RGD Reference Report - Fine mapping reveals multiple loci and a possible epistatic interaction within the mammary carcinoma susceptibility quantitative trait locus, Mcs5. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Fine mapping reveals multiple loci and a possible epistatic interaction within the mammary carcinoma susceptibility quantitative trait locus, Mcs5.

Authors: Samuelson, DJ  Aperavich, BA  Haag, JD  Gould, MN 
Citation: Samuelson DJ, etal., Cancer Res. 2005 Nov 1;65(21):9637-42.
RGD ID: 1559294
Pubmed: PMID:16266982   (View Abstract at PubMed)
DOI: DOI:10.1158/0008-5472.CAN-05-1498   (Journal Full-text)

To identify high-frequency, low-penetrance breast cancer modifier genes, we have developed a rat genetic model that uses the Wistar-Kyoto (WKy) inbred strain, resistant to developing 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis, as a congenic donor and the susceptible Wistar-Furth (WF) strain as the recipient. Here, data from congenic rat lines containing smaller WKy genomic intervals of the Mcs5 quantitative trait locus region are presented to fine map three independently acting Mcs5 subloci. WKy-homozygous females from congenic lines defining Mcs5a, Mcs5b, and Mcs5c averaged, respectively, 4.0 +/- 0.4, 11.6 +/- 0.6, and 3.5 +/- 0.4 mammary carcinomas per rat. These phenotypic values are statistically different from the WF-homozygous phenotype value of 8.0 +/- 0.4, which is the baseline phenotype used for these experiments. We identified a likely Mcs5a x Mcs5b epistatic interaction that results in masking the increased susceptibility effect of the Mcs5b WKy allele by the Mcs5a WKy allele. We also provide evidence for a Mcs5a x Mcs5c interaction that is synergistic to decrease mammary carcinoma susceptibility below the additive effects of WKy alleles at each locus independently. The Mcs5 subloci are currently localized to 1.0, 7.5, and 4.5 Mb of rat chromosome 5, and the orthologous regions are on human chromosome 9 and mouse chromosome 4. These loci will provide unbiased candidate gene loci for evaluation in human case-control association studies.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Mcs13RatExperimental Mammary Neoplasms  IDA  RGD 
Mcs14RatExperimental Mammary Neoplasms  IDA  RGD 

Objects Annotated

QTLs
Mcs12  (Mammary carcinoma susceptibility QTL 12)
Mcs13  (Mammary carcinoma susceptibility QTL 13)
Mcs14  (Mammary carcinoma susceptibility QTL 14)

Objects referenced in this article
Marker D5Uwm63 D5Uwm63 Rattus norvegicus
Marker D5Uwm62 D5Uwm62 Rattus norvegicus
Marker D5Uwm65 D5Uwm65 Rattus norvegicus
Marker D5Uwm61 D5Uwm61 Rattus norvegicus
Marker D5Uwm68 D5Uwm68 Rattus norvegicus
Marker D5Uwm66 D5Uwm66 Rattus norvegicus
Marker D5Uwm64 D5Uwm64 Rattus norvegicus
Marker D5Uwm67 D5Uwm67 Rattus norvegicus
Marker D5Uwm60 D5Uwm60 Rattus norvegicus
Strain WF.WKY-(D5Uwm61-D5Uwm37)/Uwm null Rattus norvegicus
Strain WF.WKY-(D5Uwm63-D5Uwm60)/Uwm null Rattus norvegicus

Additional Information