RGD Reference Report - Neuroprotective function of DJ-1 in Parkinson's disease. - Rat Genome Database

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Neuroprotective function of DJ-1 in Parkinson's disease.

Authors: Ariga, H  Takahashi-Niki, K  Kato, I  Maita, H  Niki, T  Iguchi-Ariga, SM 
Citation: Ariga H, etal., Oxid Med Cell Longev. 2013;2013:683920. doi: 10.1155/2013/683920. Epub 2013 May 16.
RGD ID: 10450523
Pubmed: PMID:23766857   (View Abstract at PubMed)
PMCID: PMC3671546   (View Article at PubMed Central)
DOI: DOI:10.1155/2013/683920   (Journal Full-text)

Parkinson's disease (PD) is caused by dopaminergic neuronal death in the substantia nigra, resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial dysfunction are thought to be major causes of neurodegeneration in PD. Although genetic and environmental factors are thought to affect the onset of PD, precise mechanisms at the molecular level have not been elucidated. The DJ-1 gene is a causative gene for familial PD (park7) and also an oncogene. DJ-1 has various functions, including transcriptional regulation, antioxidative stress reaction, and chaperone, protease, and mitochondrial regulation, and its activity is regulated by its oxidative status, especially that of cysteine 106 (C106) of DJ-1. Excess oxidation of DJ-1, which renders DJ-1 inactive, has been observed in patients with sporadic PD and Alzheimer's disease, suggesting that DJ-1 also participates in the onset and pathogenesis of sporadic PD as well as familial PD. DJ-1 is also a stress sensor and its expression is increased upon various stresses, including oxidative stress. In this review, we describe functions of DJ-1 against oxidative stress and possible roles of DJ-1 in the pathogenesis of PD.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PARK7HumanParkinson's disease  IAGP  RGD 
Park7RatParkinson's disease  ISOPARK7 (Homo sapiens) RGD 
Park7MouseParkinson's disease  ISOPARK7 (Homo sapiens) RGD 

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PARK7HumanParkinson's disease pathway   TAS  RGD 
Park7RatParkinson's disease pathway   ISOPARK7 (Homo sapiens) RGD 
Park7MouseParkinson's disease pathway   ISOPARK7 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Park7  (Parkinsonism associated deglycase)

Genes (Mus musculus)
Park7  (Parkinson disease (autosomal recessive, early onset) 7)

Genes (Homo sapiens)
PARK7  (Parkinsonism associated deglycase)


Additional Information