BIN3 (bridging integrator 3) - Rat Genome Database

Name: BIN3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: BIN3 (bridging integrator 3) Chlorocebus sabaeus

Analyze

Symbol:

BIN3

Name:

bridging integrator 3

RGD ID:

18640103

Description:

ENCODES a protein that exhibits lipid binding (inferred); INVOLVED IN myoblast migration involved in skeletal muscle regeneration (ortholog); regulation of lamellipodium assembly (ortholog); skeletal muscle fiber development (ortholog); ASSOCIATED WITH Conotruncal Cardiac Defects (ortholog); genetic disease (ortholog); FOUND IN actin cytoskeleton (inferred); cytoplasm (inferred); cytoskeleton (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	BIN3 (bridging integrator 3)	NCBI	Ortholog
Mus musculus (house mouse):	Bin3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Bin3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Bin3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	BIN3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	BIN3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	BIN3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Bin3 (bridging integrator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	20,700,664 - 20,748,775 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	20,701,390 - 20,725,210 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	21,478,444 - 21,526,859 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Conotruncal Cardiac Defects (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cortical patch localization (IEA)

endocytosis (IEA)

myoblast migration involved in skeletal muscle regeneration (IEA,ISO)

plasma membrane tubulation (IEA)

protein localization (IEA)

regulation of lamellipodium assembly (IEA,ISO)

skeletal muscle fiber development (IEA,ISO)

skeletal muscle tissue regeneration (IEA,ISO)

unidimensional cell growth (IEA)

Cellular Component

actin cytoskeleton (IEA)

cytoplasm (IEA)

cytoskeleton (IEA)

mating projection tip (IEA)

medial cortex (IEA)

Rvs161p-Rvs167p complex (IEA)

Molecular Function

lipid binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

BIN3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	20,700,664 - 20,748,775 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	20,701,390 - 20,725,210 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	21,478,444 - 21,526,859 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

BIN3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	22,620,418 - 22,669,121 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	22,620,418 - 22,669,148 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	22,477,931 - 22,526,634 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	22,533,876 - 22,582,606 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	22,533,890 - 22,582,540	NCBI
Celera	8	21,439,785 - 21,488,652 (-)	NCBI		Celera
Cytogenetic Map	8	p21.3	NCBI
HuRef	8	21,021,078 - 21,070,156 (-)	NCBI		HuRef
CHM1_1	8	22,680,143 - 22,728,895 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	22,894,322 - 22,943,373 (-)	NCBI		T2T-CHM13v2.0

Bin3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	70,337,538 - 70,375,413 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	70,337,554 - 70,375,655 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	70,100,089 - 70,137,964 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	70,100,105 - 70,138,206 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	70,499,952 - 70,538,013 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	68,835,225 - 68,873,286 (+)	NCBI		MGSCv36	mm8
Celera	14	67,640,607 - 67,678,945 (+)	NCBI		Celera
Cytogenetic Map	14	D2	NCBI
cM Map	14	36.21	NCBI

Bin3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	51,583,474 - 51,622,329 (+)	NCBI		GRCr8
mRatBN7.2	15	45,173,725 - 45,212,607 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	45,173,732 - 45,212,604 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	49,291,591 - 49,330,460 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	50,403,086 - 50,441,954 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	47,262,410 - 47,301,270 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	51,799,339 - 51,818,697 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	51,779,839 - 51,818,699 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	55,525,398 - 55,544,850 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	50,519,884 - 50,539,242 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	50,535,662 - 50,555,015 (+)	NCBI
Celera	15	44,872,895 - 44,892,253 (+)	NCBI		Celera
Cytogenetic Map	15	p11	NCBI

Bin3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	46,042,885 - 46,085,029 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	46,042,885 - 46,085,029 (-)	NCBI	ChiLan1.0	ChiLan1.0

BIN3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	41,127,684 - 41,173,953 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	16,852,857 - 16,901,510 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	21,870,784 - 21,919,077 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	18,809,582 - 18,858,912 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	18,809,582 - 18,858,912 (-)	Ensembl	panpan1.1		panPan2

BIN3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	34,615,683 - 34,659,739 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	34,615,249 - 34,659,755 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	35,205,447 - 35,249,488 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	34,825,227 - 34,869,290 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	34,825,174 - 34,869,586 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	34,771,458 - 34,815,744 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	34,625,780 - 34,669,825 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	34,781,289 - 34,825,349 (+)	NCBI		UU_Cfam_GSD_1.0

BIN3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	6,874,300 - 6,889,133 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	6,874,281 - 6,926,950 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	7,354,594 - 7,403,650 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Bin3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	18,121,125 - 18,163,044 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	18,121,125 - 18,163,142 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	36	14	46
Low		6	14
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007961907	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000014401 ⟹ ENSCSAP00000012375

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	8	20,701,390 - 20,725,210 (-)	Ensembl

RefSeq Acc Id:

