RGD Reference Report - Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS. - Rat Genome Database

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Discrete gene loci regulate neurodegeneration, lymphocyte infiltration, and major histocompatibility complex class II expression in the CNS.

Authors: Lidman, O  Swanberg, M  Horvath, L  Broman, KW  Olsson, T  Piehl, F 
Citation: Lidman O, etal., J Neurosci 2003 Oct 29;23(30):9817-23.
RGD ID: 1358788
Pubmed: PMID:14586010   (View Abstract at PubMed)
PMCID: PMC6740878   (View Article at PubMed Central)

Neurodegeneration and inflammation are fundamental aspects of many neurological diseases. A genome-wide scan of the response to ventral root avulsion (VRA) in a rat F2 cross discloses specific gene regions that regulate these processes. Two gene loci displayed linkage to neurodegeneration and T cell infiltration, respectively, and a single locus displayed extreme linkage to VRA-induced major histocompatibility complex class II expression on microglia. The demonstration that polymorphic genes in different loci control neurodegeneration and CNS inflammation has implications for various experimental rodent nervous system paradigms and potentially for genetically regulated susceptibility to a variety of human CNS diseases.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Objects Annotated

QTLs
Neudeg1  (Neurodegradation QTL 1)
Neudeg2  (Neurodegradation QTL 2)
Neuinf1  (Neuroinflammation QTL 1)
Neuinf2  (Neuroinflammation QTL 2)
Neuinf3  (Neuroinflammation QTL 3)

Strains
DA/Ztm  (NA)
PVG.1AV1  (Piebald-Virol-Glaxo)
PVG/OlaHsd  (NA)


Additional Information