RGD Reference Report - Imbalances between tumor necrosis factor-alpha and its soluble receptor forms, and interleukin-1beta and interleukin-1 receptor antagonist in BAL fluid of cavitary pulmonary tuberculosis. - Rat Genome Database

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Imbalances between tumor necrosis factor-alpha and its soluble receptor forms, and interleukin-1beta and interleukin-1 receptor antagonist in BAL fluid of cavitary pulmonary tuberculosis.

Authors: Tsao, TC  Hong, J  Li, LF  Hsieh, MJ  Liao, SK  Chang, KS 
Citation: Tsao TC, etal., Chest. 2000 Jan;117(1):103-9.
RGD ID: 4143179
Pubmed: PMID:10631206   (View Abstract at PubMed)

OBJECTIVES: We investigated the possibility that the large pulmonary cavity in tuberculosis (TB) lesions might result from imbalances between tumor necrosis factor-alpha (TNF-alpha) and soluble TNF-alpha receptor forms (sTNF-RI and sTNF-RII), and interleukin-beta (IL-1beta) and IL-1 receptor antagonist (IL-1RA) in sites of local inflammation. PATIENTS AND METHODS: BAL was performed in 32 patients with active pulmonary TB, and the recovered BAL fluid (BALF) was examined for concentrations of TNF-alpha and its soluble receptor forms, IL-1beta, and IL-1RA. Patients were classified into two groups: group 1, patients with a large cavity (> or = 4 cm) on chest radiographs (n = 15); and group 2, patients with a small cavity (< 4 cm; n = 3) or no cavity (n = 14) on chest radiographs. RESULTS: The concentrations of TNF-alpha, IL-1beta, and IL-1RA in BALF were significantly higher in group 1 patients than in group 2 patients before standardization. The difference was also statistically significant for TNF-alpha and IL-1beta after standardization with urea. Furthermore, group 1 patients had significantly higher ratios of TNF-alpha to sTNF-RI and sTNF-RII and IL-1beta to IL-1RA compared with group 2 patients. CONCLUSIONS: These findings suggest that the relative abundance of TNF-alpha and IL-1beta associated with imbalances of secretion of soluble TNF-alpha receptor forms and IL-1RA may have caused tissue necrosis leading to cavity formation in patients with active pulmonary TB.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL1BHumanpulmonary tuberculosis severityIEP protein:increased expression:bronchioalveolar lavage fluid (human)RGD 
IL1RNHumanpulmonary tuberculosis severityIEP  RGD 
Il1bRatpulmonary tuberculosis severityISOIL1B (Homo sapiens)protein:increased expression:bronchioalveolar lavage fluid (human)RGD 
Il1bMousepulmonary tuberculosis severityISOIL1B (Homo sapiens)protein:increased expression:bronchioalveolar lavage fluid (human)RGD 
Il1rnRatpulmonary tuberculosis severityISOIL1RN (Homo sapiens) RGD 
Il1rnMousepulmonary tuberculosis severityISOIL1RN (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il1b  (interleukin 1 beta)
Il1rn  (interleukin 1 receptor antagonist)

Genes (Mus musculus)
Il1b  (interleukin 1 beta)
Il1rn  (interleukin 1 receptor antagonist)

Genes (Homo sapiens)
IL1B  (interleukin 1 beta)
IL1RN  (interleukin 1 receptor antagonist)


Additional Information