RGD Reference Report - Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family.

Authors: Li, Y  Nowotny, P  Holmans, P  Smemo, S  Kauwe, JS  Hinrichs, AL  Tacey, K  Doil, L  Van Luchene, R  Garcia, V  Rowland, C  Schrodi, S  Leong, D  Gogic, G  Chan, J  Cravchik, A  Ross, D  Lau, K  Kwok, S  Chang, SY  Catanese, J  Sninsky, J  White, TJ  Hardy, J  Powell, J  Lovestone, S  Morris, JC  Thal, L  Owen, M  Williams, J  Goate, A  Grupe, A 
Citation: Li Y, etal., Proc Natl Acad Sci U S A 2004 Nov 2;101(44):15688-93. Epub 2004 Oct 26.
RGD ID: 1358618
Pubmed: PMID:15507493   (View Abstract at PubMed)
PMCID: PMC524264   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.0403535101   (Journal Full-text)

Although several genes have been implicated in the development of the early-onset autosomal dominant form of Alzheimer's disease (AD), the genetics of late-onset AD (LOAD) is complex. Loci on several chromosomes have been linked to the disease, but so far only the apolipoprotein E gene has been consistently shown to be a risk factor. We have performed a large-scale single-nucleotide polymorphism (SNP)-based association study, across the region of linkage on chromosome 12, in multiple case-control series totaling 1,089 LOAD patients and 1,196 control subjects and report association with SNPs in the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene. Subsequent analysis of GAPD paralogs on other chromosomes demonstrated association with two other paralogs. A significant association between LOAD and a compound genotype of the three GAPD genes was observed in all three sample sets. Individually, these SNPs make differential contributions to disease risk in each of the casecontrol series, suggesting that variants in functionally similar genes may account for series-to-series heterogeneity of disease risk. Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease onsetIAGP 1358618DNA:snps:5' utr more ...RGD 
Alzheimer's disease onsetIAGP 1358618DNA:snps:promoter more ...RGD 
Alzheimer's disease onsetISOGAPDH (Homo sapiens)1358618; 1358618DNA:snps:5' utr more ...RGD 
Alzheimer's disease onsetISOGAPDHS (Homo sapiens)1358618; 1358618DNA:snps:promoter more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gapdh  (glyceraldehyde-3-phosphate dehydrogenase)
Gapdhs  (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic)

Genes (Mus musculus)
Gapdh  (glyceraldehyde-3-phosphate dehydrogenase)
Gapdhs  (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic)

Genes (Homo sapiens)
GAPDH  (glyceraldehyde-3-phosphate dehydrogenase)
GAPDHS  (glyceraldehyde-3-phosphate dehydrogenase, spermatogenic)


Additional Information