| 1311791 | Arpc5 | actin related protein 2/3 complex, subunit 5 | ENCODES a protein that exhibits actin filament binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN actin filament network formation; lamellipodium organization; maintenance of cell polarity; PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glu cose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH congenital hypothyroidism; Experimental Autoimmune Myasthenia Gravis; genetic disease (ortholog); FOUND IN endosome; glutamatergic synapse; growth cone; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine | 13 | 67454379 | 67463288 | Rat | 125 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1323427 | ARPC5 | actin related protein 2/3 complex subunit 5 | This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be det ermined. Alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] | 1 | 183620846 | 183635783 | Human | 170 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1323428 | Arpc5 | actin related protein 2/3 complex, subunit 5 | Predicted to enable actin filament binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including actin filament organization; lamellipodium organization; and smooth muscle cell migration. Located in lamellipodium. Is expressed in cortical plate. Human ortholog(s) of this gene implicated in immunodeficiency 133. Orthologous to human ARPC5 (actin related protein 2/3 complex subunit 5). [provided by Alliance of Genome Resources, Apr 2025] | 1 | 152642293 | 152651331 | Mouse | 143 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8929040 | Arpc5 | actin related protein 2/3 complex subunit 5 | ENCODES a protein that exhibits actin filament binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN actin filament network formation (ortholog); Arp2/3 complex-mediated actin nucleation (ortholog); cell migration (ortholog); PARTICIPATES IN insulin responsive facilitati ve sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Autoimmune Myasthenia Gravis (ortholog); genetic disease (ortholog); FOUND IN Arp2/3 protein complex (ortholog); endosome (ortholog); glutamatergic synapse (ortholog) | NW_004955406 | 22409239 | 22418950 | Chinchilla | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11797663 | ARPC5 | actin related protein 2/3 complex subunit 5 | ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); structural constituent of cytoskeleton (inferred); INVOLVED IN actin filament network formation (ortholog); lamellipodium organization (ortholog); maintenance of cell polarity (ortholog); PARTICIPATES IN ins ulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Autoimmune Myasthenia Gravis (ortholog); genetic disease (ortholog); FOUND IN endosome (ortholog); glutamatergic synapse (ortholog); growth cone (ortholog) | 1 | 159156229 | 159165898 | Bonobo | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12294389 | ARPC5 | actin related protein 2/3 complex subunit 5 | ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); structural constituent of cytoskeleton (inferred); INVOLVED IN actin filament network formation (ortholog); lamellipodium organization (ortholog); maintenance of cell polarity (ortholog); PARTICIPATES IN ins ulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Autoimmune Myasthenia Gravis (ortholog); genetic disease (ortholog); FOUND IN endosome (ortholog); glutamatergic synapse (ortholog); growth cone (ortholog) | 7 | 16976392 | 16986015 | Dog | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12622973 | Arpc5 | actin related protein 2/3 complex subunit 5 | ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); structural constituent of cytoskeleton (inferred); INVOLVED IN actin filament network formation (ortholog); lamellipodium organization (ortholog); maintenance of cell polarity (ortholog); PARTICIPATES IN ins ulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Autoimmune Myasthenia Gravis (ortholog); genetic disease (ortholog); FOUND IN endosome (ortholog); glutamatergic synapse (ortholog); growth cone (ortholog) | NW_004936481 | 6267133 | 6276173 | Squirrel | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14233047 | ARPC5 | actin related protein 2/3 complex subunit 5 | ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); structural constituent of cytoskeleton (inferred); INVOLVED IN actin filament network formation (ortholog); lamellipodium organization (ortholog); maintenance of cell polarity (ortholog); PARTICIPATES IN ins ulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Autoimmune Myasthenia Gravis (ortholog); genetic disease (ortholog); FOUND IN endosome (ortholog); glutamatergic synapse (ortholog); growth cone (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 41 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 14369536 | Arpc5 | | | | | | Fly | | symbol | gene, null |
| 18792055 | ARPC5 | actin related protein 2/3 complex subunit 5 | ENCODES a protein that exhibits actin binding (inferred); actin filament binding (inferred); structural constituent of cytoskeleton (inferred); INVOLVED IN actin filament network formation (ortholog); lamellipodium organization (ortholog); maintenance of cell polarity (ortholog); PARTICIPATES IN ins ulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Autoimmune Myasthenia Gravis (ortholog); genetic disease (ortholog); FOUND IN endosome (ortholog); glutamatergic synapse (ortholog); growth cone (ortholog) | | | | Green Monkey | 35 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18934397 | Arpc5 | actin related protein 2/3 complex subunit 5 | ENCODES a protein that exhibits actin filament binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN actin filament network formation (ortholog); cell migration (ortholog); lamellipodium organization (ortholog); PARTICIPATES IN insulin responsive facilitative sugar trans porter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Autoimmune Myasthenia Gravis (ortholog); genetic disease (ortholog); FOUND IN endosome (ortholog); glutamatergic synapse (ortholog); growth cone (ortholog) | | | | Naked Mole-Rat | 33 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155245273 | arpc5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626078065 | Arpc5 | actin related protein 2/3 complex subunit 5 | ENCODES a protein that exhibits actin filament binding (ortholog); structural constituent of cytoskeleton (ortholog); INVOLVED IN actin filament network formation (ortholog); Arp2/3 complex-mediated actin nucleation (ortholog); cell migration (ortholog); PARTICIPATES IN insulin responsive facilitati ve sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rab family mediated signaling pathway; ASSOCIATED WITH congenital hypothyroidism (ortholog); Experimental Autoimmune Myasthenia Gravis (ortholog); genetic disease (ortholog); FOUND IN Arp2/3 protein complex (ortholog); endosome (ortholog); glutamatergic synapse (ortholog) | | | | Black Rat | 29 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243208 | arpc5.