RGD Reference Report - The upregulated expression of sonic hedgehog in motor neurons after rat facial nerve axotomy. - Rat Genome Database

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The upregulated expression of sonic hedgehog in motor neurons after rat facial nerve axotomy.

Authors: Akazawa, C  Tsuzuki, H  Nakamura, Y  Sasaki, Y  Ohsaki, K  Nakamura, S  Arakawa, Y  Kohsaka, S 
Citation: Akazawa C, etal., J Neurosci. 2004 Sep 8;24(36):7923-30.
RGD ID: 1580344
Pubmed: PMID:15356205   (View Abstract at PubMed)
PMCID: PMC6729937   (View Article at PubMed Central)
DOI: DOI:10.1523/JNEUROSCI.1784-04.2004   (Journal Full-text)

Nerve injury leads to the induction of a large number of genes to repair the damage and to restore synaptic transmission. We have attempted to identify molecules whose mRNA expression is altered in response to facial nerve axotomy. Here we report that facial nerve axotomy upregulates Sonic hedgehog (Shh) and its receptor Smoothened (Smo) in facial motor neurons of adult rats, whereas facial nerve axotomy does not upregulate mRNA of Shh or Smo in neonatal rats. We tested whether overexpression of Shh in facial motor neurons of axotomized neonatal rats may promote neuronal survival. Adenovirus-mediated overexpression of Shh, but not that of beta-galactosidase, transiently rescues axotomy-induced neuronal cell death for 3-5 d after axotomy. Finally, the pharmacological inhibitor of Shh signaling, cyclopamine, induces motor neuron death in adult rats after axotomy. These results suggest that Shh plays a regulatory role in nerve injury.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
facial nerve development  IEP 1580344 RGD 
neuron projection regeneration  IEP 1580344 RGD 
response to axon injury  IMP 1580344 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuronal cell body  IDA 1580344 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Shh  (sonic hedgehog signaling molecule)
Smo  (smoothened, frizzled class receptor)


Additional Information