APEH (acylaminoacyl-peptide hydrolase) - Rat Genome Database

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Gene: APEH (acylaminoacyl-peptide hydrolase) Pan paniscus
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Symbol: APEH
Name: acylaminoacyl-peptide hydrolase
RGD ID: 11765175
Description: ENCODES a protein that exhibits hydrolase activity (inferred); identical protein binding (inferred); omega peptidase activity (inferred); INVOLVED IN amyloid-beta metabolic process (inferred); proteolysis (inferred); ASSOCIATED WITH Aicardi-Goutieres Syndrome 1 (ortholog); developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nuclear membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: acylamino-acid-releasing enzyme; N-acylaminoacyl-peptide hydrolase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,659,511 - 49,670,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,665,230 - 49,675,114 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,606,294 - 49,615,896 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,843,968 - 50,853,516 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,843,220 - 50,853,516 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
APEH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,659,511 - 49,670,341 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,665,230 - 49,675,114 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,606,294 - 49,615,896 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,843,968 - 50,853,516 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,843,220 - 50,853,516 (+)Ensemblpanpan1.1panPan2
APEH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,673,117 - 49,683,971 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,674,014 - 49,683,971 (+)EnsemblGRCh38hg38GRCh38
GRCh37349,711,784 - 49,721,404 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,686,439 - 49,695,938 (+)NCBINCBI36Build 36hg18NCBI36
Build 34349,686,438 - 49,695,937NCBI
Celera349,676,127 - 49,685,626 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,770,415 - 49,779,914 (+)NCBIHuRef
CHM1_1349,663,491 - 49,672,990 (+)NCBICHM1_1
T2T-CHM13v2.0349,702,408 - 49,713,255 (+)NCBIT2T-CHM13v2.0
Apeh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,962,613 - 107,971,736 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,962,612 - 107,971,805 (-)EnsemblGRCm39 Ensembl
GRCm389108,085,413 - 108,094,490 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,085,413 - 108,094,606 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,987,745 - 107,996,811 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,943,514 - 107,952,552 (-)NCBIMGSCv36mm8
Celera9107,695,183 - 107,704,249 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map959.07NCBI
Apeh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,652,390 - 117,661,502 (-)NCBIGRCr8
mRatBN7.28108,773,791 - 108,782,903 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,773,794 - 108,782,933 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,400,007 - 114,409,117 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,599,331 - 112,608,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,441,972 - 110,451,082 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,862,664 - 116,871,776 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,862,625 - 116,872,215 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,216,745 - 116,225,857 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,353,151 - 113,362,263 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,372,606 - 113,381,718 (-)NCBI
Celera8108,078,004 - 108,087,116 (-)NCBICelera
RH 3.4 Map81116.3RGD
Cytogenetic Map8q32NCBI
Apeh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,580,553 - 1,590,138 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,580,473 - 1,590,274 (+)NCBIChiLan1.0ChiLan1.0
APEH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,587,316 - 39,596,324 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,587,279 - 39,596,228 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,508,241 - 39,517,291 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,944,841 - 39,953,890 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,944,843 - 39,953,810 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,311,923 - 39,320,973 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,715,279 - 39,724,328 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,995,110 - 40,004,158 (-)NCBIUU_Cfam_GSD_1.0
Apeh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,529,248 - 64,538,312 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,289,827 - 1,298,798 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,289,810 - 1,298,798 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APEH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,205,609 - 32,214,518 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,205,863 - 32,214,517 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,385,067 - 35,393,717 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APEH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,067,966 - 11,078,258 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041155,922,305 - 155,931,881 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apeh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247303,601,714 - 3,612,048 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247303,601,792 - 3,612,048 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000059554   ⟹   ENSPPAP00000036661
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl350,843,220 - 50,853,354 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059558   ⟹   ENSPPAP00000036665
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl350,843,220 - 50,845,720 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059562   ⟹   ENSPPAP00000036669
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl350,843,968 - 50,853,516 (+)Ensembl
RefSeq Acc Id: XM_003818852   ⟹   XP_003818900
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,660,634 - 49,670,341 (+)NCBI
NHGRI_mPanPan1349,665,230 - 49,675,114 (+)NCBI
Mhudiblu_PPA_v0349,606,298 - 49,615,896 (+)NCBI
PanPan1.1350,843,968 - 50,853,516 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034956475   ⟹   XP_034812366
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,660,898 - 49,670,341 (+)NCBI
NHGRI_mPanPan1349,665,671 - 49,675,114 (+)NCBI
Mhudiblu_PPA_v0349,606,294 - 49,615,896 (+)NCBI
RefSeq Acc Id: XM_034956476   ⟹   XP_034812367
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,661,337 - 49,670,341 (+)NCBI
NHGRI_mPanPan1349,666,110 - 49,675,114 (+)NCBI
Mhudiblu_PPA_v0349,606,880 - 49,615,896 (+)NCBI
RefSeq Acc Id: XM_034956477   ⟹   XP_034812368
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,661,110 - 49,670,341 (+)NCBI
NHGRI_mPanPan1349,665,886 - 49,675,114 (+)NCBI
Mhudiblu_PPA_v0349,606,295 - 49,615,896 (+)NCBI
RefSeq Acc Id: XM_063602365   ⟹   XP_063458435
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,659,511 - 49,670,341 (+)NCBI
RefSeq Acc Id: XP_003818900   ⟸   XM_003818852
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C4F1 (UniProtKB/TrEMBL),   A0A2R9C3X3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034812366   ⟸   XM_034956475
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C3X3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034812368   ⟸   XM_034956477
- Peptide Label: isoform X5
- UniProtKB: A0A2R9C3X3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034812367   ⟸   XM_034956476
- Peptide Label: isoform X4
- UniProtKB: A0A2R9C3X3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000036661   ⟸   ENSPPAT00000059554
RefSeq Acc Id: ENSPPAP00000036665   ⟸   ENSPPAT00000059558
RefSeq Acc Id: ENSPPAP00000036669   ⟸   ENSPPAT00000059562
RefSeq Acc Id: XP_063458435   ⟸   XM_063602365
- Peptide Label: isoform X1

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041077 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059554.1 UniProtKB/TrEMBL
  ENSPPAT00000059558.1 UniProtKB/TrEMBL
  ENSPPAT00000059562.1 UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  3.40.50.1820 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  AARE_N UniProtKB/TrEMBL
  AB_hydrolase UniProtKB/TrEMBL
  Pept_S9_AS UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/TrEMBL
KEGG Report pps:100985786 UniProtKB/TrEMBL
NCBI Gene APEH ENTREZGENE
PANTHER ACYLAMINO-ACID-RELEASING ENZYME UniProtKB/TrEMBL
  SERINE PEPTIDASE S9 FAMILY MEMBER UniProtKB/TrEMBL
Pfam APEH_N UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/TrEMBL
PROSITE PRO_ENDOPEP_SER UniProtKB/TrEMBL
Superfamily-SCOP Peptidase/esterase 'gauge' domain UniProtKB/TrEMBL
  SSF53474 UniProtKB/TrEMBL
UniProt A0A2R9C3X3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C405_PANPA UniProtKB/TrEMBL
  A0A2R9C4F1 ENTREZGENE, UniProtKB/TrEMBL