RGD Reference Report - Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome.

Authors: Yamada, Y  Kato, K  Oguri, M  Yoshida, T  Yokoi, K  Watanabe, S  Metoki, N  Yoshida, H  Satoh, K  Ichihara, S  Aoyagi, Y  Yasunaga, A  Park, H  Tanaka, M  Nozawa, Y 
Citation: Yamada Y, etal., Int J Mol Med. 2008 Jun;21(6):801-8.
RGD ID: 2311309
Pubmed: PMID:18506375   (View Abstract at PubMed)

Metabolic syndrome is a risk factor for cardiovascular disease. The aim of the present study was to identify genetic variants that confer susceptibility to atherothrombotic cerebral infarction among individuals with metabolic syndrome in order to allow prediction of genetic risk for this condition. The study population comprised 1284 unrelated Japanese individuals with metabolic syndrome, including 313 subjects with atherothrombotic cerebral infarction and 971 controls. The genotypes for 296 polymorphisms of 202 candidate genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. The Chi-square test, multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of hypertension, hypercholesterolemia, and diabetes mellitus, as well as a stepwise forward selection procedure revealed that the 2445G-->A (Ala54Thr) polymorphism (rs1799883) of FABP2, the -108/3G-->4G polymorphism of IPF1 (S82168), the A-->G (Thr94Ala) polymorphism (rs2241883) of FABP1, the G-->A (Asp2213Asn) polymorphism (rs529038) of ROS1, the -11377C-->G polymorphism (rs266729) of ADIPOQ, the 162A-->C polymorphism (rs4769055) of ALOX5AP, the -786T-->C polymorphism (rs2070744) of NOS3, and the 3279C-->T polymorphism (rs7291467) of LGALS2 were associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction. Among these polymorphisms, the 2445G-->A (Ala54Thr) polymorphism of FABP2 was most significantly associated with this condition. Our results suggest that FABP2, IPF1, FABP1, ROS1, ADIPOQ, ALOX5AP, NOS3, and LGALS2 are susceptibility loci for atherothrombotic cerebral infarction among Japanese individuals with metabolic syndrome. Genotypes for these polymorphisms, especially for the 2445G-->A (Ala54Thr) polymorphism of FABP2, may prove informative for the prediction of genetic risk for atherothrombotic cerebral infarction among such individuals.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ALOX5APHumanbrain infarction  IAGP associated with Metabolic Syndrome X and DNA:polymorphism:g.162A>C rs4769055 (human)RGD 
Alox5apRatbrain infarction  ISOALOX5AP (Homo sapiens)associated with Metabolic Syndrome X and DNA:polymorphism:g.162A>C rs4769055 (human)RGD 
Alox5apMousebrain infarction  ISOALOX5AP (Homo sapiens)associated with Metabolic Syndrome X and DNA:polymorphism:g.162A>C rs4769055 (human)RGD 
PDX1Humancerebral infarction  IAGP associated with Metabolic Syndrome and DNA:duplication:5' utr:-108 3G>4G (human)RGD 
Pdx1Ratcerebral infarction  ISOPDX1 (Homo sapiens)associated with Metabolic Syndrome and DNA:duplication:5' utr:-108 3G>4G (human)RGD 
Pdx1Mousecerebral infarction  ISOPDX1 (Homo sapiens)associated with Metabolic Syndrome and DNA:duplication:5' utr:-108 3G>4G (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Alox5ap  (arachidonate 5-lipoxygenase activating protein)
Pdx1  (pancreatic and duodenal homeobox 1)

Genes (Mus musculus)
Alox5ap  (arachidonate 5-lipoxygenase activating protein)
Pdx1  (pancreatic and duodenal homeobox 1)

Genes (Homo sapiens)
ALOX5AP  (arachidonate 5-lipoxygenase activating protein)
PDX1  (pancreatic and duodenal homeobox 1)


Additional Information