| 619930 | Abcb11 | ATP binding cassette subfamily B member 11 | ENCODES a protein that exhibits ABC-type bile acid transporter activity; ABC-type xenobiotic transporter activity; bile acid transmembrane transporter activity; INVOLVED IN bile acid and bile salt transport; bile acid metabolic process; canalicular bile acid transport; PARTICIPATES IN statin pharmac okinetics pathway; bile acid transport pathway; ASSOCIATED WITH alcoholic hepatitis; cholestasis; Endotoxemia; FOUND IN apical plasma membrane; basolateral plasma membrane; endosome; INTERACTS WITH (-)-epigallocatechin 3-gallate; (S)-colchicine; 1,3,5-trinitro-1,3,5-triazinane | 3 | 74424620 | 74520646 | Rat | 882 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 730944 | ABCB11 | ATP binding cassette subfamily B member 11 | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, G CN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008] | 2 | 168915390 | 169031324 | Human | 1163 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 730945 | Abcb11 | ATP-binding cassette, sub-family B member 11 | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, G CN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt transporter in humans and mice. Mutations in the human gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008] | 2 | 69068626 | 69172960 | Mouse | 911 | symbol , PhenoGen | gene, protein-coding, REVIEWED [RefSeq] |
| 8883561 | Abcb11 | ATP binding cassette subfamily B member 11 | ENCODES a protein that exhibits ABC-type bile acid transporter activity (ortholog); ABC-type xenobiotic transporter activity (ortholog); bile acid transmembrane transporter activity (ortholog); INVOLVED IN bile acid and bile salt transport (ortholog); bile acid metabolic process (ortholog); canalicu lar bile acid transport (ortholog); PARTICIPATES IN statin pharmacokinetics pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); benign recurrent intrahepatic cholestasis 2 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog) | NW_004955449 | 5412958 | 5511629 | Chinchilla | 119 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11986627 | ABCB11 | ATP binding cassette subfamily B member 11 | ENCODES a protein that exhibits canalicular bile acid transmembrane transporter activity (ortholog); carbohydrate transmembrane transporter activity (ortholog); INVOLVED IN canalicular bile acid transport (ortholog); cellular response to xenobiotic stimulus (ortholog); response to estrogen (ortholog ); PARTICIPATES IN statin pharmacokinetics pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); benign recurrent intrahepatic cholestasis 2 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); endosome (ortholog) | 2B | 56199434 | 56311773 | Bonobo | 97 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12284259 | ABCB11 | ATP binding cassette subfamily B member 11 | ENCODES a protein that exhibits ABC-type bile acid transporter activity; bile acid transmembrane transporter activity; ABC-type xenobiotic transporter activity (ortholog); INVOLVED IN bile acid and bile salt transport; canalicular bile acid transport; bile acid metabolic process (ortholog); PARTICIP ATES IN statin pharmacokinetics pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); benign recurrent intrahepatic cholestasis 2 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN plasma membrane; apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); INTERACTS WITH blebbistatin | 36 | 13742895 | 13835312 | Dog | 114 | symbol , old_gene_symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12567501 | Abcb11 | ATP binding cassette subfamily B member 11 | ENCODES a protein that exhibits canalicular bile acid transmembrane transporter activity (ortholog); carbohydrate transmembrane transporter activity (ortholog); INVOLVED IN canalicular bile acid transport (ortholog); cellular response to xenobiotic stimulus (ortholog); response to estrogen (ortholog ); PARTICIPATES IN statin pharmacokinetics pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); benign recurrent intrahepatic cholestasis 2 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); endosome (ortholog) | NW_004936469 | 10521576 | 10599005 | Squirrel | 96 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626187303 | abcb11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626182908 | abcb11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18444742 | ABCB11 | ATP binding cassette subfamily B member 11 | ENCODES a protein that exhibits canalicular bile acid transmembrane transporter activity (ortholog); carbohydrate transmembrane transporter activity (ortholog); INVOLVED IN canalicular bile acid transport (ortholog); cellular response to xenobiotic stimulus (ortholog); response to estrogen (ortholog ); PARTICIPATES IN statin pharmacokinetics pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); benign recurrent intrahepatic cholestasis 2 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); endosome (ortholog) | | | | Green Monkey | 96 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625907158 | Abcb11 | ATP binding cassette subfamily B member 11 | ENCODES a protein that exhibits ABC-type bile acid transporter activity (ortholog); ABC-type xenobiotic transporter activity (ortholog); bile acid transmembrane transporter activity (ortholog); INVOLVED IN bile acid and bile salt transport (ortholog); bile acid metabolic process (ortholog); canalicu lar bile acid transport (ortholog); PARTICIPATES IN statin pharmacokinetics pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); benign recurrent intrahepatic cholestasis 2 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog) | | | | Black Rat | 118 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14259888 | ABCB11 | ATP binding cassette subfamily B member 11 | ENCODES a protein that exhibits canalicular bile acid transmembrane transporter activity (ortholog); carbohydrate transmembrane transporter activity (ortholog); INVOLVED IN canalicular bile acid transport (ortholog); cellular response to xenobiotic stimulus (ortholog); response to estrogen (ortholog ); PARTICIPATES IN statin pharmacokinetics pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); benign recurrent intrahepatic cholestasis 2 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); endosome (ortholog); INTERACTS WITH taurocholic acid | | | | Pig | 102 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626177549 | abcb11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626183679 | abcb11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626187837 | abcb11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626179614 | abcb11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626174078 | abcb11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 626176304 | abcb11 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18927922 | Abcb11 | ATP binding cassette subfamily B member 11 | ENCODES a protein that exhibits ABC-type bile acid transporter activity (ortholog); ABC-type xenobiotic transporter activity (ortholog); canalicular bile acid transmembrane transporter activity (ortholog); INVOLVED IN bile acid and bile salt transport (ortholog); bile acid metabolic process (ortholo g); canalicular bile acid transport (ortholog); PARTICIPATES IN statin pharmacokinetics pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); benign recurrent intrahepatic cholestasis 2 (ortholog); Chemical and Drug Induced Liver Injury (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog) | | | | Naked Mole-Rat | 113 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 285209152 | abcb11.2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 596933366 | abcb11.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596933508 | abcb11.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934617 | abcb11.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 329332817 | abcb11.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 596934975 | abcb11.2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 285209051 | abcb11.2.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 12904731 | Abcb11em1Sage | ATP binding cassette subfamily B member 11;ZFN induced mutant 1, Sage | This ZFN induced allele contains 8-bp deletion within Abcb11 gene. The homozygous knockout rats display total loss of protein via Western blot. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
