Bin3 (bridging integrator 3) - Rat Genome Database

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Gene: Bin3 (bridging integrator 3) Mus musculus
Analyze
Symbol: Bin3
Name: bridging integrator 3
RGD ID: 1317922
MGI Page MGI
Description: Predicted to contribute to lipid binding activity. Acts upstream of or within myoblast migration involved in skeletal muscle regeneration; regulation of lamellipodium assembly; and skeletal muscle fiber development. Located in actin cytoskeleton. Is expressed in 1st branchial arch mandibular component; 1st branchial arch maxillary component; embryo; limb; and testis. Orthologous to human BIN3 (bridging integrator 3); INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1700015F07Rik; bridging integrator-3
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm15636  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,337,538 - 70,375,413 (+)NCBIGRCm39mm39
GRCm39 Ensembl1470,337,554 - 70,375,655 (+)Ensembl
GRCm381470,100,089 - 70,137,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,100,105 - 70,138,206 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,499,952 - 70,538,013 (+)NCBIGRCm37mm9NCBIm37
MGSCv361468,835,225 - 68,873,286 (+)NCBImm8
Celera1467,640,607 - 67,678,945 (+)NCBICelera
Cytogenetic Map14D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:10349636   PMID:11042159   PMID:11076861   PMID:11274158   PMID:12477932   PMID:12533789   PMID:14610273   PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:17332066  
PMID:18339847   PMID:18799693   PMID:21873635   PMID:22566646   PMID:23872330  


Genomics

Comparative Map Data
Bin3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,337,538 - 70,375,413 (+)NCBIGRCm39mm39
GRCm39 Ensembl1470,337,554 - 70,375,655 (+)Ensembl
GRCm381470,100,089 - 70,137,964 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,100,105 - 70,138,206 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,499,952 - 70,538,013 (+)NCBIGRCm37mm9NCBIm37
MGSCv361468,835,225 - 68,873,286 (+)NCBImm8
Celera1467,640,607 - 67,678,945 (+)NCBICelera
Cytogenetic Map14D2NCBI
BIN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl822,620,418 - 22,669,148 (-)EnsemblGRCh38hg38GRCh38
GRCh38822,620,418 - 22,669,148 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37822,477,931 - 22,526,634 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,533,876 - 22,582,606 (-)NCBINCBI36hg18NCBI36
Build 34822,533,890 - 22,582,540NCBI
Celera821,439,785 - 21,488,652 (-)NCBI
Cytogenetic Map8p21.3NCBI
HuRef821,021,078 - 21,070,156 (-)NCBIHuRef
CHM1_1822,680,143 - 22,728,895 (-)NCBICHM1_1
Bin3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21545,173,725 - 45,212,607 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1551,779,839 - 51,818,699 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01551,799,339 - 51,818,697 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01555,525,398 - 55,544,850 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,519,884 - 50,539,242 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11550,535,662 - 50,555,015 (+)NCBI
Celera1544,872,895 - 44,892,253 (+)NCBICelera
Cytogenetic Map15p11NCBI
Bin3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540346,042,885 - 46,085,029 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540346,042,885 - 46,085,029 (-)NCBIChiLan1.0ChiLan1.0
BIN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1818,809,582 - 18,858,912 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,809,582 - 18,858,912 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0821,870,784 - 21,919,077 (-)NCBIMhudiblu_PPA_v0panPan3
BIN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12534,615,683 - 34,659,739 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2534,615,249 - 34,659,755 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,205,447 - 35,249,488 (+)NCBI
ROS_Cfam_1.02534,825,227 - 34,869,290 (+)NCBI
UMICH_Zoey_3.12534,771,458 - 34,815,744 (+)NCBI
UNSW_CanFamBas_1.02534,625,780 - 34,669,825 (+)NCBI
UU_Cfam_GSD_1.02534,781,289 - 34,825,349 (+)NCBI
BIN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl146,874,281 - 6,923,361 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1146,874,281 - 6,926,950 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2147,354,594 - 7,403,650 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BIN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,700,664 - 20,748,775 (-)NCBI
ChlSab1.1 Ensembl820,701,390 - 20,725,210 (-)Ensembl
Vero_WHO_p1.0NW_02366605221,478,444 - 21,526,859 (+)NCBI
Bin3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475818,121,125 - 18,163,142 (-)NCBI

Position Markers
Bin3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14D2UniSTS
cM Map14 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420837405121032392Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142101238271648361Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143060000087700000Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143719272871192863Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4009986274099862Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144272496776725144Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144272496776725144Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144279982176799969Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144282839876828596Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144282839876828596Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144921797683218107Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145204453586044676Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145352385687524089Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145370000087700000Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145584494189845069Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145630930590309501Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1457942183101622037Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146216002096160240Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1469834541103834541Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir184mmu-miR-184-3pMirecordsexternal_info{unchanged}NA20795863

