| 2125 | Apeh | acylaminoacyl-peptide hydrolase | ENCODES a protein that exhibits identical protein binding (ortholog); omega peptidase activity (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); proteolysis (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibe nzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil | 8 | 117652390 | 117661502 | Rat | 127 | symbol , PhenoGen , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 10170 | Apeh | acylpeptide hydrolase | Predicted to enable identical protein binding activity; omega peptidase activity; and serine-type endopeptidase activity. Predicted to be involved in amyloid-beta metabolic process and proteolysis. Predicted to be located in cytosol and nuclear membrane. Is expressed in dorsal root ganglion and live r lobe. Orthologous to human APEH (acylaminoacyl-peptide hydrolase). [provided by Alliance of Genome Resources, Jul 2025] | 9 | 107962613 | 107971736 | Mouse | 135 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 735668 | APEH | acylaminoacyl-peptide hydrolase | This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene i s located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma. [provided by RefSeq, Jul 2008] | 3 | 49673117 | 49683971 | Human | 131 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8717346 | Apeh | acylaminoacyl-peptide hydrolase | ENCODES a protein that exhibits identical protein binding (ortholog); omega peptidase activity (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); proteolysis (ortholog); FOUND IN cytosol (ortholog) | NW_004955532 | 1580473 | 1590274 | Chinchilla | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11765175 | APEH | acylaminoacyl-peptide hydrolase | ENCODES a protein that exhibits hydrolase activity (inferred); identical protein binding (inferred); omega peptidase activity (inferred); INVOLVED IN amyloid-beta metabolic process (inferred); proteolysis (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred) | 3 | 49606294 | 49615896 | Bonobo | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12118545 | APEH | acylaminoacyl-peptide hydrolase | ENCODES a protein that exhibits hydrolase activity (inferred); identical protein binding (inferred); omega peptidase activity (inferred); INVOLVED IN amyloid-beta metabolic process (inferred); proteolysis (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred) | 20 | 39587316 | 39596324 | Dog | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12534389 | Apeh | acylaminoacyl-peptide hydrolase | ENCODES a protein that exhibits hydrolase activity (inferred); identical protein binding (inferred); omega peptidase activity (inferred); INVOLVED IN amyloid-beta metabolic process (inferred); proteolysis (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred) | NW_004936529 | 1289810 | 1298798 | Squirrel | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20867121 | APEH | acylaminoacyl-peptide hydrolase | | | | | Green Monkey | | symbol | gene, protein-coding |
| 626067444 | Apeh | acylaminoacyl-peptide hydrolase | ENCODES a protein that exhibits identical protein binding (ortholog); omega peptidase activity (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN amyloid-beta metabolic process (ortholog); proteolysis (ortholog); FOUND IN cytosol (ortholog) | | | | Black Rat | 10 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18932573 | Apeh | acylaminoacyl-peptide hydrolase | ENCODES a protein that exhibits hydrolase activity (inferred); identical protein binding (inferred); omega peptidase activity (inferred); INVOLVED IN amyloid-beta metabolic process (inferred); proteolysis (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Naked Mole-Rat | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155247123 | apeh | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13917174 | APEH | acylaminoacyl-peptide hydrolase | ENCODES a protein that exhibits hydrolase activity (inferred); identical protein binding (inferred); omega peptidase activity (inferred); INVOLVED IN amyloid-beta metabolic process (inferred); proteolysis (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred); INTERACTS WITH chlorpyrifos-meth yl; dichlorvos; diisopropyl fluorophosphate | | | | Pig | 21 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18524352 | APEH | acylaminoacyl-peptide hydrolase | ENCODES a protein that exhibits hydrolase activity (inferred); identical protein binding (inferred); omega peptidase activity (inferred); INVOLVED IN amyloid-beta metabolic process (inferred); proteolysis (inferred); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 18 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155235781 | apeh.L | | | | | | African Clawed Frog | | symbol | gene, null |