XM_007961907 ⟹ XP_007960098

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	8	20,700,664 - 20,748,775 (-)	NCBI
Vero_WHO_p1.0	NW_023666052	21,478,444 - 21,526,859 (+)	NCBI

Sequence:

show sequence

CGTCACTTCCTGGAGACTGGCTGAATCCGGAAGTGATCCCAGAGGAACGAGTTGTGGCTGAGGA
CCCCGGCGGCAGGCCCAGGTTCGGGACCATGAGCTGGATTCCTTTTAAGATTGGGCAGCCCAAG
AAACAGATTGTGCCCAAAACAGTGGAGAGAGACTTTGAAAGGGAGTATGGAAAACTTCAGCAGC
TGGAAGAGCAGACCCGGAAGCTGCAGAAAGACATGAAGAAGAGCACCGACGCTGACCTGGCCAT
GTCAAAATCTGCCGTGAAGATATCCTTGGACTTACTCTCCAACCCCCTCTGCGAGCAAGACCAG
GACCTTCTGAGCATGGTGACAGCCCTGGACACGGCCATGAAGCGGATGGACGCCTTCAACCAGG
AAAAGGTGAACCAGATCCAAAAGACTGTGATCGAGCCCTTAAAAAAGTTCGGCAGCGTCTTCCC
GAGCCTCAACATGGCGGTGAAGCGGCGGGAACAGGCCTTGCAGGACTACAGGAGGCTGCAGGCC
AAGGTGGAGAAGTATGAGGAAAAGGAGAAGACGGGGCCAGTGCTGGCCAAGCTCCACCAGGCGC
GAGAGGAGCTGCGGCCTGTGCGGGAGGACTTCGAGGCCAAGAACAGGCAGCTGCTGGAGGAGAT
GCCGCGCTTCTACGGCAGCCGCCTTGACTACTTCCAGCCCAGCTTTGAGTCCCTCATCCGAGCA
CAGGTTGTGTACTACTCGGAAATGCACAAGATCTTTGGAGACCTGACCCAGCAGCTTGACCAGC
CAGGCCACTCCGATGAGCAGCGGGAGCGGGAGAACGAGGCCAAACTCAGTGAGCTCCGGGCCCT
CTCCATTGTGGCCGATGACTGAATCCCCGTCACTCTTGGACGACTCCTGTGACACGGTCAGCCT
CGCTCGTCCTTGCCCTTCTCAGGGCTAACTGCTCCTCTCACAGGCTGGGGACAGAGGTGGCCCT
GGTTCACTTGCCGGCCCTTTGCAATGAGTGACTCTTCCTGAGCCTGGCACCAGGATCCCTAGAC
AGGCCACCATCTCCCCACTCACAGCCCCAGCAGGTAAGCAGTGTAGACAAACCCTTGGGGCTTT
TTTATTTGGAAAACCGTCCAGCATGCATCCTGGCCCATGGCCTGAGCAAGCTGCAGCCCTTCTG
AAGCCATGGGCTTTGTCGGCTCAGTTGGGGGTCTTAGCCCTGCATGCATTGTGGGCATCAAATC
TACCTCCAAAAGACCCATCCTGGGGAGCCCTCTGGCCCCTCGTTGCCTTTTCACTTAAAAGCCT
CTTTTTTCTGGGAGAGGCCCTGAACCCTGCCCAGGAGAGCTGTTCCTCCACCCTGGCAGGCCCT
CAGCCAGCTTCCCAGCAAGACAAAAGCTACCCTCGTGACTTTGGGACCCAAGTCATTGGGGTTC
CCGAGGTCACTGAGAACTGTTACCTCGGGACCTCAAACTGTCAGTGGAACTGTCCCACCACACA
GAATGTCCCACAAGAATTCGCAGGTCTCAAAGCAAAACAGTGGGTTTGTGTCTCACCTGAGTAT
TTGGAATTTTATTTTTTCAAGTAAAGTTTTCAATGAAATGTGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007960098	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000012375
	ENSCSAP00000012375.1

RefSeq Acc Id:	XP_007960098 ⟸ XM_007961907
- UniProtKB:	A0A0D9RUT6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000012375 ⟸ ENSCSAT00000014401

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000016333	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000014401.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1270.60	UniProtKB/TrEMBL
InterPro	AH/BAR_dom_sf	UniProtKB/TrEMBL
	BAR_dom	UniProtKB/TrEMBL
	BIN3/RVS161-like	UniProtKB/TrEMBL
	Bin3_BAR	UniProtKB/TrEMBL
NCBI Gene	BIN3	ENTREZGENE
PANTHER	BRIDGING INTEGRATOR 3	UniProtKB/TrEMBL
	BRIDGING INTEGRATOR 3	UniProtKB/TrEMBL
Pfam	BAR	UniProtKB/TrEMBL
PROSITE	BAR	UniProtKB/TrEMBL
SMART	BAR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF103657	UniProtKB/TrEMBL
UniProt	A0A0D9RUT6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar