RGD Reference Report - Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans. - Rat Genome Database

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Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans.

Authors: Yu, Yi  Panhuysen, Carolien  Kranzler, Henry R  Hesselbrock, Victor  Rounsaville, Bruce  Weiss, Roger  Brady, Kathleen  Farrer, Lindsay A  Gelernter, Joel 
Citation: Yu Y, etal., Hum Mol Genet. 2006 Jul 15;15(14):2192-9. doi: 10.1093/hmg/ddl144. Epub 2006 Jun 1.
RGD ID: 401976474
Pubmed: PMID:16740595   (View Abstract at PubMed)
DOI: DOI:10.1093/hmg/ddl144   (Journal Full-text)

We report here a study considering association of alleles and haplotypes at the DOPA decarboxylase (DDC) locus with the DSM-IV diagnosis of nicotine dependence (ND) or a quantitative measure for ND using the Fagerstrom Test for Nicotine Dependence (FTND). We genotyped 18 single nucleotide polymorphisms (SNPs) spanning a region of approximately 210 kb that includes DDC and the genes immediately flanking DDC in 1,590 individuals from 621 families of African-American (AA) or European-American (EA) ancestry. Evidence of association (family-based tests) was observed with several SNPs for both traits (0.0002



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DDCHumannicotine dependence susceptibilityIAGP DNA:SNPs and haplotypes:introns:multiple (human)RGD 
DdcRatnicotine dependence susceptibilityISODDC (Homo sapiens)DNA:SNPs and haplotypes:introns:multiple (human)RGD 
DdcMousenicotine dependence susceptibilityISODDC (Homo sapiens)DNA:SNPs and haplotypes:introns:multiple (human)RGD 
FIGNL1Humannicotine dependence susceptibilityIAGP DNA:SNP and haplotype:: (rs10230343) (human)RGD 
Fignl1Ratnicotine dependence susceptibilityISOFIGNL1 (Homo sapiens)DNA:SNP and haplotype:: (rs10230343) (human)RGD 
Fignl1Mousenicotine dependence susceptibilityISOFIGNL1 (Homo sapiens)DNA:SNP and haplotype:: (rs10230343) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DDCHumanAddictive nicotine use susceptibilityIAGP DNA:SNPs and haplotypes:introns:multiple (human)RGD 
FIGNL1HumanAddictive nicotine use susceptibilityIAGP DNA:SNP and haplotype:: (rs10230343) (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ddc  (dopa decarboxylase)
Fignl1  (fidgetin-like 1)

Genes (Mus musculus)
Ddc  (dopa decarboxylase)
Fignl1  (fidgetin-like 1)

Genes (Homo sapiens)
DDC  (dopa decarboxylase)
FIGNL1  (fidgetin like 1)


Additional Information