ARPC5L (actin related protein 2/3 complex subunit 5 like) - Rat Genome Database

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Gene: ARPC5L (actin related protein 2/3 complex subunit 5 like) Homo sapiens
Analyze
Symbol: ARPC5L
Name: actin related protein 2/3 complex subunit 5 like
RGD ID: 1318888
HGNC Page HGNC:23366
Description: Predicted to enable actin filament binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation and cell migration. Located in extracellular exosome and focal adhesion.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: actin related protein 2/3 complex subunit 5-like; actin related protein 2/3 complex, subunit 5-like; actin-related protein 2/3 complex subunit 5-like protein; ARC16-2; arp2/3 complex 16 kDa subunit 2; MGC3038
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389124,862,130 - 124,877,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9124,862,130 - 124,877,733 (+)EnsemblGRCh38hg38GRCh38
GRCh379127,624,409 - 127,640,012 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369126,671,305 - 126,679,517 (+)NCBINCBI36Build 36hg18NCBI36
Build 349124,711,037 - 124,719,249NCBI
Celera998,279,433 - 98,287,649 (+)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef997,243,876 - 97,252,092 (+)NCBIHuRef
CHM1_19127,780,255 - 127,788,468 (+)NCBICHM1_1
T2T-CHM13v2.09137,060,438 - 137,076,046 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12451597   PMID:12477932   PMID:14702039   PMID:15164053   PMID:15489334   PMID:16169070   PMID:16344560   PMID:17081983   PMID:17207965   PMID:17353931   PMID:17620599   PMID:19056867  
PMID:20458337   PMID:21280222   PMID:21423176   PMID:21653829   PMID:21873635   PMID:21988832   PMID:22658674   PMID:22863883   PMID:22939629   PMID:23376485   PMID:24981860   PMID:26186194  
PMID:26209609   PMID:26344197   PMID:26496610   PMID:26618866   PMID:26655834   PMID:26673895   PMID:26760575   PMID:27609421   PMID:28514442   PMID:29509190   PMID:30021884   PMID:30773093  
PMID:30833792   PMID:31180492   PMID:31527615   PMID:31586073   PMID:31980649   PMID:32296183   PMID:32707033   PMID:32780723   PMID:33144569   PMID:33637726   PMID:33644029   PMID:33947818  
PMID:33961781   PMID:34079125   PMID:34709727   PMID:35013218   PMID:35271311   PMID:35568845   PMID:35676659   PMID:36042349   PMID:36517590   PMID:36526897   PMID:37382373  


Genomics

Comparative Map Data
ARPC5L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389124,862,130 - 124,877,733 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9124,862,130 - 124,877,733 (+)EnsemblGRCh38hg38GRCh38
GRCh379127,624,409 - 127,640,012 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369126,671,305 - 126,679,517 (+)NCBINCBI36Build 36hg18NCBI36
Build 349124,711,037 - 124,719,249NCBI
Celera998,279,433 - 98,287,649 (+)NCBICelera
Cytogenetic Map9q33.3NCBI
HuRef997,243,876 - 97,252,092 (+)NCBIHuRef
CHM1_19127,780,255 - 127,788,468 (+)NCBICHM1_1
T2T-CHM13v2.09137,060,438 - 137,076,046 (+)NCBIT2T-CHM13v2.0
Arpc5l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39238,895,283 - 38,905,889 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl238,895,360 - 38,905,889 (+)EnsemblGRCm39 Ensembl
GRCm38239,008,066 - 39,015,878 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl239,005,348 - 39,015,877 (+)EnsemblGRCm38mm10GRCm38
MGSCv37238,863,659 - 38,871,392 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36238,830,148 - 38,837,881 (+)NCBIMGSCv36mm8
Celera240,733,885 - 40,741,618 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map224.42NCBI
Arpc5l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8343,169,518 - 43,177,224 (+)NCBIGRCr8
mRatBN7.2322,758,710 - 22,767,520 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl945,262,374 - 45,264,366 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl322,759,876 - 22,767,538 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx326,228,380 - 26,236,003 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0334,813,364 - 34,820,987 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0332,626,072 - 32,633,695 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0323,301,455 - 23,309,077 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl323,301,455 - 23,309,072 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0328,523,281 - 28,530,903 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4318,798,930 - 18,801,987 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1318,687,517 - 18,698,957 (+)NCBI
Celera321,193,183 - 21,200,804 (+)NCBICelera
Cytogenetic Map3q12NCBI
