RGD Reference Report - Exploring the role of short-course cyclosporin a therapy in preventing homograft valve calcification after transplantation. - Rat Genome Database

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Exploring the role of short-course cyclosporin a therapy in preventing homograft valve calcification after transplantation.

Authors: Chang, Q  Jing, H  Sun, M  Xu, P 
Citation: Chang Q, etal., Cell Immunol. 2014 Jan;287(1):36-45. doi: 10.1016/j.cellimm.2013.11.008. Epub 2013 Dec 8.
RGD ID: 11352276
Pubmed: PMID:24374105   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cellimm.2013.11.008   (Journal Full-text)

This study was designed to explore the role of short-course cyclosporin A therapy in preventing calcification. Homograft valves heterotopically allografted onto abdominal aorta from SD to Wistar rats. The expression of CD25, CD40L, CD71, calcium content and morphological change were observed. In control group, expression of immune indices got maximal at early stage postoperatively, and then gradually declined, remained at low level 12 weeks afterwards. In test group with Cyclosporin A, the expression of immune indices were lower than that of control group at 2-4 weeks postoperatively, but no significant difference was found 8 weeks afterwards. The calcification began from 4 weeks postoperatively, increased gradually and reached highest level at 12 weeks. In test group calcium content was much lower from 4 to 16 weeks postoperatively. It is concluded that cyclosporine A treatment can prevent calcification of homograft valves because it inhibited immune response at early stage after transplantation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Calcification of Aortic Valve treatmentISOCd40lg (Rattus norvegicus)11352276; 11352276 RGD 
Calcification of Aortic Valve treatmentIDA 11352276 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cd40lg  (CD40 ligand)

Genes (Mus musculus)
Cd40lg  (CD40 ligand)

Genes (Homo sapiens)
CD40LG  (CD40 ligand)


Additional Information