RGD Reference Report - Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance. - Rat Genome Database

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Expression parameters of the inhibitors of apoptosis cIAP1 and cIAP2 in renal cell carcinomas and their prognostic relevance.

Authors: Kempkensteffen, C  Hinz, S  Christoph, F  Kollermann, J  Krause, H  Schrader, M  Schostak, M  Miller, K  Weikert, S 
Citation: Kempkensteffen C, etal., Int J Cancer. 2007 Mar 1;120(5):1081-6.
RGD ID: 1643526
Pubmed: PMID:17154176   (View Abstract at PubMed)
DOI: DOI:10.1002/ijc.22416   (Journal Full-text)

The expression of the inhibitor of apoptosis (IAP) family members cIAP1 and cIAP2 have been shown to be altered in various cancer entities. This study was done to characterize the tumor-related expression profile of cIAP1 and cIAP2 in patients with renal cell carcinomas (RCC) and to evaluate its potential predictive value after curative resection. Expression of cIAP1 and cIAP2 was analyzed by real-time RT-PCR in RCC and corresponding normal tissue samples obtained from a cohort of 127 RCC patients (median follow-up: 48 months) undergoing surgical treatment. Expression data was correlated to histopathological variables and outcome. Overexpression of cIAP1 and cIAP2 occurred in most RCC specimens (p < 0.001), but 20% of the patients had lower cIAP levels in malignant than in normal tissue. The cIAP1 expression correlated with the tumor stage, levels being higher in pT1 tumors than in advanced pathological stages (p = 0.002). Decreased cIAP1 expression in RCC relative to paired normal samples predicted an abbreviated time to recurrence (hazard rate 2.96; 95% CI: 1.23-7.09) and tumor-specific survival (hazard rate 2.78; 95% CI: 1.22-6.38) irrespective of the tumor stage and grade. The prognostic effect of cIAP1 was most pronounced in patients with pT3 disease (log rank test p = 0.001). The results of uni- and multivariate analysis suggest a prognostic value of cIAP1 expression for RCC patients, downregulation indicating an aggressive, potentially lethal phenotype.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
BIRC2Humanrenal cell carcinoma disease_progressionIEP mRNA:altered expression:kidneyRGD 
BIRC3Humanrenal cell carcinoma  IEP mRNA:altered expression:kidneyRGD 
Birc2Ratrenal cell carcinoma disease_progressionISOBIRC2 (Homo sapiens)mRNA:altered expression:kidneyRGD 
Birc2Mouserenal cell carcinoma disease_progressionISOBIRC2 (Homo sapiens)mRNA:altered expression:kidneyRGD 
Birc3Ratrenal cell carcinoma  ISOBIRC3 (Homo sapiens)mRNA:altered expression:kidneyRGD 
Birc3Mouserenal cell carcinoma  ISOBIRC3 (Homo sapiens)mRNA:altered expression:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Birc2  (baculoviral IAP repeat-containing 2)
Birc3  (baculoviral IAP repeat-containing 3)

Genes (Mus musculus)
Birc2  (baculoviral IAP repeat-containing 2)
Birc3  (baculoviral IAP repeat-containing 3)

Genes (Homo sapiens)
BIRC2  (baculoviral IAP repeat containing 2)
BIRC3  (baculoviral IAP repeat containing 3)


Additional Information