Arpc5l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554193,360,189 - 3,367,531 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554193,360,189 - 3,367,531 (-)NCBIChiLan1.0ChiLan1.0
ARPC5L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21114,480,948 - 14,489,327 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1914,483,292 - 14,491,669 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0995,989,650 - 95,998,340 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19124,505,769 - 124,515,396 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9124,505,769 - 124,515,396 (+)Ensemblpanpan1.1panPan2
ARPC5L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1958,142,001 - 58,149,285 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl958,142,389 - 58,149,236 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha957,340,842 - 57,348,123 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0959,062,448 - 59,069,717 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl959,062,836 - 59,069,659 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1957,821,454 - 57,828,735 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0958,137,063 - 58,144,338 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0958,227,991 - 58,235,278 (-)NCBIUU_Cfam_GSD_1.0
Arpc5l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947193,296,420 - 193,304,836 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648713,065,338 - 13,073,053 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648713,064,206 - 13,073,363 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARPC5L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1265,642,260 - 265,654,018 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11265,645,800 - 265,653,513 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21299,468,496 - 299,479,052 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ARPC5L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11213,268,223 - 13,284,590 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1213,268,025 - 13,283,515 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660792,823,995 - 2,832,582 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arpc5l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476010,322,034 - 10,329,616 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476010,322,034 - 10,333,234 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ARPC5L
5 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121112395-138075224)x3 copy number gain See cases [RCV000051009] Chr9:121112395..138075224 [GRCh38]
Chr9:123874673..140969676 [GRCh37]
Chr9:122914494..140089497 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:122792658-138124532)x3 copy number gain See cases [RCV000051040] Chr9:122792658..138124532 [GRCh38]
Chr9:125554937..141018984 [GRCh37]
Chr9:124594758..140138805 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121586837-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053776]|See cases [RCV000053776] Chr9:121586837..138179445 [GRCh38]
Chr9:124349116..141073897 [GRCh37]
Chr9:123388937..140193718 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q33.2-34.3(chr9:121073102-138179445)x3 copy number gain See cases [RCV000134920] Chr9:121073102..138179445 [GRCh38]
Chr9:123835380..141073897 [GRCh37]
Chr9:122875201..140193718 [NCBI36]
Chr9:9q33.2-34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic|conflicting data from submitters
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q33.2-33.3(chr9:123095598-126693843)x1 copy number loss See cases [RCV000141589] Chr9:123095598..126693843 [GRCh38]
Chr9:125857877..129456122 [GRCh37]
Chr9:124897698..128495943 [NCBI36]
Chr9:9q33.2-33.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain not specified [RCV003986800] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q33.2-34.3(chr9:124642754-141146461)x3 copy number gain See cases [RCV000448784] Chr9:124642754..141146461 [GRCh37]
Chr9:9q33.2-34.3		 pathogenic
NM_030978.3(ARPC5L):c.176C>A (p.Ala59Glu) single nucleotide variant Inborn genetic diseases [RCV003255657] Chr9:124873718 [GRCh38]
Chr9:127635997 [GRCh37]
Chr9:9q33.3		 uncertain significance
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3		 likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:353349-141020389) copy number gain not specified [RCV002053823] Chr9:353349..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q32-34.11(chr9:116422275-131713233) copy number gain not specified [RCV002052831] Chr9:116422275..131713233 [GRCh37]
Chr9:9q32-34.11		 pathogenic
GRCh37/hg19 9p24.3-q34.11(chr9:203861-131603223)x3 copy number gain See cases [RCV002292402] Chr9:203861..131603223 [GRCh37]
