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Strain: WAG

Symbol: WAG
Strain: WAG
Full Name: Wistar Albino Glaxo
RGD ID: 61008
Citation ID: RRID:RGD_61008
Ontology ID: RS:0000967
Type: inbred
Source: Not Available
Origin: AL Bacharach, Glaxo Ltd 1924 from Wistar stock. Note that the presence of different coat color alleles in some sublines implies that this strain may have become genetically contaminated at some time in the past. It is therefore important that the subline should be stated carefully in published work. WAG/Cpb clearly differs from other sublines at many loci (Festing and Bender 1984).
Genetic Markers: a,c,h or H,depending onsubline;mostcommonlya,c,h.
Coat Color: Albino
Inbred Generations: 138
Last Known Status: Unknown

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Mammalian Phenotype

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References - curated
# Reference Title Reference Citation
1. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
2. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
3. The characteristics of motor activity in ISIAH rats in an open field test are controlled by genes on chromosomes 2 and 16. Redina OE, etal., Neurosci Behav Physiol. 2009 Jan;39(1):57-64. Epub 2008 Dec 17.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Strain QTL Data
Symbol Name Trait
Activ3 Activity QTL 3 locomotor behavior trait   (VT:0001392)    
Activ4 Activity QTL 4 locomotor behavior trait   (VT:0001392)    
Activ5 Activity QTL 5 locomotor behavior trait   (VT:0001392)    
Bp306 Blood pressure QTL 306 arterial blood pressure trait   (VT:2000000)    
Bp307 Blood pressure QTL 307 arterial blood pressure trait   (VT:2000000)    
Bw80 Body weight QTL 80 body mass   (VT:0001259)    
Kidm35 Kidney mass QTL 35 kidney mass   (VT:0002707)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_behavior Short latency to emerge from cage into familiar (4/12 males, 3/12 females) and novel environments (2/12 males, 3/12 females) (Harrington 1971a). High open-field ambulation (2/12)(Harrington 1972). High wheel activity (2/12) (Harrington 1971b). Low open-field defecation(7/8) but high ambulation and shock-avoidance learning (1/8) (Rick and Fulker 1972). 634612
strain_immunology Resistant to experimental allergic encephalomyelitis (Hughes and Stedronska 1973). Some sublines may carry recessive gene dx preventing anaphylactoid reaction to dextran (Harris et al1963). Susceptible to the induction of autoimmune thyroiditis (Rose 1975). Higher incidence of polyspermia than in PVG (Braden 1958). Susceible to iron deficiency. Low secondary antibody response to the polypeptide (T,G)-Pro-L (17/20) (Gnnther et al 1976). Poor (4/5) antibody response to a synthetic 20 amino acid peptide derived from the alpha helical region of the RT1-D-u beta chain (Murphy et al, 1994). 634612
strain_life_disease Endocardial disease 4% at an average age of 31 months (Boorman et al 1973). Tumours: medullary thyroid carcinoma 27%, chromophobe adenoma of the pituitary 68%, adrenal corticaladenoma 29%, pheochromocytoma 2%, islet cell adenoma 1%. Mean life-span more than 31months in females and 22 months in males (Boorman et al 1972). Mean life-span 31 months infemales with pituitary tumours found in 69% of females. Other common tumours include medullary thyroid carcinoma 40%, adrenal cortical adenoma 29%, fibroadenoma of breast 21% with 19 other types of tumour found in 290 animals (Boorman and Hollander 1973). 90% survival to 13months, 50% at 24 months and 10% at 31 months in virgin females, 90% at 23 months, 50% at29 months and 10% at 38 months in breeding females (Burek 1978). Pancreatic atrophy 16% infemales, 11% in males; hydronephrosis 16% in males; cystic ovaries 36% in males (Burek 1978). Bilateral retinal degeneration with early onset and slowly progressive course which resembles human retinitis pigmentosa (Lai et al 1980). Further details of aging given by Hollander (1976) 634612
strain_phys_biochem Low brain GABA (Rick et al 1971). Rij substrain develops spontaneously occurring spike-wave paroxysms on the electroencephalogram, accompanied by clinical phenomena resembling human petit mal or absence epilepsy. A second type of novel wave was not associated with any behavioural correlates and was seen exclusively during wakefulness (van Luijtelaar and Coenen1986, Coenen and van Luijtelaar 1987, Coenen et al 1992, van Luijtelaar and Coenen 1989). The condition appears to be due to more than one dominantly-acting genes (Peeters et al 1990,1992), and follows definite 24 hour rhythms (Van Luijrelaar and Coenen, 1988), being particularly marked during light slow wave sleep and passive wakefulness (Drinkenburg et al1991). The response to anti-epileptic drugs corresponds to that of human absence epilepsy (Peeters et al 1988). In contrast, the ACI strain was almost free of spike-wave discharges, while BN/Bi, B and G were intermediate (Inoue et al 1990). Some solvents for antiepileptic drugs have proepileptic potencies in this strain (Peeters et al, 1992). Blockage ofAMPA and kainate receptors led to an anti-epileptic effect without inducing behavioural alterations (Peeters et al,1994). A low dose of fentanyl (0.01mg/kg) with fluanisone (0.5 mg/kg) caused 634612
strain_reproduction Long gestation period (1/8) Peters (1986). 634612

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-02 WAG  Wistar Albino Glaxo  WAG    Name updated 68913 APPROVED