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155251938 | arpc5.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1308867 | Arpc5l | actin related protein 2/3 complex, subunit 5-like | ENCODES a protein that exhibits actin binding (inferred); INVOLVED IN Arp2/3 complex-mediated actin nucleation (ortholog); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; FOUND IN glutamatergic synapse (ortholog); synapse (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachloro dibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 3 | 43169518 | 43177224 | Rat | 98 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, VALIDATED [RefSeq] |
| 1318888 | ARPC5L | actin related protein 2/3 complex subunit 5 like | Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Located in extracellular exosome and focal adhesion. [provided by Alliance of Genome Resources, Jul 2025] | 9 | 124862130 | 124877733 | Human | 106 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1318889 | Arpc5l | actin related protein 2/3 complex, subunit 5-like | Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune syst em; and integumental system. Orthologous to human ARPC5L (actin related protein 2/3 complex subunit 5 like). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 38895283 | 38905889 | Mouse | 108 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8740142 | Arpc5l | actin related protein 2/3 complex subunit 5 like | INVOLVED IN Arp2/3 complex-mediated actin nucleation (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | NW_004955419 | 3360189 | 3367531 | Chinchilla | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11767746 | ARPC5L | actin related protein 2/3 complex subunit 5 like | ENCODES a protein that exhibits actin binding (inferred); INVOLVED IN Arp2/3 complex-mediated actin nucleation (inferred); regulation of actin filament polymerization (inferred); FOUND IN actin cytoskeleton (inferred); Arp2/3 protein complex (inferred); cytoskeleton (inferred) | 9 | 95989650 | 95998340 | Bonobo | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12294740 | ARPC5L | actin related protein 2/3 complex subunit 5 like | ENCODES a protein that exhibits actin binding (inferred); INVOLVED IN Arp2/3 complex-mediated actin nucleation (inferred); regulation of actin filament polymerization (inferred); FOUND IN actin cytoskeleton (inferred); Arp2/3 protein complex (inferred); cytoskeleton (inferred) | 9 | 58142001 | 58149285 | Dog | 19 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12591091 | Arpc5l | actin related protein 2/3 complex subunit 5 like | ENCODES a protein that exhibits actin binding (inferred); INVOLVED IN Arp2/3 complex-mediated actin nucleation (inferred); regulation of actin filament polymerization (inferred); FOUND IN actin cytoskeleton (inferred); Arp2/3 protein complex (inferred); cytoskeleton (inferred) | NW_004936487 | 13064206 | 13073363 | Squirrel | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13868716 | ARPC5L | actin related protein 2/3 complex subunit 5 like | ENCODES a protein that exhibits actin binding (inferred); INVOLVED IN Arp2/3 complex-mediated actin nucleation (inferred); regulation of actin filament polymerization (inferred); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | | | | Pig | 18 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18404423 | ARPC5L | actin related protein 2/3 complex subunit 5 like | ENCODES a protein that exhibits actin binding (inferred); INVOLVED IN Arp2/3 complex-mediated actin nucleation (inferred); regulation of actin filament polymerization (inferred); FOUND IN actin cytoskeleton (inferred); Arp2/3 protein complex (inferred); cytoskeleton (inferred) | | | | Green Monkey | 14 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18901523 | Arpc5l | actin related protein 2/3 complex subunit 5 like | ENCODES a protein that exhibits actin binding (inferred); INVOLVED IN Arp2/3 complex-mediated actin nucleation (inferred); regulation of actin filament polymerization (inferred); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | | | | Naked Mole-Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866997 | ARPC5L | actin related protein 2/3 complex subunit 5 like | | | | | Green Monkey | | symbol | gene, protein-coding |
| 155244459 | arpc5l | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 625904884 | Arpc5l | actin related protein 2/3 complex subunit 5 like | INVOLVED IN Arp2/3 complex-mediated actin nucleation (ortholog); FOUND IN glutamatergic synapse (ortholog); synapse (ortholog) | | | | Black Rat | 8 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155253242 | arpc5l.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155249317 | arpc5l.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1560362 | Arpc5l-ps1 | actin related protein 2/3 complex, subunit 5-like, pseudogene 1 | ENCODES a pseudogene that exhibits actin binding (inferred); INVOLVED IN Arp2/3 complex-mediated actin nucleation (inferred); regulation of actin filament polymerization (inferred); FOUND IN actin cytoskeleton (inferred); Arp2/3 protein complex (inferred); cytoskeleton (inferred) | 9 | 52755471 | 52756468 | Rat | 11 | symbol , PhenoGen , old_gene_symbol | gene, pseudo, INFERRED [RefSeq] |
| 41401159 | Arpc5l-ps2 | actin related protein 2/3 complex, subunit 5-like, pseudogene 2 | | 17 | 71746771 | 71747531 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 1585449 | Arpc5l-ps3 | actin related protein 2/3 complex, subunit 5-like, pseudogene 3 | | 12 | 27370391 | 27372191 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 40952956 | Arpc5l-ps4 | actin related protein 2/3 complex, subunit 5-like, pseudogene 4 | | 4 | 100879264 | 100880401 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |