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Strain Registration

Strain: PVG/OlaHsd

Symbol: PVG/OlaHsd
Strain: PVG
Substrain: OlaHsd
RGD ID: 629486
Citation ID: RRID:RGD_629486
Ontology ID: RS:0000645
Type: inbred
Available Source: Envigo
Description: black hooded, from A.R.C. Cambridge, United Kingdom; to Olac, United Kingdom, in 1979; to Harlan, United States, in 1992
Coat Color: Black-hooded
Last Known Status: Cryorecovery





References

References - curated
# Reference Title Reference Citation
1. Spectrum of aerobic endurance running performance in eleven inbred strains of rats. Barbato JC, etal., J Appl Physiol 1998 Aug;85(2):530-6.
2. Genetic characterization of inbred strains of the rat (Rattus norvegicus). Bender K, etal., J Exp Anim Sci 1994 Aug;36(4-5):151-65.
3. Phenotypic variation in sensorimotor performance among eleven inbred rat strains. Biesiadecki BJ, etal., Am J Physiol 1999 May;276(5 Pt 2):R1383-9.
4. Sequencing and chromosomal localization of Fabp6 and an intronless Fabp6 segment in the rat. Bonne A, etal., Mol Biol Rep 2003 Sep;30(3):173-6.
5. Single Nucleotide Polymorphisms associated with rat expressed sequences. Guryev V, etal., Genome Res. 2004 Jul;14(7):1438-43.
6. Polymorphisms of the glucocorticoid receptor gene in laboratory and wild rats: steroid binding properties of trinucleotide CAG repeat length variants. Heeley RP, etal., Mamm Genome 1998 Mar;9(3):198-203.
7. Institute for Animal Experimentation University of Tokushima School of Medicine Institute for Animal Experimentation University of Tokushima School of Medicine
8. Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment. Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
9. Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS. Lidman O, etal., J Neurosci 2003 Oct 29;23(30):9817-23.
10. Use of simple sequence length polymorphisms for genetic characterization of rat inbred strains. Otsen M, etal., Mamm Genome 1995 Sep;6(9):595-601.
11. RGD Strain RSO annotation pipeline RGD Automated Pipelines
12. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

Region

Strain QTL Data
Symbol Name Trait
Neudeg1 Neurodegradation QTL 1 nervous system integrity trait   (VT:0010566)    
Neudeg2 Neurodegradation QTL 2 nervous system integrity trait   (VT:0010566)    
Neuinf1 Neuroinflammation QTL 1 nervous system integrity trait   (VT:0010566)    
Neuinf2 Neuroinflammation QTL 2 nervous system integrity trait   (VT:0010566)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other These performed significantly greater amount of work in the aerobic endurance performance as compared to the COP strain (lowest performer). 1358977
strain_other On the basis of work, these females performed significantly better than the COP females. 1358977
strain_other These have shorter survival time after controlled hemorrhage than BN/HsdMcwiCrl but longer than DA/OlaHsd. 2302114
strain_phys_biochem exhibits the highest level of sensorimotor ability (motor coordination) among the eleven strains: ACI/SegHsd, AUG/OlaHsd, BUF/NHsd, COP/Hsd, DA/OlaHsd, F344/NHsd, PVG/OlaHsd, LEW, WKY, SR/Jr, and MNS 619608
strain_phys_biochem This strain was screened for genetic polymorphisms for 100 genomic loci in 55 genes ; Polymorphisms observed in this study can be found in NCBI dbSNP under accession numbers ss12588106 - ss12588203. This strain was used for genotyping candidate single nucleotide polymorphisms (reference Guryev et al., Single Nucleotide Polymorphisms associated with rat expressed sequences., submitted). SNPs obtained from this study can be found in NCBI dbSNP under accession numbers ss12535137 - ss12568440, ss12588074 - ss12588105 or Cuppen Group 737878

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-10-12 PVG/OlaHsd    PVG/OlaHsd    Name updated 68913 APPROVED
2015-10-12 PVG/OlaHsd    PVG/OlaHsd    Name updated 68913 APPROVED
2014-09-26 PVG/OlaHsd    PVG/OlaHsd    Name updated 68913 APPROVED
2014-09-26 PVG/OlaHsd    PVG/OlaHsd    Name updated 68913 APPROVED