intracellular protein localization (ortholog); myoblast migration involved in skeletal muscle regeneration (ortholog); regulation of lamellipodium assembly (ortholog); FOUND IN actin cytoskeleton (ortholog) | NW_004955403 | 46042885 | 46085029 | Chinchilla | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11744923 | BIN3 | bridging integrator 3 | ENCODES a protein that exhibits lipid binding (inferred); INVOLVED IN myoblast migration involved in skeletal muscle regeneration (ortholog); regulation of lamellipodium assembly (ortholog); skeletal muscle fiber development (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); c ytoskeleton (inferred) | 8 | 21870784 | 21919077 | Bonobo | 21 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12257798 | BIN3 | bridging integrator 3 | INVOLVED IN myoblast migration involved in skeletal muscle regeneration (ortholog); regulation of lamellipodium assembly (ortholog); skeletal muscle fiber development (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); cytoskeleton (inferred) | 25 | 34615683 | 34659739 | Dog | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14038649 | BIN3 | bridging integrator 3 | INVOLVED IN myoblast migration involved in skeletal muscle regeneration (ortholog); regulation of lamellipodium assembly (ortholog); skeletal muscle fiber development (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); cytoskeleton (inferred) | | | | Pig | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18927496 | Bin3 | bridging integrator 3 | ENCODES a protein that exhibits lipid binding (inferred); INVOLVED IN intracellular protein localization (ortholog); myoblast migration involved in skeletal muscle regeneration (ortholog); regulation of lamellipodium assembly (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); cytoskeleton (inferred) | | | | Naked Mole-Rat | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626140204 | Bin3 | bridging integrator 3 | INVOLVED IN intracellular protein localization (ortholog); myoblast migration involved in skeletal muscle regeneration (ortholog); regulation of lamellipodium assembly (ortholog); FOUND IN actin cytoskeleton (ortholog) | | | | Black Rat | 9 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14381766 | bin3 | | | | | | Fly | | symbol | gene, null |
| 18640103 | BIN3 | bridging integrator 3 | ENCODES a protein that exhibits lipid binding (inferred); INVOLVED IN myoblast migration involved in skeletal muscle regeneration (ortholog); regulation of lamellipodium assembly (ortholog); skeletal muscle fiber development (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); c ytoskeleton (inferred) | | | | Green Monkey | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155250561 | bin3 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155232383 | bin3.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155258278 | bin3.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 2307244 | BIN3-IT1 | BIN3 intronic transcript 1 | INTERACTS WITH methotrexate; paracetamol; sodium arsenite | 8 | 22640371 | 22642209 | Human | 4 | symbol , GTEx , COSMIC , name , Human Proteome Map | gene, ncrna, VALIDATED [RefSeq] |
| 12470462 | Egr3 | early growth response 3 | ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN actin cortical patch localization (inferred); cell division (inferred); cell migration involv ed in sprouting angiogenesis (inferred); ASSOCIATED WITH Ataxia (ortholog); COVID-19 (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); cytoskeleton (inferred) | NW_004936555 | 6347446 | 6393784 | Squirrel | 38 | old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 1603022 | MEPCE | methylphosphate capping enzyme | Enables 7SK snRNA binding activity and RNA 5'-gamma-phosphate methyltransferase activity. Involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Located in nucleus. Part of 7SK snRNP. [provided by Alliance of Genome Resources, Jul 2025] | 7 | 100428790 | 100434118 | Human | 97 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 1557769 | Mepce | methylphosphate capping enzyme | Predicted to enable 7SK snRNA binding activity and RNA 5'-gamma-phosphate methyltransferase activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in nucleus. Predicted t o be part of 7SK snRNP. Is expressed in several structures, including adrenal gland; alimentary system; brain; early conceptus; and genitourinary system. Orthologous to human MEPCE (methylphosphate capping enzyme). [provided by Alliance of Genome Resources, Jul 2025] | 5 | 137780168 | 137785915 | Mouse | 119 | old_gene_name | gene, protein-coding, VALIDATED [RefSeq] |
| 12097175 | MEPCE | methylphosphate capping enzyme | ENCODES a protein that exhibits 7SK snRNA binding (inferred); methyltransferase activity (inferred); O-methyltransferase activity (inferred); INVOLVED IN negative regulation of transcription by RNA polymerase II (ortholog); positive regulation of G1/S transition of mitotic cell cycle (ortholog); FOU ND IN 7SK snRNP (inferred); nucleus (inferred); ribonucleoprotein complex (inferred) | 6 | 9234316 | 9239160 | Dog | 26 | old_gene_name | gene, protein-coding, MODEL [RefSeq] |