Chr9:9p24.3-q34.11		 pathogenic
GRCh37/hg19 9q33.2-33.3(chr9:124018736-129995568)x1 copy number loss not provided [RCV002474540] Chr9:124018736..129995568 [GRCh37]
Chr9:9q33.2-33.3		 pathogenic
NM_030978.3(ARPC5L):c.23C>G (p.Ser8Trp) single nucleotide variant Inborn genetic diseases [RCV002849652] Chr9:124869313 [GRCh38]
Chr9:127631592 [GRCh37]
Chr9:9q33.3		 uncertain significance
NM_030978.3(ARPC5L):c.109C>G (p.Pro37Ala) single nucleotide variant Inborn genetic diseases [RCV003263481] Chr9:124869399 [GRCh38]
Chr9:127631678 [GRCh37]
Chr9:9q33.3		 uncertain significance
NM_030978.3(ARPC5L):c.313G>A (p.Val105Ile) single nucleotide variant Inborn genetic diseases [RCV003342249] Chr9:124875065 [GRCh38]
Chr9:127637344 [GRCh37]
Chr9:9q33.3		 likely benign
GRCh37/hg19 9q33.3(chr9:127471268-127701091)x3 copy number gain not specified [RCV003986826] Chr9:127471268..127701091 [GRCh37]
Chr9:9q33.3		 uncertain significance
NM_030978.3(ARPC5L):c.310G>A (p.Gly104Ser) single nucleotide variant Inborn genetic diseases [RCV003357410] Chr9:124875062 [GRCh38]
Chr9:127637341 [GRCh37]
Chr9:9q33.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:702
Count of miRNA genes:299
Interacting mature miRNAs:337
Transcripts:ENST00000259477, ENST00000353214, ENST00000465124
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH1557  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379127,639,654 - 127,639,798UniSTSGRCh37
Build 369126,679,475 - 126,679,619RGDNCBI36
Celera998,287,607 - 98,287,751RGD
Cytogenetic Map9q33.3UniSTS
HuRef997,252,050 - 97,252,194UniSTS
GeneMap99-GB4 RH Map9385.51UniSTS
RH41807  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379127,639,407 - 127,639,607UniSTSGRCh37
Build 369126,679,228 - 126,679,428RGDNCBI36
Celera998,287,360 - 98,287,560RGD
Cytogenetic Map9q33.3UniSTS
HuRef997,251,803 - 97,252,003UniSTS
GeneMap99-GB4 RH Map9383.29UniSTS
SGC32156  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379127,639,535 - 127,639,684UniSTSGRCh37
GRCh37176,258,799 - 6,258,947UniSTSGRCh37
Build 369126,679,356 - 126,679,505RGDNCBI36
Celera998,287,488 - 98,287,637RGD
Celera176,279,333 - 6,279,481UniSTS
Cytogenetic Map9q33.3UniSTS
HuRef176,153,851 - 6,153,999UniSTS
HuRef997,251,931 - 97,252,080UniSTS
GeneMap99-GB4 RH Map9385.71UniSTS
Whitehead-RH Map9462.3UniSTS
G19389  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37176,258,799 - 6,258,930UniSTSGRCh37
GRCh379127,639,535 - 127,639,667UniSTSGRCh37
Build 369126,679,356 - 126,679,488RGDNCBI36
Celera998,287,488 - 98,287,620RGD
Celera176,279,333 - 6,279,464UniSTS
Cytogenetic Map9q33.3UniSTS
HuRef997,251,931 - 97,252,063UniSTS
HuRef176,153,851 - 6,153,982UniSTS
WI-20843  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379127,639,420 - 127,639,667UniSTSGRCh37
Build 369126,679,241 - 126,679,488RGDNCBI36
Celera998,287,373 - 98,287,620RGD
Cytogenetic Map9q33.3UniSTS
HuRef997,251,816 - 97,252,063UniSTS
GeneMap99-GB4 RH Map9383.29UniSTS
Whitehead-RH Map9461.2UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2401 2442 1653 554 1595 398 4345 2032 3418 385 1414 1606 170 1203 2778 3
Low 34 545 73 69 353 66 12 162 309 33 40 3 4 1 10 1 1
Below cutoff 3 1 3 3 7 1 4 2 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_030978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011519067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047423938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047423939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047423941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054363918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001746387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007061359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA731112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF087842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK023881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK056174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL354928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX537659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA361505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ901034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000259477   ⟹   ENSP00000259477
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9124,869,205 - 124,877,717 (+)Ensembl
RefSeq Acc Id: ENST00000353214   ⟹   ENSP00000345361
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9124,862,130 - 124,877,733 (+)Ensembl
RefSeq Acc Id: ENST00000465124
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9124,872,589 - 124,877,401 (+)Ensembl
RefSeq Acc Id: NM_030978   ⟹   NP_112240
