RGD Reference Report - The characteristics of motor activity in ISIAH rats in an open field test are controlled by genes on chromosomes 2 and 16. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

The characteristics of motor activity in ISIAH rats in an open field test are controlled by genes on chromosomes 2 and 16.

Authors: Redina, OE  Smolenskaya, SE  Maslova, LN  Sakharov, DG  Markel', AL 
Citation: Redina OE, etal., Neurosci Behav Physiol. 2009 Jan;39(1):57-64. Epub 2008 Dec 17.
RGD ID: 2306974
Pubmed: (View Article at PubMed) PMID:19089625
DOI: Full-text: DOI:10.1007/s11055-008-9100-8

Quantitative Trait Locus (QTL) analysis was used to identify the loci of polygenic characteristics in a study of the genetic determination of the behavior of rats with inherited stress-induced arterial hypertension (ISIAH rats). Analysis was performed using males of two populations of F2 hybrids (ISIAH x WAG) of different ages: 3-4 (n = 106) and six months (n = 130). Chromosomes 2 and 16 in the young population of F2 rats showed significant associations between two characteristics of behavior in ISIAH rats and genetic loci: a) the rats' motor activity at the periphery of the open field area with loci in the regions of markers D2Rat157-D2Rat88 (LOD score 4.83; p = 0.000058) and D16Rat32 (LOD score 3.71; p = 0.00023). Together, these two loci accounted for 42.9% of the trait variability; b) the rats' motor activity during the first minute of the open field test and loci in the region of the marker D16Rat58 (LOD score 3.78; p = 0.00028). Results obtained by QTL analysis demonstrated a relationship between the genetic control of these traits and the animals' age.

Annotation

Disease Annotations    

Phenotype Annotations    
Objects Annotated

QTLs
Activ3  (Activity QTL 3)
Activ4  (Activity QTL 4)
Activ5  (Activity QTL 5)

Strains
ISIAH  (Inherited stress-induced arterial hypertension)
WAG  (Wistar Albino Glaxo)


Additional Information