Apeh (acylpeptide hydrolase) - Rat Genome Database
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Gene: Apeh (acylpeptide hydrolase) Mus musculus
Analyze
Symbol: Apeh
Name: acylpeptide hydrolase
RGD ID: 10170
MGI Page MGI
Description: Predicted to have identical protein binding activity; omega peptidase activity; and serine-type endopeptidase activity. Predicted to be involved in amyloid-beta metabolic process and proteolysis. Predicted to localize to cytosol and nuclear membrane. Is expressed in dorsal root ganglion and liver lobe. Orthologous to human APEH (acylaminoacyl-peptide hydrolase); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AARE; acyl-peptide hydrolase; acylamino-acid-releasing enzyme; acylaminoacyl-peptidase; APH; MGC38101; N-acylaminoacyl peptide hydrolase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,962,612 - 107,971,736 (-)NCBIGRCm39mm39
GRCm389108,085,413 - 108,094,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,085,413 - 108,094,606 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,987,745 - 107,996,811 (-)NCBIGRCm37mm9NCBIm37
MGSCv369107,943,514 - 107,952,552 (-)NCBImm8
Celera9107,695,183 - 107,704,249 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map959.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:1832957   PMID:1889815   PMID:8641130   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11130978   PMID:11217851   PMID:12477932   PMID:14610273  
PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:21267068   PMID:21873635   PMID:30834655   PMID:32325033  


Genomics

Comparative Map Data
Apeh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,962,612 - 107,971,736 (-)NCBIGRCm39mm39
GRCm389108,085,413 - 108,094,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,085,413 - 108,094,606 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,987,745 - 107,996,811 (-)NCBIGRCm37mm9NCBIm37
MGSCv369107,943,514 - 107,952,552 (-)NCBImm8
Celera9107,695,183 - 107,704,249 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map959.07NCBI
APEH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,674,014 - 49,683,971 (+)EnsemblGRCh38hg38GRCh38
GRCh38349,673,102 - 49,683,971 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,711,427 - 49,720,936 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,686,439 - 49,695,938 (+)NCBINCBI36hg18NCBI36
Build 34349,686,438 - 49,695,937NCBI
Celera349,676,127 - 49,685,626 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,770,415 - 49,779,914 (+)NCBIHuRef
CHM1_1349,663,491 - 49,672,990 (+)NCBICHM1_1
Apeh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08116,862,664 - 116,871,776 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,862,625 - 116,872,215 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,216,745 - 116,225,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,353,151 - 113,362,263 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18113,372,606 - 113,381,718 (-)NCBI
Celera8108,078,004 - 108,087,116 (-)NCBICelera
Cytogenetic Map8q32NCBI
RH 3.4 Map81116.3RGD
Apeh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,580,553 - 1,590,138 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,580,473 - 1,590,274 (+)NCBIChiLan1.0ChiLan1.0
APEH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,843,968 - 50,853,516 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,843,220 - 50,853,516 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0349,606,294 - 49,615,896 (+)NCBIMhudiblu_PPA_v0panPan3
APEH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,587,279 - 39,596,228 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,587,316 - 39,596,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Apeh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,289,810 - 1,298,798 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APEH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,205,609 - 32,214,523 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,205,863 - 32,214,517 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,385,067 - 35,393,717 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APEH
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,067,966 - 11,078,258 (+)NCBI
Apeh
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,601,792 - 3,612,048 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
1301297Lcho1_mliver cholesterol 1 (mouse)Not determined9101060861124595110Mouse
1357627Tgq2_mtriglyceride QTL 2 (mouse)Not determined9102000187124595110Mouse
1357648Obq18_mobesity QTL 18 (mouse)Not determined9102000187124595110Mouse
1301789Pbwg4_mpostnatal body weight growth 4 (mouse)Not determined9103289445124595110Mouse
10412290Pvacm1l_mplasma vascular cell adhesion molecule 1 levels (mouse)Not determined9103289445124595110Mouse
12879896Berr3_mberghei resistance locus 3 (mouse)9103289445124595110Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:155
Count of miRNA genes:133
Interacting mature miRNAs:149
Transcripts:ENSMUST00000081309
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_146226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006511723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244344 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC137678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI845932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK204166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB737329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC034199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ134183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000081309   ⟹   ENSMUSP00000080058
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,085,413 - 108,094,441 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191754
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,086,148 - 108,088,520 (-)Ensembl
RefSeq Acc Id: ENSMUST00000191985   ⟹   ENSMUSP00000142150
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,092,623 - 108,094,479 (-)Ensembl
RefSeq Acc Id: ENSMUST00000192278
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,092,344 - 108,094,020 (-)Ensembl
RefSeq Acc Id: ENSMUST00000192916
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,085,414 - 108,086,028 (-)Ensembl
RefSeq Acc Id: ENSMUST00000193254   ⟹   ENSMUSP00000141856
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,085,413 - 108,094,606 (-)Ensembl
RefSeq Acc Id: ENSMUST00000194014
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,085,914 - 108,086,468 (-)Ensembl
RefSeq Acc Id: ENSMUST00000194083
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,086,776 - 108,094,476 (-)Ensembl
RefSeq Acc Id: ENSMUST00000194915
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl9108,085,414 - 108,094,466 (-)Ensembl
RefSeq Acc Id: NM_146226   ⟹   NP_666338
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,962,613 - 107,971,679 (-)NCBI
GRCm389108,085,414 - 108,094,480 (-)NCBI
MGSCv379107,987,745 - 107,996,811 (-)RGD
Celera9107,695,183 - 107,704,249 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006511723   ⟹   XP_006511786
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,962,612 - 107,971,683 (-)NCBI
GRCm389108,085,414 - 108,094,490 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244343   ⟹   XP_030100203
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,962,612 - 107,971,683 (-)NCBI
GRCm389108,085,414 - 108,094,484 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244344   ⟹   XP_030100204
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm399107,962,613 - 107,971,736 (-)NCBI
GRCm389108,085,413 - 108,094,470 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_666338   ⟸   NM_146226
- UniProtKB: Q8R146 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006511786   ⟸   XM_006511723
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_030100204   ⟸   XM_030244344
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030100203   ⟸   XM_030244343
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000142150   ⟸   ENSMUST00000191985
RefSeq Acc Id: ENSMUSP00000080058   ⟸   ENSMUST00000081309
RefSeq Acc Id: ENSMUSP00000141856   ⟸   ENSMUST00000193254
Protein Domains
Peptidase_S9