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389124,862,130 - 124,877,733 (+)NCBI
GRCh379127,626,267 - 127,640,012 (+)NCBI
Build 369126,671,305 - 126,679,517 (+)NCBI Archive
Celera998,279,433 - 98,287,649 (+)RGD
HuRef997,243,876 - 97,252,092 (+)RGD
CHM1_19127,773,169 - 127,788,784 (+)NCBI
T2T-CHM13v2.09137,060,438 - 137,076,046 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047423938   ⟹   XP_047279894
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389124,869,194 - 124,873,684 (+)NCBI
RefSeq Acc Id: XM_047423939   ⟹   XP_047279895
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389124,869,194 - 124,873,701 (+)NCBI
RefSeq Acc Id: XM_047423941   ⟹   XP_047279897
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389124,869,194 - 124,877,733 (+)NCBI
RefSeq Acc Id: XM_054363918   ⟹   XP_054219893
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.09137,060,438 - 137,071,993 (+)NCBI
RefSeq Acc Id: XR_007061359
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389124,869,194 - 124,873,749 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_112240   ⟸   NM_030978
- UniProtKB: Q7Z523 (UniProtKB/Swiss-Prot),   Q9BPX5 (UniProtKB/Swiss-Prot),   A0A024R897 (UniProtKB/TrEMBL),   B3KPC7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000259477   ⟸   ENST00000259477
RefSeq Acc Id: ENSP00000345361   ⟸   ENST00000353214
RefSeq Acc Id: XP_047279897   ⟸   XM_047423941
- Peptide Label: isoform X3
RefSeq Acc Id: XP_047279895   ⟸   XM_047423939
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047279894   ⟸   XM_047423938
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054219893   ⟸   XM_054363918
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9BPX5-F1-model_v2 AlphaFold Q9BPX5 1-153 view protein structure

Promoters
RGD ID:7216125
Promoter ID:EPDNEW_H13809
Type:initiation region
Name:ARPC5L_1
Description:actin related protein 2/3 complex subunit 5 like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389124,869,194 - 124,869,254EPDNEW
RGD ID:6807251
Promoter ID:HG_KWN:64907
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000353214,   ENST00000373570,   NM_007209,   OTTHUMT00000054036,   OTTHUMT00000054037,   OTTHUMT00000054038,   OTTHUMT00000054039
Position:
Human AssemblyChrPosition (strand)Source
Build 369126,662,651 - 126,664,242 (+)MPROMDB
RGD ID:6807205
Promoter ID:HG_KWN:64908
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:UC004BOZ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 369126,665,621 - 126,666,121 (+)MPROMDB
RGD ID:6807243
Promoter ID:HG_KWN:64909
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000054040
Position:
Human AssemblyChrPosition (strand)Source
Build 369126,670,626 - 126,671,292 (+)MPROMDB
RGD ID:6807244
Promoter ID:HG_KWN:64910
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000054042
Position:
Human AssemblyChrPosition (strand)Source
Build 369126,674,046 - 126,675,842 (+)MPROMDB
RGD ID:6813575
Promoter ID:HG_ACW:82372
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ARPC5L.GAPR07-UNSPLICED
Position:
Human AssemblyChrPosition (strand)Source
Build 369126,677,726 - 126,679,377 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:23366 AgrOrtholog
COSMIC ARPC5L COSMIC
Ensembl Genes ENSG00000136950 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000259477.6 UniProtKB/Swiss-Prot
  ENST00000353214 ENTREZGENE
  ENST00000353214.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000136950 GTEx
HGNC ID HGNC:23366 ENTREZGENE
Human Proteome Map ARPC5L Human Proteome Map
InterPro ARPC5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARPC5_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:81873 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81873 ENTREZGENE
PANTHER PTHR12644 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12644:SF2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam P16-Arc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA134991012 PharmGKB
PIRSF p16-ARC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF69103 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024R897 ENTREZGENE, UniProtKB/TrEMBL
  ARP5L_HUMAN UniProtKB/Swiss-Prot
  B3KPC7 ENTREZGENE, UniProtKB/TrEMBL
  Q7Z523 ENTREZGENE
  Q9BPX5 ENTREZGENE
UniProt Secondary Q7Z523 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-21 ARPC5L  actin related protein 2/3 complex subunit 5 like    actin related protein 2/3 complex subunit 5-like  Symbol and/or name change 5135510 APPROVED
2015-11-10 ARPC5L  actin related protein 2/3 complex subunit 5-like    actin related protein 2/3 complex, subunit 5-like  Symbol and/or name change 5135510 APPROVED