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Strain Registration

Strain: BB.SHR-(D4Mit6-Spr)/K

Symbol: BB.SHR-(D4Mit6-Spr)/K
Strain: BB.SHR-(D4Mit6-Spr)
Substrain: K
RGD ID: 1357346
Citation ID: RRID:RGD_1357346
Ontology ID: RS:0000371
Alleles: Npy
Also Known As: BB.SHR-(D4Mit6-Spr)/K; BB.LL
Type: congenic
Available Source: Not Available
Origination: Department of Laboratory Animal Science, Inst of Pathophysiology, University of Greifswald, Karlsburg, Germany
Description: BB/OK lymphopenic rats were crossed with non-lymphopenic, spontaneously hypertensive SHR/Mol rats. Rats heterzygous for D4Mit6, Npy, and Spr and homozygous for BB alleles were selected. After 5 backcross generations, rats were intercrossed. Rats homozygous at SHR loci of interest were selected.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84119,229,447 - 119,233,320RGD_MAPPER_PIPELINE
mRatBN7.2476,647,384 - 117,676,292RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0477,307,388 - 116,916,073RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04141,978,848 - 181,496,612RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4475,732,943 - 119,369,308RGD_MAPPER_PIPELINERGSC3.4





Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BB.SHR-(D4Mit6-Spr)/KRatincreased circulating cholesterol level  IAGP 619667compared to strain BB/OKRGD 
BB.SHR-(D4Mit6-Spr)/KRatincreased circulating triglyceride level  IAGP 619667compared to strain BB/OK RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BB.SHR-(D4Mit6-Spr)/KRatBB.SHR-(D4Mit6-Spr)/K  IEA 7241799 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
BB.SHR-(D4Mit6-Spr)/KRatbody mass  EXP 69707 RGD 

Related Phenotype Data for Term "BB.SHR-(D4Mit6-Spr)/K" (RS:0000371)

Rat Strains:
Clinical Measurements:
Experimental Conditions:
Measurement Methods:

#
Reference Title
Reference Citation
1. Phenotypic consequences after restoration of lymphopenia in the diabetes-prone BB/OK rat. Kloting I, etal., Biochem Biophys Res Commun 1997 Oct 9;239(1):106-10.
2. Congenic BB.SHR (D4Mit6-Npy-Spr) rats: a new aid to dissect the genetics of obesity. Kloting I, etal., Obes Res 2002 Oct;10(10):1074-7.
3. Quantitative trait loci on chromosomes 1 and 4 affect lipid phenotypes in the rat. Kovacs P and Kloting I, Arch Biochem Biophys 1998 Jun 1;354(1):139-43.
4. Mapping of quantitative trait loci for body weight on chromosomes 1 and 4 in the rat. Kovacs P and Kloting I, Biochem Mol Biol Int 1998 Feb;44(2):399-405.
5. Congenic BB.SHR rat provides evidence for effects of a chromosome 4 segment (D4Mit6-Npy approximately 1 cm) on total serum and lipoprotein lipid concentration and composition after feeding a high-fat, high-cholesterol diet. Kovacs P, etal., Metabolism 2001 Apr;50(4):458-62.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines



Flank 1 / 1 (D4Mit6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2476,647,384 - 76,647,568 (+)MAPPER
Rnor_6.0477,307,388 - 77,307,571NCBI
Rnor_5.04141,978,848 - 141,979,031UniSTS
RGSC_v3.4475,732,943 - 75,733,127RGD
RGSC_v3.4475,732,944 - 75,733,127UniSTS
Celera471,452,122 - 71,452,305UniSTS
Cytogenetic Map4q24UniSTS

Flank 2 / 1 (Spr)
Rat AssemblyChrPosition (strand)Source
GRCr84119,229,447 - 119,233,320 (-)NCBI
mRatBN7.24117,671,948 - 117,676,292 (-)NCBI
mRatBN7.2 Ensembl4117,671,949 - 117,675,678 (-)Ensembl
UTH_Rnor_SHR_Utx4123,153,277 - 123,157,012 (-)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.04118,928,408 - 118,932,143 (-)NCBI
UTH_Rnor_WKY_Bbb_1.04117,541,159 - 117,544,893 (-)NCBI
Rnor_6.04116,912,343 - 116,916,073 (-)NCBI
Rnor_6.0 Ensembl4116,912,351 - 116,916,236 (-)Ensembl
Rnor_5.04181,492,882 - 181,496,612 (-)NCBI
RGSC_v3.44119,365,578 - 119,369,308 (-)NCBI
RGSC_v3.14119,610,075 - 119,613,765 (-)NCBI
Celera4106,655,853 - 106,659,586 (-)NCBI
Cytogenetic Map4q34NCBI
1 to 1 of 1 rows
Symbol
Name
Trait
Bw40 Body weight QTL 40 body mass   (VT:0001259)    
1 to 1 of 1 rows