Promoters
RGD ID:6844165
Promoter ID:MM_KWN:58776
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:UC009ROS.1,   UC009ROT.1,   UC009ROU.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv369107,996,681 - 107,997,181 (-)MPROMDB
RGD ID:8670864
Promoter ID:EPDNEW_M13463
Type:multiple initiation site
Name:Apeh_1
Description:Mus musculus acylpeptide hydrolase , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm389108,094,481 - 108,094,541EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88041 AgrOrtholog
Ensembl Genes ENSMUSG00000032590 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000080058 UniProtKB/TrEMBL
  ENSMUSP00000141856 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000142150 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000081309 UniProtKB/TrEMBL
  ENSMUST00000191985 UniProtKB/TrEMBL
  ENSMUST00000193254 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_S9_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:235606 UniProtKB/Swiss-Prot
MGD MGI:88041 ENTREZGENE
NCBI Gene 235606 ENTREZGENE
Pfam Peptidase_S9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Apeh PhenoGen
PROSITE PRO_ENDOPEP_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.219639 ENTREZGENE
UniProt A0A0A6YXV0_MOUSE UniProtKB/TrEMBL
  A0A0R4J107_MOUSE UniProtKB/TrEMBL
  APEH_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3X9I2 UniProtKB/Swiss-Prot
  Q8K029 UniProtKB/Swiss-Prot
  Q8R0M9 UniProtKB/Swiss-Prot