| 2171 | Atp1b2 | ATPase Na+/K+ transporting subunit beta 2 | ENCODES a protein that exhibits P-type sodium:potassium-exchanging transporter activity; protein heterodimerization activity; ATPase activator activity (ortholog); INVOLVED IN cell-substrate adhesion (ortholog); intracellular potassium ion homeostasis (ortholog); intracellular sodium ion homeostasis (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); cerebellar ataxia (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN apical plasma membrane; cell periphery; membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil | 10 | 54817473 | 54823708 | Rat | 277 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 10208 | Atp1b2 | ATPase, Na+/K+ transporting, beta 2 polypeptide | Predicted to enable several functions, including ATPase binding activity; P-type sodium:potassium-exchanging transporter activity; and protein heterodimerization activity. Involved in cell-substrate adhesion; negative regulation of glial cell migration; and positive regulation of neuron projection d evelopment. Acts upstream of or within several processes, including brain development; motor behavior; and photoreceptor cell maintenance. Located in several cellular components, including astrocyte end-foot; cell body membrane; and external side of plasma membrane. Is expressed in several structures, including brain; early conceptus; genitourinary system; retina; and spinal cord. Orthologous to human ATP1B2 (ATPase Na+/K+ transporting subunit beta 2). [provided by Alliance of Genome Resources, Jul 2025] | 11 | 69490554 | 69496786 | Mouse | 319 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 736555 | ATP1B2 | ATPase Na+/K+ transporting subunit beta 2 | The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasm a membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] | 17 | 7646627 | 7657770 | Human | 297 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 9004461 | Atp1b2 | ATPase Na+/K+ transporting subunit beta 2 | ENCODES a protein that exhibits ATPase activator activity (ortholog); ATPase binding (ortholog); P-type sodium:potassium-exchanging transporter activity (ortholog); INVOLVED IN cell-substrate adhesion (ortholog); intracellular potassium ion homeostasis (ortholog); intracellular sodium ion homeostasi s (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); cerebellar ataxia (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte end-foot (ortholog); astrocyte projection (ortholog) | NW_004955467 | 9261775 | 9268743 | Chinchilla | 143 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12020951 | ATP1B2 | ATPase Na+/K+ transporting subunit beta 2 | ENCODES a protein that exhibits P-type sodium:potassium-exchanging transporter activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN lateral ventricle development (ortholog); motor behavior (ortholog); neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); cerebellar ataxia (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); cell periphery (ortholog) | 17 | 7681831 | 7688710 | Bonobo | 153 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12374603 | ATP1B2 | ATPase Na+/K+ transporting subunit beta 2 | ENCODES a protein that exhibits P-type sodium:potassium-exchanging transporter activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN lateral ventricle development (ortholog); motor behavior (ortholog); neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH cerebellar ataxia; autism spectrum disorder (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); cell periphery (ortholog) | 5 | 32548591 | 32553911 | Dog | 155 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12723813 | Atp1b2 | ATPase Na+/K+ transporting subunit beta 2 | ENCODES a protein that exhibits P-type sodium:potassium-exchanging transporter activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN lateral ventricle development (ortholog); motor behavior (ortholog); neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); cerebellar ataxia (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); cell periphery (ortholog) | NW_004936595 | 908019 | 914426 | Squirrel | 155 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13872770 | ATP1B2 | ATPase Na+/K+ transporting subunit beta 2 | ENCODES a protein that exhibits P-type sodium:potassium-exchanging transporter activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN lateral ventricle development (ortholog); motor behavior (ortholog); neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); cerebellar ataxia (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); cell periphery (ortholog) | | | | Pig | 155 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18622404 | ATP1B2 | ATPase Na+/K+ transporting subunit beta 2 | ENCODES a protein that exhibits P-type sodium:potassium-exchanging transporter activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN lateral ventricle development (ortholog); motor behavior (ortholog); neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); cerebellar ataxia (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); cell periphery (ortholog) | | | | Green Monkey | 165 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18931912 | Atp1b2 | ATPase Na+/K+ transporting subunit beta 2 | ENCODES a protein that exhibits ATPase binding (ortholog); P-type sodium:potassium-exchanging transporter activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN cell-substrate adhesion (ortholog); lateral ventricle development (ortholog); membrane repolarization (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); cerebellar ataxia (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte end-foot (ortholog); astrocyte projection (ortholog) | | | | Naked Mole-Rat | 148 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625913140 | Atp1b2 | ATPase Na+/K+ transporting subunit beta 2 | ENCODES a protein that exhibits ATPase activator activity (ortholog); ATPase binding (ortholog); P-type sodium:potassium-exchanging transporter activity (ortholog); INVOLVED IN cell-substrate adhesion (ortholog); intracellular potassium ion homeostasis (ortholog); intracellular sodium ion homeostasi s (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); cerebellar ataxia (ortholog); esophagus squamous cell carcinoma (ortholog); FOUND IN apical plasma membrane (ortholog); astrocyte end-foot (ortholog); astrocyte projection (ortholog) | | | | Black Rat | 143 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256271 | atp1b2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 155236010 | atp1b2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155250731 | atp1b2.S | | | | | | African Clawed Frog | | symbol | gene, null |