| 2178 | Atp4b | ATPase H+/K+ transporting subunit beta | ENCODES a protein that exhibits heterocyclic compound binding; INVOLVED IN pH reduction; response to lipopolysaccharide; potassium ion transmembrane transport (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esomeprazole pharmacokinetics pathway ; ASSOCIATED WITH Experimental Diabetes Mellitus; obesity; atrophic gastritis (ortholog); FOUND IN apical plasma membrane (inferred); plasma membrane (inferred); sodium:potassium-exchanging ATPase complex (inferred); INTERACTS WITH ammonium chloride; atrazine; bisphenol A | 16 | 82846329 | 82855242 | Rat | 76 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10213 | Atp4b | ATPase, H+/K+ exchanging, beta polypeptide | Predicted to enable ATPase activator activity and P-type potassium:proton transporter activity. Predicted to contribute to heterocyclic compound binding activity. Predicted to be involved in intracellular monoatomic cation homeostasis; monoatomic cation transmembrane transport; and pH reduction. Pre dicted to act upstream of or within protein glycosylation and regulation of proton transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of potassium:proton exchanging ATPase complex and sodium:potassium-exchanging ATPase complex. Is expressed in alimentary system; stomach; stomach epithelium; stomach fundus; and stomach mucosa. Human ortholog(s) of this gene implicated in atrophic gastritis; autoimmune gastritis; and stomach cancer. Orthologous to human ATP4B (ATPase H+/K+ transporting subunit beta). [provided by Alliance of Genome Resources, Jul 2025] | 8 | 13436209 | 13446778 | Mouse | 99 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 737185 | ATP4B | ATPase H+/K+ transporting subunit beta | The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hy drolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes the beta subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008] | 13 | 113648804 | 113658198 | Human | 79 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8938013 | Atp4b | ATPase H+/K+ transporting subunit beta | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN pH reduction (ortholog); potassium ion transmembrane transport (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esom eprazole pharmacokinetics pathway; ASSOCIATED WITH atrophic gastritis (ortholog); autoimmune gastritis (ortholog); Experimental Diabetes Mellitus (ortholog) | NW_004955404 | 362410 | 372077 | Chinchilla | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11925348 | ATP4B | ATPase H+/K+ transporting subunit beta | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN pH reduction (ortholog); potassium ion transmembrane transport (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esom eprazole pharmacokinetics pathway; ASSOCIATED WITH atrophic gastritis (ortholog); autoimmune gastritis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN apical plasma membrane (inferred); membrane (inferred); sodium:potassium-exchanging ATPase complex (inferred) | 13 | 94796689 | 94807210 | Bonobo | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12129958 | ATP4B | ATPase H+/K+ transporting subunit beta | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN pH reduction (ortholog); potassium ion transmembrane transport (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esom eprazole pharmacokinetics pathway; ASSOCIATED WITH atrophic gastritis (ortholog); autoimmune gastritis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN apical plasma membrane (inferred); membrane (inferred); plasma membrane (inferred) | 22 | 60898801 | 60904223 | Dog | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12574560 | Atp4b | ATPase H+/K+ transporting subunit beta | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN pH reduction (ortholog); potassium ion transmembrane transport (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esom eprazole pharmacokinetics pathway; ASSOCIATED WITH atrophic gastritis (ortholog); autoimmune gastritis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN apical plasma membrane (inferred); membrane (inferred); sodium:potassium-exchanging ATPase complex (inferred) | NW_004936472 | 168745 | 173996 | Squirrel | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155240556 | atp4b | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18913908 | Atp4b | ATPase H+/K+ transporting subunit beta | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN pH reduction (ortholog); potassium ion transmembrane transport (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esom eprazole pharmacokinetics pathway; ASSOCIATED WITH atrophic gastritis (ortholog); autoimmune gastritis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN apical plasma membrane (inferred); membrane (inferred); sodium:potassium-exchanging ATPase complex (inferred) | | | | Naked Mole-Rat | 47 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626062569 | Atp4b | ATPase H+/K+ transporting subunit beta | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN pH reduction (ortholog); potassium ion transmembrane transport (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esom eprazole pharmacokinetics pathway; ASSOCIATED WITH atrophic gastritis (ortholog); autoimmune gastritis (ortholog); Experimental Diabetes Mellitus (ortholog) | | | | Black Rat | 31 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18719279 | ATP4B | ATPase H+/K+ transporting subunit beta | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN pH reduction (ortholog); potassium ion transmembrane transport (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esom eprazole pharmacokinetics pathway; ASSOCIATED WITH atrophic gastritis (ortholog); autoimmune gastritis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN apical plasma membrane (inferred); membrane (inferred); sodium:potassium-exchanging ATPase complex (inferred) | | | | Green Monkey | 46 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14142011 | ATP4B | ATPase H+/K+ transporting subunit beta | ENCODES a protein that exhibits heterocyclic compound binding (ortholog); INVOLVED IN potassium ion transmembrane transport; pH reduction (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN cimetidine pharmacodynamics pathway; esomeprazole pharmacodynamics pathway; esomeprazole ph armacokinetics pathway; ASSOCIATED WITH atrophic gastritis (ortholog); autoimmune gastritis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN apical plasma membrane (inferred); membrane (inferred); plasma membrane (inferred); INTERACTS WITH ebselen | | | | Pig | 46 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 155250140 | atp4b.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155257123 | atp4b.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 731614 | Atp1b1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | This gene encodes an integral membrane protein that comprises a subunit of an ATP-metabolizing enzyme responsible for transporting sodium and potassium ions across the plasma membrane. This enzyme regulates the electrochemical gradient of these ions in cells, and plays a central role in osmoregulati on and signal transmission in nerves and muscles, among other biological processes. The encoded protein is the non-catalytic beta subunit; it works together with a catalytic alpha subunit and a gamma subunit. [provided by RefSeq, Mar 2013] | 1 | 164264668 | 164285924 | Mouse | 505 | old_gene_symbol | gene, protein-coding, REVIEWED [RefSeq] |
| 16560244 | AP000859.1 | ATPase, H+/K+ exchanging, beta polypeptide (ATP4B) pseudogene | | | | | Human | | name | gene, processed_pseudogene |