Predicted Target Of
Summary Value
Count of predictions:366
Count of miRNA genes:264
Interacting mature miRNAs:304
Transcripts:ENSMUST00000022680
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001360404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006519332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011245124 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030247902 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC151836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF244361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF271733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI464318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK005992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK170915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK184053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB682940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026543 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA562064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CX565660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000022680   ⟹   ENSMUSP00000022680
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1470,100,105 - 70,138,206 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226385
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1470,100,123 - 70,134,479 (+)Ensembl
RefSeq Acc Id: ENSMUST00000227841
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1470,100,106 - 70,124,243 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228049
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1470,100,165 - 70,134,526 (+)Ensembl
RefSeq Acc Id: ENSMUST00000228717   ⟹   ENSMUSP00000154413
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1470,100,138 - 70,128,882 (+)Ensembl
RefSeq Acc Id: NM_001360404   ⟹   NP_001347333
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,337,542 - 70,375,410 (+)NCBI
GRCm381470,100,093 - 70,137,961 (+)NCBI
Sequence:
RefSeq Acc Id: NM_021328   ⟹   NP_067303
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,337,542 - 70,375,410 (+)NCBI
GRCm381470,100,093 - 70,137,961 (+)NCBI
MGSCv371470,499,952 - 70,538,013 (+)RGD
Celera1467,640,607 - 67,678,945 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006519330   ⟹   XP_006519393
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,337,538 - 70,375,413 (+)NCBI
GRCm381470,100,089 - 70,137,247 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006519332   ⟹   XP_006519395
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,337,539 - 70,375,413 (+)NCBI
GRCm381470,100,090 - 70,137,964 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011245124   ⟹   XP_011243426
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,361,290 - 70,375,413 (+)NCBI
GRCm381470,123,841 - 70,137,964 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247901   ⟹   XP_030103761
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,337,539 - 70,375,413 (+)NCBI
GRCm381470,100,090 - 70,137,964 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247902   ⟹   XP_030103762
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,337,539 - 70,375,413 (+)NCBI
GRCm381470,100,090 - 70,137,964 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158770   ⟹   XP_036014663
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,337,546 - 70,375,413 (+)NCBI
RefSeq Acc Id: XM_036158771   ⟹   XP_036014664
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,343,377 - 70,375,413 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_067303   ⟸   NM_021328
- Peptide Label: isoform 1
- UniProtKB: Q9JI08 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006519393   ⟸   XM_006519330
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006519395   ⟸   XM_006519332
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011243426   ⟸   XM_011245124
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_030103761   ⟸   XM_030247901
- Peptide Label: isoform X3
RefSeq Acc Id: XP_030103762   ⟸   XM_030247902
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001347333   ⟸   NM_001360404
- Peptide Label: isoform 2
RefSeq Acc Id: ENSMUSP00000022680   ⟸   ENSMUST00000022680
RefSeq Acc Id: ENSMUSP00000154413   ⟸   ENSMUST00000228717
RefSeq Acc Id: XP_036014663   ⟸   XM_036158770
- Peptide Label: isoform X2
RefSeq Acc Id: XP_036014664   ⟸   XM_036158771
- Peptide Label: isoform X2
Protein Domains
BAR

Promoters
RGD ID:8682880
Promoter ID:EPDNEW_M19471
Type:initiation region
Name:Bin3_1
Description:Mus musculus bridging integrator 3 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381470,100,137 - 70,100,197EPDNEW
RGD ID:6824726
Promoter ID:MM_KWN:17355
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000111041
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,499,614 - 70,500,114 (+)MPROMDB
RGD ID:6849023
Promoter ID:MM_XEF:2320
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour
Transcripts:NM_001095301
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361470,523,776 - 70,524,276 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1929883 AgrOrtholog
Ensembl Genes ENSMUSG00000022089 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000022680 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000154413 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000022680 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000228717 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BAR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bin3_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:57784 UniProtKB/Swiss-Prot
MGD MGI:1929883 ENTREZGENE
NCBI Gene 57784 ENTREZGENE
Pfam BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bin3 PhenoGen
PROSITE BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2I3BR15_MOUSE UniProtKB/TrEMBL
  BIN3_MOUSE UniProtKB/Swiss-Prot
  Q3TC47_MOUSE UniProtKB/TrEMBL
  Q9JI08 ENTREZGENE